Barbara Burtness, MD

Professor of Medicine (Medical Oncology); Disease Aligned Research Team Leader, Head and Neck Cancers Program; Co-Director, Developmental Therapeutics Research Program

Research Departments & Organizations

Internal Medicine: Medical Oncology: Subset Medical Oncology Faculty

Status of Women in Medicine Committee (SWIM)

Yale Cancer Center: Developmental Therapeutics

Research Interests

Analytical, Diagnostic and Therapeutic Techniques and Equipment; Chemicals and Drugs; Drug Therapy; Head and Neck Neoplasms; Medical Oncology

Research Summary

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, including studies of treatment deintensification in HPV-associated cancer, and molecularly guided post-operative therapy. She chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer.

Specialized Terms: EGFR expressed head and neck cancers.

Extensive Research Description

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She has demonstrated that loss of PTEN indicates resistance to EGFR inhibition in head and neck cancer, and studied novel dual EGFR/HDAC inhibitors and combined antibody and tyrosine kinase inhibition as strategies to improve responsiveness to EGFR inhibition. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, and chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer. Her laboratory studies novel combinatorial therapies to target p53 mutated head and neck cancer.

Clinical Trials

Conditions Study Title
Thyroid A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior VEGFR-Targeted Therapy
Other Skin A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants With High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630)
Esophagus, Larynx, Lip, Oral Cavity and Pharynx Randomized Phase II/III Trial of Radiotherapy With Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy With Concurrent Cetuximab in Patients With Locoregionally Advanced Head and Neck Cancer With a Contraindication to Cisplatin
Lung A Phase 1/2 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors With RET Activation (LIBRETTO-001)
Lip, Oral Cavity and Pharynx Phase 1a/2a Dose Escalation Trial to Determine Safety, Tolerance, MTD, and Preliminary Antineoplastic Activity of AVID100, in Patients With Advanced or Metastatic Solid Tumors of Epithelial Origin
Urinary Bladder Renalase agonists to prevent cisplatin-induced kidney toxicity to improve cancer therapy
Larynx, Lip, Oral Cavity and Pharynx A Phase I Study of M6620 (VX-970) in Combination With Cisplatin and XRT in Patients With Locally Advanced HPV (-) Head and Neck Squamous Cell Carcinoma (HNSCC; SDC 10060121)
Lip, Oral Cavity and Pharynx Phase II Randomized Trial of Neo-Adjuvant Chemotherapy Followed by Surgery and Post-Operative Radiation Versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC)
Other Skin A Phase 2, Open-Label, Single Arm Study to Evaluate the Safety and Efficacy of Pembrolizumab in Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC)
Phase I An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Larynx, Lip, Oral Cavity and Pharynx Single-Arm Phase II Trial of Dual Inhibition of EGFR With Afatinib and Cetuximab With Correlative Studies in the Second-Line Treatment of Recurrent or Metastatic Squamous Cell Cancers of the Head and Neck
Larynx, Lip, Oral Cavity and Pharynx, Ill-Defined Sites A Phase II Study of Pembrolizumab for Patients With Head and Neck Squamous Cell Carcinoma With Residual Disease Following Definitive Chemoradiation
Anus, Bones and Joints, Brain and Nervous System, Breast - Female, Breast - Male, Colon, Corpus Uteri, Esophagus, Eye and Orbit, Hodgkin's Lymphoma, Kaposi's sarcoma, Kidney, Larynx, Lip, Oral Cavity and Pharynx, Liver, Lung, Lymphoid Leukemia, Melanoma, skin, Non-Hodgkin's Lymphoma, Other Digestive Organ, Other Endocrine System, Other Female Genital, Other Male Genital, Other Respiratory and Intrathoracic Organs, Other Skin, Other Urinary, Ovary, Pancreas, Prostate, Rectum, Small Intestine, Soft Tissue, Stomach, Thyroid, Cervix, Urinary Bladder NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors or Lymphomas
Larynx, Lip, Oral Cavity and Pharynx Phase II Randomized Trial of Adjuvant Radiotherapy With or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Lip, Oral Cavity and Pharynx Window Trial 5-aza in HNSCC, T-tare
Lip, Oral Cavity and Pharynx Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Selected Publications

See list of PubMed publications

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Coauthors

David Rimm

Contact Info

Barbara Burtness, MD
Mailing Address
Medical Oncology25 York Street
PO Box 208028

New Haven, CT 06520-8028