2025
Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury
Wang W, Yang H, Wilson F, Gallagher M, Feng Y. Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury. Intensive And Critical Care Nursing 2025, 90: 104118. PMID: 40554252, DOI: 10.1016/j.iccn.2025.104118.Peer-Reviewed Original ResearchAcute kidney injuryNadir of riskPrimary outcomeSerum potassiumKidney injuryAKI progressionAssociated with AKI progressionOdds ratioHospitalized patientsAcute kidney injury durationAcute kidney injury patientsAssociation of hyperkalemiaMeasured serum potassiumOutcomes of hospitalized patientsSerum potassium levelsRestricted cubic spline regressionDays of randomizationAcute kidney injury progressionConfidence intervalsCubic spline regressionDose-response relationshipDischarged to homeOutcomes of interestsComposite outcomeHyperkalemiaAssociation of Kidney Biopsy Needle Gauge with Post-Procedure Complications and Biopsy Adequacy.
Staunton M, Garg K, Sadarangani S, Makhijani A, Shelton K, Koval E, Liang C, Shaw M, Kent C, Wilson F, Parikh C, Perazella M, Turner J, Luciano R, Moledina D. Association of Kidney Biopsy Needle Gauge with Post-Procedure Complications and Biopsy Adequacy. Kidney360 2025 PMID: 40402808, DOI: 10.34067/kid.0000000835.Peer-Reviewed Original ResearchOdds of complicationsKidney biopsyOutcomes of blood transfusionBiopsy-related complicationsPropensity score weighting analysisBleeding risk factorsG biopsy needlePost-procedural complicationsScore-weighted analysisHemoglobin dropAngiographic interventionBlood transfusionPost-procedureComplication riskUnivariate analysisAssess safetyComposite outcomeDiagnostic adequacyBiopsy adequacyBiopsyG needleMultivariate analysisComplicationsRisk factorsNeedle gaugeModifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome
Senff J, Tack R, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball T, Tan B, Chemali Z, Newhouse A, Kourkoulis C, Rivier C, Falcone G, Sheth K, Lazar R, Ibrahim S, Pikula A, Tanzi R, Fricchione G, Brouwers H, Rinkel G, Yechoor N, Rosand J, Anderson C, Singh S. Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome. Journal Of Neurology Neurosurgery & Psychiatry 2025, 96: 515-527. PMID: 40180437, DOI: 10.1136/jnnp-2024-334925.Peer-Reviewed Original ResearchConceptsModifiable risk factorsLate-life depressionDisability-adjusted life yearsMeta-analysesRisk factorsComposite outcomeRelevant meta-analysesBody mass indexPhysical activityIdentified risk factorsComposite outcome of strokeHearing lossIncidence of strokeDepressive symptomsPrevention strategiesLife yearsOutcome of strokeSystematic reviewInclusion criteriaMass indexDementiaFasting Plasma GlucoseEffect sizeSystematic literature reviewSocial engagementSevere Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis
Dahan S, Dal-Bianco J, Plakht Y, Namasivayam M, Capoulade R, Zeng X, Passeri J, Yucel E, Picard M, Levine R, Hung J. Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis. Circulation Cardiovascular Imaging 2025, 18: e017598. PMID: 40116009, DOI: 10.1161/circimaging.124.017598.Peer-Reviewed Original ResearchConceptsLow-gradient severe aortic stenosisParadoxical low-flowSevere aortic stenosisAortic valve replacementPRESERVED LEFT VENTRICULAR EJECTION FRACTIONSevere mitral regurgitationSevere MRVentricular ejection fractionAortic stenosisMitral regurgitationAll-Cause MortalityValve replacementMR degreeEjection fractionComposite outcomeAortic valve replacement ratesAssociated with adverse outcomesComplexity to diagnosisIncreased left ventricular dimensionsLow transaortic gradientNon-severe MRSevere MR groupHeart failure hospitalizationPropensity-adjusted modelLeft ventricular remodelingP0442 Prevalence and Impact of E-cigarettes on Disease Outcomes in Patients with Inflammatory Bowel Disease
