Laura Bothwell, PhD, MA
Senior Lecturer in Epidemiology (Microbial Diseases)Cards
Appointments
Additional Titles
Assistant Professor, Epidemiology of Microbial Diseases
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Additional Titles
Assistant Professor, Epidemiology of Microbial Diseases
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Additional Titles
Assistant Professor, Epidemiology of Microbial Diseases
Affiliated Faculty, Yale Institute for Global Health
Contact Info
About
Titles
Senior Lecturer in Epidemiology (Microbial Diseases)
Assistant Professor, Epidemiology of Microbial Diseases; Affiliated Faculty, Yale Institute for Global Health
Biography
Dr. Bothwell is an ethicist and historian of public health. Her research examines social, historical, and ethical dimensions of epidemiology with a particular focus on randomized controlled trials (RCTs). Her current book project examines how international and national policies have influenced trial rigor and ethics, protections of vulnerable trial subjects, and participant diversity in RCTs. She also does work at the intersection of climate change, epidemiology, and ethics.
She completed a PhD in the History and Ethics of Public Health and Medicine from the Department of Sociomedical Sciences at Columbia University followed by a postdoctoral fellowship in Health Policy, Law, and Ethics in the Division of Pharmacoepidemiology and Pharmacoeconomics at Harvard Medical School and the Brigham and Women’s Hospital. She has also had visiting appointments at Oxford University, Foundation Brocher, the Karolinska Institutet, and National Taiwan University. She teaches public health ethics and the history of public health, and provides pre-departure ethics training in global health practice. She holds a secondary appointment in the Section of the History of Medicine at the Yale School of Medicine.
Appointments
Epidemiology of Microbial Diseases
Senior LecturerPrimaryHistory of Medicine
Assistant ProfessorSecondary
Other Departments & Organizations
- Climate Change and Health
- Epidemiology of Microbial Diseases
- Epidemiology of Microbial Diseases (EMD)
- History of Medicine
- Program for Biomedical Ethics
- Yale Institute for Global Health
- Yale School of Public Health
- Yale School of Public Health - NEW
Education & Training
- Postdoctoral Fellow
- Harvard Medical School and Brigham and Women’s Hospital (2016)
- PhD
- Columbia University, History and Ethics of Public Health and Medicine, Department of Sociomedical Sciences (2014)
- MPhil
- Columbia University, History and Ethics of Public Health and Medicine, Department of Sociomedical Sciences (2011)
- MA
- Union Theological Seminary, Concentration in History of Science and Religion (2006)
- BA
- College of St. Scholastica, History (2004)
Research
Overview
Medical Research Interests
Public Health Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Kimberly Yousey-Hindes, MPH
Randomized Controlled Trials as Topic
Adaptive Clinical Trials as Topic
Publications
Featured Publications
Social and Scientific History of Randomized Controlled Trials
Bothwell L, Kuo W, Jones D, Podolsky S. Social and Scientific History of Randomized Controlled Trials. 2020, 1-17. DOI: 10.1007/978-3-319-52677-5_196-1.Peer-Reviewed Original ResearchAltmetricConceptsSocietal forcesTechnological forcesEthical standardsHistorical contextScientific historyGenerations of investigatorsRigorous research methodsConceptual foundationsResearch methodsCommercial interestRecent expansionKey challengesChapter brieflyChallengesHistoryForceContextTrials todayPracticeFoundationEmergenceTodayHistorical useRigorInnovation and Tribulation in the History of Randomized Controlled Trials in Surgery
Bothwell L, Jones D. Innovation and Tribulation in the History of Randomized Controlled Trials in Surgery. Annals Of Surgery 2019, 274: e616-e624. PMID: 34784667, PMCID: PMC8600053, DOI: 10.1097/sla.0000000000003631.Peer-Reviewed Original ResearchCitationsAltmetricThe Real‐World Ethics of Adaptive‐Design Clinical Trials
Bothwell LE, Kesselheim AS. The Real‐World Ethics of Adaptive‐Design Clinical Trials. The Hastings Center Report 2017, 47: 27-37. PMID: 29171051, DOI: 10.1002/hast.783.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical equipoisePrimary ethical concernsMedical researchEthical approachEthical argumentsEthical justificationTrial control armEthical concernsEthicsAdaptive design clinical trialsTheoretical equipoiseCritical principlesEquipoiseAllocation of subjectsInferior treatmentProduct sponsorsArgumentCritical assessmentConventional RCTsAdditional concernsUseful standardActual trialAdaptive trialsJustificationClaimsAssessing the Gold Standard — Lessons from the History of RCTs
