2013
Endothelial Cell–Dependent Regulation of Arteriogenesis
Moraes F, Paye J, Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M. Endothelial Cell–Dependent Regulation of Arteriogenesis. Circulation Research 2013, 113: 1076-1086. PMID: 23897694, PMCID: PMC3865810, DOI: 10.1161/circresaha.113.301340.Peer-Reviewed Original ResearchConceptsAdult arteriogenesisCell-autonomous fashionGrowth factor signalingMouse linesCell-autonomous effectsKnockin mouse lineMorphogenetic defectsArterial morphogenesisCell type-specific deletionFactor signalingCell typesCre-driver mouse linesSynectinAttractive therapeutic strategyOcclusive atherosclerotic diseaseMuscle cellsEndothelial cellsRegulationArterial conduitsAtherosclerotic diseaseTherapeutic strategiesAdult miceClinical importanceArteriogenesisCells
2012
Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency
Christoffersson G, Zang G, Zhuang ZW, Vågesjö E, Simons M, Phillipson M, Welsh M. Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency. Angiogenesis 2012, 15: 469-480. PMID: 22562363, PMCID: PMC4059510, DOI: 10.1007/s10456-012-9275-z.Peer-Reviewed Original ResearchConceptsShb knockout mouseWild-type situationShb adapter proteinPatho-physiological responsesKnockout miceAdapter proteinAdherens junctionsShb deficiencyFunction of VEGFVE-cadherinVivo angiogenesisPhysiological conditionsAltered propertiesReceptor VEGFR-2Growth factorVascular endothelial growth factorVEGFR-2
2010
VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M. VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis. Developmental Cell 2010, 18: 713-724. PMID: 20434959, PMCID: PMC2875289, DOI: 10.1016/j.devcel.2010.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesCarrier ProteinsCell MembraneEndocytosisEndothelium, VascularGene SilencingMiceMice, KnockoutMorphogenesisMyosin Heavy ChainsNeuropeptidesPhosphorylationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishConceptsArterial morphogenesisSelective dephosphorylationPlasma membraneIntracellular traffickingKey growth factorsNull phenotypeMyosin VIMolecular eventsMorphogenesisVEGFR2 activationTraffickingIntracellular sitesKey eventsPTP1BNull miceKnockdownImpaired VEGFGrowth factorVEGFR2ActivationDephosphorylationEndosomesVEGFPhosphorylationSites