2025
A road map for uniform, comprehensive long-term follow-up after curative therapy for sickle cell disease
Shenoy S, Kanter J, Kassim A, Fitzhugh C, Stenger E, Bhatia M, Pecker L, Krishnamurti L, King A. A road map for uniform, comprehensive long-term follow-up after curative therapy for sickle cell disease. Blood Advances 2025, 9: 3090-3103. PMID: 39993235, DOI: 10.1182/bloodadvances.2024013953.Peer-Reviewed Original Research
2024
Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease
Zhang Y, Jia C, Guo M, Chen Q, Wen Y, Wang T, Xie Y, Fan X, Gao J, Yarovinsky T, Liu R, Jiang Z, Wang M, Zhou J, Che D, Fu L, Edelson R, Gu X, Hwa J, Tang W. Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease. Advanced Science 2024, 12: 2406282. PMID: 39665236, PMCID: PMC11792051, DOI: 10.1002/advs.202406282.Peer-Reviewed Original ResearchKawasaki diseaseCD14<sup>+</sup>CD16<sup>+</sup> monocytesPlatelet-monocyte aggregatesAberrant immune responseAcute febrile illnessCoronary artery aneurysmsNuclear factor-kappaBSystemic vasculitisPlatelet-monocyteProinflammatory monocytesPlatelet hyperreactivityArtery aneurysmVasculopathyFebrile illnessCytokine mediatorsHyperactive plateletsReduce inflammationPlatelet glycoproteinImmune responseInterleukin-1Platelet activationPositive feedback loopLigand 1MonocytesGrowth factor
2023
EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCells
2022
Contrasting Cases of HIV Vasculopathy Associated Fusiform Aneurysms
Kyle K, Maher M, Achhra A, Venna N. Contrasting Cases of HIV Vasculopathy Associated Fusiform Aneurysms. The Neurohospitalist 2022, 13: 69-73. PMID: 36531848, PMCID: PMC9755620, DOI: 10.1177/19418744221122863.Peer-Reviewed Original ResearchHuman immunodeficiency virusProgressive multifocal leukoencephalopathyFusiform aneurysmsAntiretroviral therapy adherenceAcquired Immunodeficiency SyndromeSpectrum of severityDevelopment of aneurysmsCerebral toxoplasmosisMultifocal leukoencephalopathyClinical courseImmunodeficiency syndromeImmunodeficiency virusTherapy adherenceVessel occlusionAneurysm formationAneurysm thrombosisIntracranial fusiform aneurysmsAneurysmsCerebral aneurysmsNine monthsFirst caseCase twoVasculopathyMoyamoyaLeukoencephalopathy
2021
Chronic Thromboembolic Pulmonary Hypertension: the Bench
Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.Peer-Reviewed Original ResearchConceptsPulmonary embolismAcute pulmonary embolismThromboembolic pulmonary hypertensionPlatelet-rich thrombiPulmonary hypertensionUncommon complicationMedical therapyPulmonary vasculatureImmune cellsAnimal modelsEndothelial cellsPathobiologyPlatelet biologyThrombusHuman samplesTherapyCurrent knowledgeSummaryThe developmentCTEPHHypertensionVasculopathyCellsComplicationsEmbolismInflammationCardiac allograft vasculopathy: current review and future research directions
Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovascular Research 2021, 117: 2624-2638. PMID: 34343276, PMCID: PMC8783389, DOI: 10.1093/cvr/cvab259.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathyAllograft vasculopathyImmune-mediated vasculopathyLate graft lossGraft lossCardiac transplantationOrgan graftsTransplanted heartsCurrent therapiesVascular remodellingVasculopathyMajor causeCurrent reviewRemodellingTransplantationPathogenesisGraftTherapyPerfusionIncidenceDiagnosisVasculature
2019
The color of skin: purple diseases of the skin, nails, and mucosa
Steuer AB, Cohen JM. The color of skin: purple diseases of the skin, nails, and mucosa. Clinics In Dermatology 2019, 37: 528-547. PMID: 31896408, DOI: 10.1016/j.clindermatol.2019.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAntiphospholipid SyndromeCalciphylaxisChurg-Strauss SyndromeColorCryoglobulinemiaDiagnosis, DifferentialGranulomatosis with PolyangiitisHumansLevamisoleMicroscopic PolyangiitisNecrosisPolyarteritis NodosaPurpura FulminansPurpura, Thrombotic ThrombocytopenicSkinVasculitisWarfarinConceptsCutaneous vasculitisCutaneous small vessel vasculitisLevamisole-induced vasculopathyAntiphospholipid antibody syndromeSmall vessel vasculitisThrombotic thrombocytopenic purpuraAntibody syndromeEosinophilic granulomatosisPolyarteritis nodosumEcthyma gangrenosumMicroscopic polyangiitisSkin necrosisInfectious dermatosesLichen planusPurpura fulminansThrombocytopenic purpuraInflammatory dermatosesSystemic diseaseClinical appearanceKaposi's sarcomaVasculitisPolyangiitisGranulomatosisVasculopathyDermatosesAdverse Radiation Effects
