2025
2002-LB: Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist—Results of a Phase 1b/2a Clinical Trial
DAHL K, ADELBORG K, DEY S, DUQUE DO VALE R, KEY C, TOUBRO S, JASTREBOFF A. 2002-LB: Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist—Results of a Phase 1b/2a Clinical Trial. Diabetes 2025, 74 DOI: 10.2337/db25-2002-lb.Peer-Reviewed Original ResearchMultiple-ascending doseOnce-weeklyConsistent with dose proportionalityGLP-1Double-blind studyBody weightBody weight reductionDose escalationIncreasing dose levelsDose proportionalityMaintenance doseTolerability profileBaseline BMISingle-centerHbA1c <Treatment armsPart BAgonist resultsDose levelsTreatment durationAmylin agonistsB-E.Percentage changePlaceboTEAEsA Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for Appendiceal and Colorectal Adenocarcinoma with Peritoneal Metastasis
Bader J, Ospina A, Liu S, Reddy B, Gupta P, Tomlin R, Cecchini M, Sundar R, Turaga K. A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for Appendiceal and Colorectal Adenocarcinoma with Peritoneal Metastasis. Annals Of Surgical Oncology 2025, 1-11. PMID: 40445508, DOI: 10.1245/s10434-025-17517-0.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyPeritoneal surface malignanciesStandard of careHIPEC regimensColorectal cancerAppendiceal cancerCytoreductive surgeryIntraperitoneal chemotherapyPeritoneal metastasisTumor susceptibilityClinical trialsStandard of care regimenOpen-label clinical trialColorectal peritoneal metastasesHigh-grade appendicealRegimens to patientsPatient standard of careChemotherapy combinationsDiagnostic laparoscopySurface malignanciesSingle-centerChemotherapy sensitivityBiopsy tissueBackgroundCurrent treatmentsColorectal adenocarcinomaRisk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures
Punia V, Byrnes M, Thompson N, Ayub N, Rubinos C, Zafar S, Sivaraju A, investigators F. Risk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures. Epilepsia 2025 PMID: 40387211, DOI: 10.1111/epi.18464.Peer-Reviewed Original ResearchAcute symptomatic seizuresAntiseizure medicationsUnprovoked seizuresRisk of unprovoked seizuresSymptomatic seizuresAssociated with electrographic seizuresMedian Follow-UpRetrospective cohort studyCox proportional hazards modelsCause-specific Cox proportional hazards modelsProportional hazards modelIncidence of unprovoked seizuresASyS patientsConsecutive adultsSingle-centerElectrographic seizuresNo significant differenceCumulative incidenceFollow-upCohort studyPatient populationFunctional outcomesSeizure riskPatientsHospital dischargeThe United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort
Leonard D, Natalwala I, Taplin S, Burdon J, Clarke E, Seitz A, Merchant W, Wilks D, Clark B, Bellew M, Baker R, Bourke G, Kay S. The United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 106: 331-341. PMID: 40472654, DOI: 10.1016/j.bjps.2025.05.001.Peer-Reviewed Original ResearchConceptsDonor-specific antibodiesFollow-upSingle-centerYears of follow-upSemmes-Weinstein monofilament testBox & Block TestHistory of dialysisLevel of amputationComposite functional scoresPatient satisfaction questionnaireWorld's first caseFunctional outcome measuresUpper limb transplantationMycophenolate mofetilRenal impairmentClinically significant improvementPsychological follow-upImmunosuppression monitoringGraft survivalRejection monitoringSecondary surgeryImmunological evaluationSurgical techniqueMonofilament testSF-36Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care
Punia V, Byrnes M, Thompson N, Ayub N, Rubinos C, Zafar S, Sivaraju A, Ying Z, Fesler J, Hantus S, investigators P. Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care. Annals Of Clinical And Translational Neurology 2025, 12: 1225-1239. PMID: 40244869, PMCID: PMC12172096, DOI: 10.1002/acn3.70039.Peer-Reviewed Original ResearchConceptsAcute symptomatic seizuresSymptomatic seizuresUnprovoked seizuresASyS patientsEpileptiform abnormalitiesMedian 14-month follow-upContinuous EEGRetrospective study of adultsCox proportional hazards modelsCause-specific Cox proportional hazards modelsProportional hazards modelRisk of unprovoked seizuresOutpatient EEGAlive patientsStudy of adultsOutpatient careSingle-centerRetrospective studyFollow-upPatientsCumulative incidence functionHazards modelSeizuresPost-discharge managementAbnormalitiesUnderstanding Surgical Management and Outcomes in Mitral Valve Endocarditis
