Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Science 2020, 369: 320-325. PMID: 32675374, DOI: 10.1126/science.aay9733.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesAutoantibodiesAutoantigensAutoimmunityBacteriaB-LymphocytesFemaleFetusHumansImmunity, InnateOrgan SpecificityPregnancyV(D)J RecombinationConceptsB cell toleranceB cellsCell toleranceEarly human fetal lifeHuman fetal B cellsPolyreactive B cellsHuman fetal lifeApoptotic cellsFetal B cellsHuman fetal liverB cell specificitySingle B cellsAbundant autoantibodiesGut microbiota assemblyNewborn seraFetal lifeBone marrowFetal developmentHealthy adultsCommensal bacteriaRepertoire breadthMicrobiota assemblyFetal liverPreimmune repertoireCell specificity