Almuhaya H, Alashkar R, Alsebaai D, Albadawi N, Almutairdi A, Attamimi M, Desai S, Al-Bawardy B. P0442 Prevalence and Impact of E-cigarettes on Disease Outcomes in Patients with Inflammatory Bowel Disease. Journal Of Crohn's And Colitis 2025, 19: i951-i951. DOI: 10.1093/ecco-jcc/jjae190.0616.Peer-Reviewed Original ResearchTraditional cigarette smokingPrevalence of EC useClinical outcomesCrohn's diseaseEC useAdvanced therapiesIBD patientsCigarette smokingUlcerative colitisElectronic cigarettesPenetrating diseaseComposite outcomeIBD-unclassifiedHistory of intestinal surgeryAssociated with male sexFollow-up durationImpact of e-cigarettesDiagnosis of IBDCross-sectional studyCigarette smoking historyInflammatory bowel diseaseNo significant differencePerianal diseaseIBD registrySurgical interventionUtilizing preterm infant body composition assessments to guide neonatal nutrition
Buck C. Utilizing preterm infant body composition assessments to guide neonatal nutrition. Current Opinion In Pediatrics 2025, 37: 191-197. PMID: 39831772, PMCID: PMC11882371, DOI: 10.1097/mop.0000000000001434.Peer-Reviewed Original ResearchPreterm infantsBody composition assessmentHuman milk fortificationComposition assessmentBody composition assessment toolsBody composition outcomesBody composition changesEarly nutritional exposuresFat-free massParenteral nutritionNewborn periodPretermNeonatal nutritionComposite outcomeFormula supplementationLean massComposition assessment toolsInfant growthMilk fortificationNutritional exposuresEarly nutritionBody compositionRoutine useInfantsMuscle mass developmentWin Ratio Sensitivity Analysis Using A Modified Hierarchical Composite Outcome: Insights From The Paraglide-hf
Shoji S, Cyr D, Hernandez A, Morrow D, Velazquez E, Ward J, Williamson K, Sarwat S, Starling R, Desai A, Zieroth S, Solomon S, Braunwald E, Mentz R. Win Ratio Sensitivity Analysis Using A Modified Hierarchical Composite Outcome: Insights From The Paraglide-hf. Journal Of Cardiac Failure 2025, 31: 181. DOI: 10.1016/j.cardfail.2024.10.011.Peer-Reviewed Original ResearchNT-proBNPEjection fractionComposite outcomeRenal outcomesHeart failureN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideSacubitril/valsartan (sac/valWorsening HF eventsNT-proBNP changesClinically significant eventsNatriuretic peptideRandomized patientsAssessment of treatment effectsHF hospitalizationSac/ValHF patientsCardiovascular deathTreatment effectsHF eventsTreatment benefitComprehensive assessment of treatment effectsPatientsPrimary analysisHF visits
2024
Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury
Aklilu A, Menez S, Baker M, Brown D, Dircksen K, Dunkley K, Gaviria S, Farrokh S, Faulkner S, Jones C, Kadhim B, Le D, Li F, Makhijani A, Martin M, Moledina D, Coronel-Moreno C, O’Connor K, Shelton K, Shvets K, Srialluri N, Tan J, Testani J, Corona-Villalobos C, Yamamoto Y, Parikh C, Wilson F, Sundararajan A, Wang A, Schretlen C, Singel D, Moss E, Aune F, Iantosca G, Zou G, Chernova I, Bitzel J, Hernandez J, Lindsley J, Dane K, Orias M, Mehta P, Zassman-Isner S, Wen Y, Freeman N. Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury. JAMA 2024, 332: 2081-2090. PMID: 39454050, PMCID: PMC11669049, DOI: 10.1001/jama.2024.22718.Peer-Reviewed Original ResearchElectronic health recordsUsual careHealth recordsAction teamsClinicians of patientsHospitalized patientsFinal follow-upIntervention groupHealth systemStudy pharmacistsStudy physiciansMain OutcomesAssociated with adverse outcomesAcute kidney injuryRandomized clinical trialsPrimary outcomeIndividualized recommendationsNew HavenAdverse outcomesAKI detectionCareRhode IslandComposite outcomeFollow-upInterventionMachine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators
Rosman L, Lampert R, Wang K, Gehi A, Dziura J, Salmoirago-Blotcher E, Brandt C, Sears S, Burg M. Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators. Journal Of The American College Of Cardiology 2024, 85: 42-55. PMID: 39570241, DOI: 10.1016/j.jacc.2024.09.006.Peer-Reviewed Original ResearchImplantable cardioverter-defibrillatorYear of device implantationAll-Cause MortalityCardiac resynchronization therapyDeath/HF hospitalizationValidation cohortHeart failureDevice implantationTime of ICD implantationArea under the receiver-operating characteristic curveMedian Follow-UpReceiver-operating characteristic curvePredicting all-cause mortalityImplantable cardioverter-defibrillator patientsVeterans Health AdministrationPersonalized risk estimatesImplantable cardioverter defibrillatorResynchronization therapyBaseline demographicsICD implantationTraining cohortTrajectories of individual patientsProspective studyComposite outcomeContinuum of riskCorrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. Corrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1502482. PMID: 39600788, PMCID: PMC11589155, DOI: 10.3389/fpsyt.2024.1502482.Peer-Reviewed Original ResearchWin Ratio Analyses Using a Modified Hierarchical Composite Outcome: Insights From PARAGLIDE-HF
Shoji S, Cyr D, Hernandez A, Velazquez E, Ward J, Williamson K, Sarwat S, Starling R, Desai A, Zieroth S, Solomon S, Mentz R. Win Ratio Analyses Using a Modified Hierarchical Composite Outcome: Insights From PARAGLIDE-HF. American Heart Journal 2024, 280: 70-78. PMID: 39505123, DOI: 10.1016/j.ahj.2024.10.020.Peer-Reviewed Original ResearchNT-proBNPComposite outcomeRenal outcomesEjection fractionHeart failureN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideNT-proBNP thresholdsNT-proBNP changesClinically significant eventsNatriuretic peptideAssessment of treatment effectsHF hospitalizationCardiovascular deathTreatment effectsTreatment benefitComprehensive assessment of treatment effectsPrimary analysisValsartanHF visitsSecondary analysisPatientsHierarchical outcomesOutcomesLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsKidney Outcomes with Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas in Type 2 Diabetes and Moderate Cardiovascular Risk
Neumiller J, Herrin J, Swarna K, Polley E, Galindo R, Umpierrez G, Deng Y, Ross J, Mickelson M, McCoy R. Kidney Outcomes with Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas in Type 2 Diabetes and Moderate Cardiovascular Risk. Clinical Journal Of The American Society Of Nephrology 2024, 20: 206-217. PMID: 39729347, PMCID: PMC11835155, DOI: 10.2215/cjn.0000000587.Peer-Reviewed Original ResearchSodium-glucose co-transporter 2 inhibitorsGlucagon-like peptide-1 receptor agonistsSodium-glucose co-transporter 2Dipeptidyl peptidase-4 inhibitorsGlucagon-like peptide-1Dipeptidyl peptidase-4Receptor agonistsPrimary composite outcomeKidney replacement therapyChronic kidney diseaseComposite outcomeSecondary composite outcomeType 2 diabetesGLP-1 receptor agonist therapyCVD riskCardiovascular diseaseModerate CVD riskPrescribed glucose-lowering agentsBaseline CVD riskHigh-risk patientsAssociated with risk reductionCKD stage 3Retrospective observational studyGlucose-lowering agentsModerate cardiovascular riskLong-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry
Maurizi N, Antiochos P, Owens A, Lakdwala N, Saberi S, Russell M, Fumagalli C, Skalidis I, Lin K, Nathan A, De Feria Alsina A, Reza N, Stendahl J, Abrams D, Semsarian C, Clagget B, Lampert R, Wheeler M, Parikh V, Ashley E, Michels M, Rossano J, Ryan T, Ingles J, Ware J, Ho C, Helms A, Day S, Olivotto I. Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry. Circulation 2024, 150: 1377-1390. PMID: 39355918, PMCID: PMC11493522, DOI: 10.1161/circulationaha.124.069378.Peer-Reviewed Original ResearchSeptal reduction therapyHCM-related deathOutflow tract obstructionObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyHeart failureComposite outcomeMaximal left ventricular outflow tract gradientRecurrent left ventricular outflow tract obstructionRelief of outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionReduction therapyVentricular outflow tract obstructionDe novo atrial fibrillationPredictor of adverse outcomesOccurrence of heart failureAlcohol septal ablationOutflow tract gradientEvent-free survivalLong-term disease courseHypertrophic cardiomyopathy centersLong-term reliefCox proportional hazards modelsLong-term outcomesAssociation between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review