Dzilic E, Niedermayer S, Burri M, Amabile A, Krane M, Vitanova K. Understanding Surgical Management and Outcomes in Mitral Valve Endocarditis. Journal Of Clinical Medicine 2025, 14: 2712. PMID: 40283542, PMCID: PMC12027858, DOI: 10.3390/jcm14082712.Peer-Reviewed Original ResearchMitral valve endocarditisMitral valve repairValve endocarditisValve repairPropensity score matchingValve replacementScore matchingNative mitral valve endocarditisMitral valve replacementRetrospective cohort studyLong-term survivalConsecutive patientsSurgical outcomesValve reconstructionAbscess formationSingle-centerSurgical managementEndocarditisSurgical patientsFollow-upCohort studyPatientsTreatment assignment biasMortality rateSurvival
2024
Immersive Virtual Reality Versus Mannequin-based Simulation Training for Trauma Resuscitation: A Randomized Controlled Noninferiority Trial
Lange M, Bērziņš A, Whitfill T, Kravčuks J, Skotele D, Lice E, Stepens A. Immersive Virtual Reality Versus Mannequin-based Simulation Training for Trauma Resuscitation: A Randomized Controlled Noninferiority Trial. Military Medicine 2024, 190: e1216-e1223. PMID: 39673391, DOI: 10.1093/milmed/usae510.Peer-Reviewed Original ResearchMannequin-based simulationTrauma resuscitation trainingRandomized controlled noninferiority trialSystem Usability ScaleTrauma simulationsResuscitation trainingIntervention groupMannequin-based simulation trainingNoninferiority trialSimulator Sickness QuestionnaireControl groupVirtual reality simulatorControlled noninferiority trialMinimal adverse effectsTrauma resuscitation skillsTotal severity scoreResuscitation skillsSingle-centerPrimary outcomeSeverity scoreSecondary outcomesTrauma resuscitationTrauma ScoreImmersive virtual reality simulationSimulation trainingRelationship Between Gender Identity and Underrepresented-In-Medicine Identity on Emergency Medicine Resident Feedback
Coughlin R, Bod J, Bonner S, Gore K, Tsyrulnik A, Devlin D, Srica N, Della-Giustina D, Phadke M, Dziura J, Goldflam K, Gottlieb M. Relationship Between Gender Identity and Underrepresented-In-Medicine Identity on Emergency Medicine Resident Feedback. Journal Of Emergency Medicine 2024, 72: 97-103. PMID: 40288940, DOI: 10.1016/j.jemermed.2024.11.019.Peer-Reviewed Original ResearchAnalyzing determinants of premature trial discontinuation in leukemia clinical trials
Rotter L, Alhajahjeh A, Stempel J, Grimshaw A, Bewersdorf J, Blaha O, Kewan T, Podoltsev N, Shallis R, Mendez L, Stahl M, Zeidan A. Analyzing determinants of premature trial discontinuation in leukemia clinical trials. Leukemia & Lymphoma 2024, 66: 289-297. PMID: 39440622, DOI: 10.1080/10428194.2024.2416565.Peer-Reviewed Original ResearchClinical trialsSlow accrualLeukemia trialsEarly-phase trialsNon-randomized trialsAcademic-sponsored trialsImprove patient outcomesLeukemia clinical trialsSingle-centerTrial discontinuationSponsored trialsSmall trialsLeukemiaEarly terminationPatient outcomesLate-phaseIndependent reviewersTermination ratesComprehensive searchTrialsSingle‑center, retrospective, evaluator‑blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2‑miR‑H9/hsa‑miR‑3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone
Kim W, Kim K, Kang H, Byun Y, Piao X, Kim Y, Lee S, Yun S, Ha Y, Kim J, Kim I. Single‑center, retrospective, evaluator‑blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2‑miR‑H9/hsa‑miR‑3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone. Oncology Letters 2024, 29: 23. PMID: 39512501, PMCID: PMC11542165, DOI: 10.3892/ol.2024.14770.Peer-Reviewed Original Research12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study
Saini J, Singh S, Ebbehøj A, Zhang C, Nathani R, Fell V, Atkinson E, Achenbach S, Rivard A, Singh R, Grebe S, Bancos I. 12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study. Journal Of The Endocrine Society 2024, 8: bvae163.295. PMCID: PMC11454430, DOI: 10.1210/jendso/bvae163.295.Peer-Reviewed Original ResearchUrine steroid metabolomeAutonomous cortisol secretionSteroid metabolomeReference subjectsCortisol secretionMild autonomous cortisol secretionSteroid profileSteroid productionSingle-center cross-sectional studyCompared to reference subjectsUrine steroid profileSubgroup of patientsArea under the curveHigh-resolution mass spectrometry assayCross-sectional studyCircadian cortisol secretionMass spectrometry assaySingle-centerAndrogen ratioFree cortisolCircadian secretionPatientsMetabolomicsSteroidsSeparate daysTeleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial
