Featured Publications
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs
2019
The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer
Wu M, Leng W, Pan H, Lei X, Chen L, Ouyang X, Liang Z. The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer. Mediators Of Inflammation 2019, 2019: 6705424. PMID: 31007603, PMCID: PMC6441532, DOI: 10.1155/2019/6705424.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersCourse of diseaseInterleukin-6Diabetes mellitusFoot ulcersWound groupChronic diabetic foot ulcersChronic wound groupsReduced expressionUncontrolled chronic inflammationRelevant clinical dataExpression of NFResults of immunofluorescenceChronic inflammationInflammatory pathwaysIntractable complicationClinical dataImmunohistochemical stainingRefractory woundsInflammatory regulationInflammationUlcersPatientsAW groupUncontrolled activation