Javaheri A, Ozcan M, Moubarak L, Smoyer K, Rossulek M, Revkin J, Groarke J, Tarasenko L, Kosiborod M. Association between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review. Heliyon 2024, 10: e35916. PMID: 39229539, PMCID: PMC11369438, DOI: 10.1016/j.heliyon.2024.e35916.Peer-Reviewed Original ResearchGDF-15 concentrationsGrowth differentiation factor 15Differentiation factor 15GDF-15Heart failureMultivariate analysisRenal functionComposite outcomeAdverse outcomesOptimal treatment regimensPredictors of mortalityCardiovascular-related mortalityCross-sectional studyPrognostic roleTreatment regimensClinical risk prediction modelsPoor outcomeRisk prediction modelExercise capacityEligibility criteriaPatientsPRISMA guidelinesMortalityNonfatal outcomesOutcomesEstablishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants
Buck C, Santoro K, Shabanova V, Martin C, Taylor S. Establishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants. Pediatric Research 2024, 96: 1724-1731. PMID: 39069538, PMCID: PMC11772127, DOI: 10.1038/s41390-024-03439-2.Peer-Reviewed Original ResearchVery preterm infantsBody composition assessmentPreterm infantsPostmenstrual ageMarkers of metabolic healthFat distributionBedside ultrasoundCohort of very preterm infantsComposition assessmentWeeks' PMA,Metabolic healthIntra-rater intraclass correlation coefficientBrain growthBody composition metricsBody composition outcomesBedside ultrasound techniqueRegional fat distributionPoint of care ultrasoundIntraclass correlation coefficientPostmenstrual weeksMulticenter cohortRegional fatSubcutaneous fat distributionComposite outcomeSubcutaneous fat measurementsThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete dataAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart disease413-P: Comparative Effectiveness of Glucose-Lowering Agents on Kidney Outcomes in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk
NEUMILLER J, HERRIN J, SWARNA K, POLLEY E, GALINDO R, UMPIERREZ G, DENG Y, MICKELSON M, MCCOY R. 413-P: Comparative Effectiveness of Glucose-Lowering Agents on Kidney Outcomes in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk. Diabetes 2024, 73 DOI: 10.2337/db24-413-p.Peer-Reviewed Original ResearchPatient-Centered Outcomes Research InstituteModerate CVD riskKidney composite outcomeAssociated with lower riskGLP-1RACVD riskType 2 diabetesKidney outcomesComposite outcomeKidney diseaseLow riskHigh riskInitiation of kidney replacement therapyEffects of glucose-lowering agentsCardiovascular diseaseHigh risk of cardiovascular diseaseAssociated with increased riskBaseline CVD riskAssociated with higher riskRisk of cardiovascular diseaseGlucose-lowering agentsCare of peopleIncident kidney diseaseModerate cardiovascular riskTarget trial frameworkCare interruptions and mortality among adults in Europe and North America
Trickey A, Zhang L, Rentsch C, Pantazis N, Izquierdo R, Antinori A, Leierer G, Burkholder G, Cavassini M, Palacio-Vieira J, Gill M, Teira R, Stephan C, Obel N, Vehreschild J, Sterling T, Van Der Valk M, Bonnet F, Crane H, Silverberg M, Ingle S, Sterne J. Care interruptions and mortality among adults in Europe and North America. AIDS 2024, 38: 1533-1542. PMID: 38742863, PMCID: PMC11239093, DOI: 10.1097/qad.0000000000003924.Peer-Reviewed Original ResearchCare interruptionsMortality riskCohort studyHazard ratioAnalysis of cohort studiesAntiretroviral therapyCare of peopleRobust to sensitivity analysesMortality hazard ratioCrude mortality rateHazard of mortalityAntiretroviral therapy initiationObservational cohort studyAntiretroviral therapy startUninterrupted careFollow-up groupCareAssociated with adverse outcomesPWHCox regressionAdverse outcomesFollow-up timeMortality rateCompare hazardsComposite outcome
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