Cheok SK, Chiang VL. Adverse Radiation Effects. Progress In Neurological Surgery 2019, 34: 138-148. PMID: 31096237, DOI: 10.1159/000493058.Peer-Reviewed Original ResearchZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
Jane-Wit D, Fang C, Liu L, Qin L, Li G, Tellides G, Pober J. ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy. The Journal Of Heart And Lung Transplantation 2019, 38: s249. DOI: 10.1016/j.healun.2019.01.618.Peer-Reviewed Original ResearchCardiac allograft vasculopathyAllograft vasculopathyHumanized mouse modelMembrane attack complexNF-κB-inducing kinaseTransplant biopsiesMouse modelEC activationHuman coronary artery segmentsEndothelial cellsAntibody-mediated rejectionTransplant organ rejectionCoronary artery segmentsHuman lymphoid cellsVascular inflammationOrgan rejectionArtery segmentsPharmacologic alterationsVasculopathyLymphoid cellsNF-kBClinical relevance
2017
Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies
Mossa-Basha M, Shibata DK, Hallam DK, de Havenon A, Hippe DS, Becker KJ, Tirschwell DL, Hatsukami T, Balu N, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies. Stroke 2017, 48: 3026-3033. PMID: 29030476, PMCID: PMC5687293, DOI: 10.1161/strokeaha.117.018227.Peer-Reviewed Original ResearchConceptsIntracranial vessel wall magnetic resonance imagingVessel wall magnetic resonance imagingLuminal imagingIntracranial vasculopathyMagnetic resonance imagingInflammatory vasculopathyWall involvementResonance imagingReversible cerebral vasoconstriction syndromeCerebral vasoconstriction syndromeIntracranial atherosclerotic diseasePattern of involvementAtherosclerotic diseaseLesion eccentricityPostcontrast enhancementClinical dataSyndrome patientsVasculopathyPatient basisPatient analysisDiagnostic agreementSlight agreementDiagnosisDiagnostic confidenceLesions
2016
Cutaneous Vasculopathy as an Adverse Effect of the Anti–Vascular Endothelial Growth Factor Agent Axitinib
Shi VJ, Galan A, Odell ID, Choi JN. Cutaneous Vasculopathy as an Adverse Effect of the Anti–Vascular Endothelial Growth Factor Agent Axitinib. JAMA Dermatology 2016, 152: 222. PMID: 26509864, DOI: 10.1001/jamadermatol.2015.3209.Peer-Reviewed Original Research
2015
Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes
Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes. Stroke 2015, 46: 1567-1573. PMID: 25953365, DOI: 10.1161/strokeaha.115.009037.Peer-Reviewed Original ResearchConceptsReversible cerebral vasoconstriction syndromeVessel wall magnetic resonance imagingCerebral vasoconstriction syndromeMagnetic resonance imagingT2 hyperintensityIntracranial vasculopathyResonance imagingWall thickeningPattern of enhancementCases of atherosclerosisIntracranial vascular diseaseT2 signal characteristicsExcellent inter-reader agreementInter-reader agreementVasculitic lesionsInvasive workupWall involvementStenotic lesionsVasculopathic processPostcontrast enhancementVascular diseaseDifferential diagnosisVasculopathyLesion typeSyndrome
2014
(875) Localization of microRNAs in Cardiac Allograft Vasculopathy With In Situ Hybridization; a Role in Immune Regulation and/or Fibrosis?
Huibers M, van Holthe tot Echten B, Peeters T, de Jonge N, Tellides G, de Weger R. (875) Localization of microRNAs in Cardiac Allograft Vasculopathy With In Situ Hybridization; a Role in Immune Regulation and/or Fibrosis? The Journal Of Heart And Lung Transplantation 2014, 33: s315. DOI: 10.1016/j.healun.2014.01.852.Peer-Reviewed Original Research
2013
IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHY
Jane–Wit D, Pober J, Tellides G. IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHY. Journal Of The American College Of Cardiology 2013, 61: e2109. DOI: 10.1016/s0735-1097(13)62109-9.Peer-Reviewed Original Research
2007
Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients?