Gentle S, Trulove S, Rockwell N, Rutledge C, Gaither S, Norwood C, Wallace E, Carlo W, Tofil N. Teleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial. Pediatric Research 2024, 97: 222-228. PMID: 39341942, PMCID: PMC11798843, DOI: 10.1038/s41390-024-03545-1.Peer-Reviewed Original ResearchNeonatal resuscitationBag-mask ventilationQuality of resuscitationRoutine resuscitationNo-flow fractionResuscitation groupDelivery outcomesChest compressionsAdverse delivery outcomesQuality of neonatal resuscitationHigh-risk deliveriesAssociated with survivalHospital settingQuality of chest compressionsTime to intubationPreterm infantsNewborn resuscitationSingle-centerEpinephrine administrationLow failure rateResultsFifty-onePrimary outcomeSecondary outcomesResuscitationSimulated resuscitationPatients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy
Akiyama S, St-Pierre J, Traboulsi C, Silfen A, Rai V, Rodriguez T, Erondu A, Steinberg J, Shaffer S, Christensen B, Rubin D. Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy. Npj Gut And Liver 2024, 1: 5. DOI: 10.1038/s44355-024-00005-9.Peer-Reviewed Original ResearchHistologic normalizationUlcerative colitisDe-EscalationUC patientsDe-escalation of therapyTherapeutic de-escalationMedian Follow-UpDe-escalation groupProportion of patientsStudy assessed outcomesHistological recurrenceRecurrence rateSingle-centerClinical stabilityTherapeutic changeRemission outcomesFollow-upTherapyPatientsImmunomodulationAminosalicylatesWithdrawalColitisMonthsOutcomesMechanical versus biological mitral valve replacement: Insights from propensity score matching on survival and reoperation rates
Feirer N, Buchner A, Weber M, Lang M, Dzilic E, Amabile A, Geirsson A, Trenkwalder T, Krane M, Vitanova K. Mechanical versus biological mitral valve replacement: Insights from propensity score matching on survival and reoperation rates. Journal Of Thoracic And Cardiovascular Surgery 2024, 169: 1717-1727. PMID: 39067811, DOI: 10.1016/j.jtcvs.2024.07.038.Peer-Reviewed Original ResearchMitral valve replacementBiological mitral valve replacementPropensity-score matchingValve replacementReoperation rateCumulative incidenceFollow-upMechanical mitral valve replacementMedian follow-up timeCumulative incidence of reoperationSurgical mitral valve replacementSymptomatic mitral valve diseaseIncidence of reoperationThirty-day mortalityHigh-volume centersMitral valve diseaseHistory of neurological disordersPropensity score matchingAnalyzed time pointsConcomitant proceduresPeriprocedural complicationsSingle-centerThirty-dayRetrospective studyReoperation
2023
Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review
Dodamani M, Memon S, Karlekar M, Lila A, Khan M, Sarathi V, Arya S, Jamale T, Thakare S, Patil V, Shah N, Bergwitz C, Bandgar T. Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review. Calcified Tissue International 2023, 114: 137-146. PMID: 37981601, DOI: 10.1007/s00223-023-01156-2.Peer-Reviewed Original ResearchConceptsSingle-center experienceHereditary hypophosphatemic ricketsRenal calcificationSLC34A3 mutationsSystematic reviewHypophosphatemic ricketsLow bone mineral densityC-terminal FGF23Median age 38 yearsBone mineral densityIron deficiency anemiaPhenotype-genotype correlationAge 38 yearsDisorders of phosphate homeostasisRickets/osteomalaciaNon-truncating variantsLow BMDNormal BMDBone involvementDeficiency anemiaSingle-centerMineral densityCase seriesElevated FGF23Initial misdiagnosisClinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience
Jeong J, Oh K, Sohn J, Jun D, Shin J, Lee K, Lee J. Clinical Course and Mutational Analysis of Patients with Cystine Stone: A Single-Center Experience. Biomedicines 2023, 11: 2747. PMID: 37893120, PMCID: PMC10604214, DOI: 10.3390/biomedicines11102747.Peer-Reviewed Original ResearchClinical courseCystine stonesMutation analysis of patientsSingle-center experienceAnalysis of patientsTertiary medical centerClinical presentationRecurrent stonesSingle-centerLaboratory findingsKorean patientsPatient phenotypesPatientsGenetic disordersKorean cohortCystinuriaMedical CenterGenetic analysisMutation analysisSurgeryB mutationsType A.Type B mutationsPhenotypeGenotypesIoxaglate Versus IoDixanol for the Prevention of Contrast-Induced Nephropathy: The IDPC Trial.
