2021
Cardiac allograft vasculopathy: current review and future research directions
Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovascular Research 2021, 117: 2624-2638. PMID: 34343276, PMCID: PMC8783389, DOI: 10.1093/cvr/cvab259.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathyAllograft vasculopathyImmune-mediated vasculopathyLate graft lossGraft lossCardiac transplantationOrgan graftsTransplanted heartsCurrent therapiesVascular remodellingVasculopathyMajor causeCurrent reviewRemodellingTransplantationPathogenesisGraftTherapyPerfusionIncidenceDiagnosisVasculature
2020
Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection
Hu RW, Korutla L, Reddy S, Harmon J, Zielinski PD, Bueker A, Molina M, Romano C, Margulies K, McLean R, Lal P, Vallabhajosyula P. Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection. Transplantation Direct 2020, 6: e615. PMID: 33134491, PMCID: PMC7575166, DOI: 10.1097/txd.0000000000001057.Peer-Reviewed Original ResearchAntibody-mediated rejectionDonor exosomesEndomyocardial biopsyDonor heartsHuman leukocyte antigen (HLA) IHLA-I antibodiesRejection episodesTransplanted heartsComplement depositionI antibodiesPatientsClinical settingMRNA expressionAntigen IRejection typeTissue levelsI specificityProtein expressionTime pointsGold standardNoninvasive detectionAntibodiesTroponin proteinsBiopsyExosomes
1991
Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.
Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. American Journal Of Pathology 1991, 138: 791-8. PMID: 2012171, PMCID: PMC1886118.Peer-Reviewed Original ResearchConceptsHuman cardiac allograftsCoronary arteryT lymphocytesCardiac allograftsEndothelial cellsT cellsChronic immune reactionsDonor coronary arteriesRecipient T lymphocytesRegional immune responsesClass II major histocompatibility complexGraft endothelial cellsSmooth muscle cell proliferationAllogeneic T cellsAbility of HLAHuman arteriesLong-term survivalMuscle cell proliferationCoronary arterial endotheliumMajor histocompatibility complexNormal human arteriesTypical atherosclerosisOcclusive diseaseHLA-DRTransplanted hearts
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