Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevance
2024
The profile of blood microbiome in new-onset type 1 diabetes children
Yuan X, Yang X, Xu Z, Li J, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Fu J, Wu J, Chen Z, Fang X, Su Z, Zhang M, Wu J, Chen X, Zhou J, Luo Y, Zhang L, Wang R, Luo F. The profile of blood microbiome in new-onset type 1 diabetes children. IScience 2024, 27: 110252. PMID: 39027370, PMCID: PMC11255850, DOI: 10.1016/j.isci.2024.110252.Peer-Reviewed Original ResearchBlood microbiomeRRNA gene sequencesMicrobiome of patientsGene sequencesOral microbiomePICRUSt analysisMicrobial featuresMicrobiome signaturesPathogenic bacteriaMicrobiomeTranslocation of bacteriaPotential translocationBacteriaRandom forest analysisType 1 diabetic childrenGutNew-onset T1DDiscriminatory powerType 1 diabetesForest analysisOral cavityIncreasing diversityInduce inflammationPICRUStGenus