Bothwell LE, Greene JA, Podolsky SH, Jones DS. Assessing the Gold Standard — Lessons from the History of RCTs. New England Journal Of Medicine 2016, 374: 2175-2181. PMID: 27248626, DOI: 10.1056/nejmms1604593.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2022
Trends in disparities in COVID hospitalizations among community‐dwelling residents of two counties in Connecticut, before and after vaccine introduction, March 2020–September 2021
McWilliams C, Bothwell L, Yousey‐Hindes K, Hadler J. Trends in disparities in COVID hospitalizations among community‐dwelling residents of two counties in Connecticut, before and after vaccine introduction, March 2020–September 2021. Influenza And Other Respiratory Viruses 2022, 17: e13082. PMID: 36509459, PMCID: PMC9835416, DOI: 10.1111/irv.13082.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 hospitalizationNon-Hispanic blacksGeocoded residential addressesAge-adjusted incidenceNon-Hispanic whitesHispanic/LatinxVaccination ratesLaboratory-confirmed COVID-19Residential addressesSocioeconomic statusSurveillance Network databaseCommunity-dwelling residentsNon-institutionalized personsIntroduction of vaccinesLow socioeconomic statusCensus tract measuresRace/ethnicityLower SES groupsVaccine registryVaccine introductionVaccination levelsHospitalizationVaccine rolloutDelta wavesSES disparitiesSocial and Scientific History of Randomized Controlled Trials
Bothwell L, Kuo W, Jones D, Podolsky S. Social and Scientific History of Randomized Controlled Trials. 2022, 3-19. DOI: 10.1007/978-3-319-52636-2_196.Peer-Reviewed Original ResearchConceptsSocietal forcesTechnological forcesEthical standardsHistorical contextScientific historyGenerations of investigatorsRigorous research methodsConceptual foundationsResearch methodsCommercial interestRecent expansionKey challengesChapter brieflyChallengesHistoryForceContextTrials todayPracticeFoundationEmergenceTodayHistorical useRigor
2021
Bioethical Issues in Pharmacoepidemiologic Research
Bothwell L, Richterich A, Greene J. Bioethical Issues in Pharmacoepidemiologic Research. 2021, 276-293. DOI: 10.1002/9781119701101.ch16.Peer-Reviewed Original ResearchConceptsField of bioethicsResearch ethics policiesGood Pharmacoepidemiology PracticesPharmacoepidemiologic researchEthical conceptsEthics policiesEthical policiesBioethical issuesBioethical principlesField of pharmacoepidemiologyInternational SocietyGlobal settingBioethicsPolicyPracticeConductKey elementsEuropean NetworkMedical therapeuticsSocietyKey challengesConceptPrinciplesResearchRecent developmentsInnovation and Tribulation in the History of Randomized Controlled Trials in Surgery
Bothwell LE, Jones DS. Innovation and Tribulation in the History of Randomized Controlled Trials in Surgery. Annals of Surgery 2021, 274 (6): e616-e624.Peer-Reviewed Original Research
2020
Social and Scientific History of Randomized Controlled Trials
Bothwell LE, Kuo W-H, Jones DS, Podolsky, SH. Social and Scientific History of Randomized Controlled Trials. In Principles and Practice of Clinical Trials. Ed. S. Piantadosi and C. Meinert. Springer, 2020.Books
2019
Bioethical Issues in Pharmacoepidemiologic Research
Bothwell L, Richterich A, Greene J. Bioethical Issues in Pharmacoepidemiologic Research. 2019, 772-791. DOI: 10.1002/9781119413431.ch31.Peer-Reviewed Original ResearchConceptsBioethical issuesField of bioethicsTechnologies of surveillancePharmacoepidemiologic researchSociological perspectiveEthical approachSociological dimensionsBioethical principlesField of pharmacoepidemiologyNational variationsInternational perspectivePerspectiveChapter brieflyBioethicsIssuesResearchMedical therapeuticsAttentionRecent yearsCommonalitiesPrinciplesData analysisRecent developmentsBrieflyDimensions
News
News
- October 18, 2023
For YSPH student, creating suicide prevention guide both an academic and personal project
- April 18, 2023
New Haven students learn about public health at Yale science fair
- March 09, 2023Source: MDedge: Hematology and Oncology
Cancer clinical trials: Can industry stack the deck?
- January 26, 2023
Faculty Spotlight: Laura Bothwell