Featured Publications
Hepatic lymphatic vascular system in health and disease
Jeong J, Tanaka M, Iwakiri Y. Hepatic lymphatic vascular system in health and disease. Journal Of Hepatology 2022, 77: 206-218. PMID: 35157960, PMCID: PMC9870070, DOI: 10.1016/j.jhep.2022.01.025.Peer-Reviewed Original ResearchConceptsLiver diseaseNon-alcoholic fatty liver diseaseLymphatic systemFatty liver diseaseCongenital liver diseasesPotential therapeutic strategyHepatic lymphatic systemLiver transplantationPortal hypertensionMalignant tumorsTherapeutic strategiesDisease pathogenesisHepatic physiologyDiseasePathological conditionsSpecific markersLymphatic vesselsVascular systemLymphatic vascular systemOrgansTissue homeostasisHypertensionTransplantationPathophysiologyPathogenesis
2020
Pathophysiology of Portal Hypertension
Iwakiri Y, Groszmann R. Pathophysiology of Portal Hypertension. 2020, 659-669. DOI: 10.1002/9781119436812.ch51.Peer-Reviewed Original ResearchPortal hypertensionGastroesophageal variceal hemorrhageHyperdynamic circulatory syndromeIntrahepatic portal hypertensionNew blood vessel formationPre-existing vascular bedExtrahepatic circulationVariceal hemorrhageCirculatory syndromeLiver cirrhosisLethal complicationVascular toneVascular bedHypertensionFrequent causeCell-specific modulationPlatelet activationBlood vessel formationOrgans/tissuesVasoconstrictor moleculesCirrhosisTherapeutic purposesVessel formationPathophysiologySubsequent development
2015
Nitric oxide in liver diseases
Iwakiri Y, Kim MY. Nitric oxide in liver diseases. Trends In Pharmacological Sciences 2015, 36: 524-536. PMID: 26027855, PMCID: PMC4532625, DOI: 10.1016/j.tips.2015.05.001.BooksConceptsLiver sinusoidal endothelial cellsEndothelial NO synthaseLiver diseaseNitric oxideSinusoidal endothelial cellsInducible NOSNO synthaseEndothelial cellsPathological processesDiseaseDisease developmentLiverFatty acidsS-guanylationComplicated rolePathophysiologyPathogenesisNOSProgressionImportant role
2014
Pathophysiology of Portal Hypertension
Iwakiri Y. Pathophysiology of Portal Hypertension. Clinics In Liver Disease 2014, 18: 281-291. PMID: 24679494, PMCID: PMC3971388, DOI: 10.1016/j.cld.2013.12.001.BooksConceptsPortal hypertensionBlood flowHyperdynamic circulatory syndromeIntrahepatic vascular resistancePortal blood flowVascular resistanceArterial vasodilationCirculatory syndromeEsophageal varicesLiver cirrhosisMajor complicationsLiver diseaseCollateral vesselsPortal circulationSystemic circulationHypertensionPathologic conditionsClinical researchCirrhosisVaricesVasodilationAscitesComplicationsPathophysiologySyndromePathophysiology of Portal Hypertension
Iwakiri Y, Groszmann R. Pathophysiology of Portal Hypertension. 2014, 3-14. DOI: 10.1007/978-1-4939-0002-2_1.Peer-Reviewed Original ResearchPortal hypertensionLiver diseaseHyperdynamic splanchnic circulationHepatic vascular resistanceSerious liver diseaseExtrahepatic diseaseGastroesophageal varicesVascular resistanceHemodynamic abnormalitiesSplanchnic circulationLethal complicationCirculatory derangementsHypertensionDiseaseCurrent knowledgeVaricesAscitesComplicationsHemorrhageDerangementPathophysiologyRegulatory mechanismsAbnormalitiesFunctional aspects