Freitas R, Tanajura L, Mehran R, Chamié D, Chaves A, Centemero M, Braga S, Costa R, Cao D, Sousa A, Feres F, Costa J. Ioxaglate Versus IoDixanol for the Prevention of Contrast-Induced Nephropathy: The IDPC Trial. Journal Of Invasive Cardiology 2023, 35: e281-e290. PMID: 37220640, DOI: 10.25270/jic/21.00249.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyNon-dialytic chronic kidney diseaseAcute coronary syndromePrevention of contrast-induced nephropathyChronic kidney diseaseHigh riskMean volume of contrast mediumDiabetes mellitusOccurrence of contrast-induced nephropathyKidney diseaseIso-osmolar contrastVolume of contrast mediumAcute coronary syndrome patientsIncreased risk of dialysisHigh-risk patientsRisk of dialysisAdverse cardiac eventsChronic heart failureContrast media administrationCoronary artery diseaseTreatment of coronary artery diseaseConsecutive patientsPrimary endpointNo significant differenceSingle-centerBleeding and ketorolac use in pediatric circumcision
Lee J, Zhou E, Davis R, Ouyang Y, Lin H, Yudkowitz F. Bleeding and ketorolac use in pediatric circumcision. Pediatric Anesthesia 2023, 33: 481-485. PMID: 36892424, DOI: 10.1111/pan.14661.Peer-Reviewed Original ResearchConceptsClinically significant bleedingPostoperative bleedingKetorolac groupSignificant bleedingRisk of clinically significant bleedingReturn to the operating roomNon-ketorolac groupPediatric male patientsPediatric patients 1Postoperative pain controlRetrospective cohort studyPlacement of suturesStatistically significant differenceIntraoperative ketorolacKetorolac useMultimodal regimenKetorolac administrationPatient 1Pain controlSingle-centerMale patientsPediatric circumcisionKetorolacSurgical proceduresBleedingElectric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial
Jimenez J, Munroe E, Weirauch A, Fiorino K, Culter C, Nelson K, Labaki W, Choi P, Co I, Standiford T, Prescott H, Hyzy R. Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial. Critical Care 2023, 27: 21. PMID: 36650593, PMCID: PMC9843117, DOI: 10.1186/s13054-023-04315-x.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureAcute respiratory distress syndromeRespiratory distress syndromeDistress syndromeRandomized crossover pilot trialCrossover pilot trialModerate-severe acute respiratory distress syndromePEEP titrationStatic respiratory system complianceMethodsA single-centerPositive end-expiratory pressure titrationRespiratory system compliancePilot trialPositive end-expiratory pressure selectionEnd-expiratory pressureConclusionsIn patientsEIT-guided PEEP titrationPaO2/FiO2 ratioBackgroundIn patientsSingle-centerMechanical ventilationStatistically significant changesPrimary outcomeSecondary outcomesDriving pressure
2021
Étude D-CBP : Évaluation des délais de prise en charge du cancer broncho- pulmonaire au sein du service de Pneumologie et d’Oncologie Thoracique du CHU de Caen
Deshayes S, Ferreira D, Madelaine J, Oulkhouir Y, Campbell K, Fouquet H, Teulier S, Magnier R, Heyndrickx M, Lerouge D, Bergot E, Justet A. Étude D-CBP : Évaluation des délais de prise en charge du cancer broncho- pulmonaire au sein du service de Pneumologie et d’Oncologie Thoracique du CHU de Caen. Revue Des Maladies Respiratoires 2021, 38: 894-903. PMID: 34756617, DOI: 10.1016/j.rmr.2021.09.002.Peer-Reviewed Original ResearchConceptsLung cancerMedian diagnosis timeMedian treatment timeDepartment of PneumologyCancer-related deathsLung cancer treatmentPatient survivalSingle-centerMedian timeTreatment timeObservational studyPatientsCancer treatmentDiagnosis timeRespiratory departmentCancerLungTreatmentCancer PlanDaysPneumologyDiagnosis
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