Al Chekakie M, Thompson D, Wang F, Ganguly J, Chawla R, Akar J, Barron J. Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients? Journal Of Cardiac Failure 2007, 13: s117-s118. DOI: 10.1016/j.cardfail.2007.06.459.Peer-Reviewed Original ResearchActivated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling
Sadeghi MM, Bender JR. Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling. Trends In Cardiovascular Medicine 2007, 17: 5-10. PMID: 17210471, DOI: 10.1016/j.tcm.2006.07.003.Peer-Reviewed Original ResearchObliterative vasculopathy in systemic sclerosis: endothelial precursor cells as novel targets for therapy
Hinchcliff M, Varga J. Obliterative vasculopathy in systemic sclerosis: endothelial precursor cells as novel targets for therapy. Expert Review Of Clinical Immunology 2007, 3: 11-15. PMID: 20476946, DOI: 10.1586/1744666x.3.1.11.Peer-Reviewed Original ResearchSystemic sclerosisObliterative vasculopathyOpen-label clinical trialEfficacy of statinsChronic cardiovascular diseasePrecursor cellsSerious clinical manifestationsEndothelial precursor cellsChronic vasculopathyVascular obliterationClinical manifestationsVascular damageVascular precursor cellsClinical trialsTherapeutic roleCardiovascular diseaseEffective treatmentImpaired productionVasculopathySclerosisNovel targetStatinsDefective vasculogenesisAtorvastatinEndothelial precursors
2001
Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediated via Reductions of VEGF-A Expression and VEGF Receptor Activation
Pinter E, Haigh J, Nagy A, Madri J. Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediated via Reductions of VEGF-A Expression and VEGF Receptor Activation. American Journal Of Pathology 2001, 158: 1199-1206. PMID: 11290536, PMCID: PMC1891927, DOI: 10.1016/s0002-9440(10)64069-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsEndothelial Growth FactorsFetal DiseasesFetusHyperglycemiaLymphokinesMicePhosphorylationReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorTime FactorsVascular DiseasesVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVEGF receptorsMajor congenital malformationsCongenital cardiovascular abnormalitiesVEGF/VEGF receptorVitelline circulationNovel therapeutic approachesLevels of VEGFReduction of VEGFCause of mortalityDiabetic mothersInsult resultsVEGF levelsCardiovascular abnormalitiesHyperglycemic insultGlucose levelsTherapeutic approachesCongenital malformationsResultant abnormalitiesReceptor activationVEGF receptor activationCardiovascular systemTeratogenic agentsVasculopathyDiabetesConceptus
2000
Advanced Glycosylation Endproducts and Diabetic Vascular Disease
Bucala R. Advanced Glycosylation Endproducts and Diabetic Vascular Disease. Developments In Cardiovascular Medicine 2000, 224: 287-303. DOI: 10.1007/978-1-4615-4649-8_15.Peer-Reviewed Original ResearchDiabetic vascular diseaseVascular diseaseAtherosclerotic vascular diseaseClinical pharmacological studiesProgressive vasculopathyOverall morbidityMicrovascular diseaseAnatomic typesPersistent hyperglycemiaDiabetic complicationsEtiologic roleAdvanced glycosylation endproductsBiochemical abnormalitiesDiabetic sequelaeNon-enzymatic glycosylationPharmacological studiesUnderlying causeDiseaseCapillary bedComplicationsBasic laboratoryVasculopathyMorbidityHyperglycemiaRetinopathy
1998
Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit
Panagiotopoulos S, O'Brien R, Bucala R, Cooper M, Jerums G. Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit. Atherosclerosis 1998, 136: 125-131. PMID: 9544739, DOI: 10.1016/s0021-9150(97)00192-5.Peer-Reviewed Original ResearchConceptsAdvanced glycosylation endproductsAortic archAbdominal aortaAdvanced glycationPlaque formationVasculopathy of diabetesAnti-atherogenic effectsHigh-cholesterol dietCholesterol-fed rabbitsDevelopment of atherosclerosisDegree of atheromaCholesterol dietAortaAtheromaRabbitsThoracicAminoguanidineDosesGlycationTreatmentArchAge levelsNon-enzymatic interactionVasculopathySudan IV
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply