2023
Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2023, 3: 1603-1603. PMID: 38001312, DOI: 10.1038/s43587-023-00544-5.Peer-Reviewed Original ResearchContinuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus
Phan D, Dahl P, Koundal S, Pedram M, Deniz E, Benveniste H, Malvankar N, Kahle K. 195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus. Neurosurgery 2023, 69: 32-32. DOI: 10.1227/neu.0000000000002375_195.Peer-Reviewed Original ResearchVentricular dilationCongenital hydrocephalusCongenital brain malformationsHuman congenital hydrocephalusCerebrospinal fluid circulationNeural stem cell proliferationCortical hypoplasiaAqueductal obstructionBrain parenchymaBrain malformationsMouse modelHydrocephalus patientsNeurogenesis resultsVentricular expansionNeural stem cell fateCSF circulationIntracranial physiologyCSF flowGenetic subtypesPrimary physiological factorCSF dynamicsCell proliferationCSFSame point mutationHydrocephalusThe choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Robert S, Reeves B, Kiziltug E, Duy P, Karimy J, Mansuri M, Marlier A, Allington G, Greenberg A, DeSpenza T, Singh A, Zeng X, Mekbib K, Kundishora A, Nelson-Williams C, Hao L, Zhang J, Lam T, Wilson R, Butler W, Diluna M, Feinberg P, Schafer D, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick D, Schiff S, Carter B, Gunel M, Simard J, Lifton R, Alper S, Delpire E, Kahle K. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 2023, 186: 764-785.e21. PMID: 36803604, PMCID: PMC10069664, DOI: 10.1016/j.cell.2023.01.017.Peer-Reviewed Original ResearchConceptsPost-infectious hydrocephalusTLR4-dependent immune responseBlood-cerebrospinal fluid barrierSmall molecule pharmacotherapyCell cross talkPharmacological immunomodulationCytokine stormNeuroimmune disordersBrain infectionDrug treatmentImmune responseAcquired hydrocephalusHydrocephalus modelChoroid plexusFluid barrierHydrocephalusEpithelial cellsCSFMulti-omics investigationsCross talkHypersecretionHemorrhagePharmacotherapyImmunomodulationPlexus
2022
Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling
Lee H, Ozturk B, Stringer MS, Koundal S, MacIntosh BJ, Rothman D, Benveniste H. Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling. NeuroImage 2022, 261: 119512. PMID: 35882269, PMCID: PMC9969358, DOI: 10.1016/j.neuroimage.2022.119512.Peer-Reviewed Original ResearchConceptsWater flowBlood perfusionLow-dose isofluraneCerebral blood flowClinical translational studiesAnti-diuretic hormoneContinuous arterial spinLevels of bloodMeasurement accuracyMagnetic resonance imagingArterial spin labelingCerebrospinal fluid productionAnesthetic regimensBalanced anesthesiaCerebral ventricleContinuous arterial spin labelingIsoflurane anesthesiaKey parametersSystemic administrationVentricular CSFImmune surveillanceArterial bloodBlood flowTissue perfusionChoroid plexusCharacterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging
Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1813-1826. PMID: 35673963, PMCID: PMC9536121, DOI: 10.1177/0271678x221105668.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseCerebral small vessel diseaseT2W magnetic resonance imagesSHRSP ratsPerivascular spacesClinical relevanceMagnetic resonance imagesVessel diseaseSeverity of SVDGadoteric acidWistar-Kyoto control ratsHypertensive stroke-prone ratsStroke-prone ratsHuman post-mortem tissueT2-weighted magnetic resonance imagesMonths of ageT1-weighted imagingMagnetic resonance imagingPost-mortem tissueVivo magnetic resonance imagingPrimary endpointHyperintense lesionsProne ratsWKY ratsUnderlying pathophysiologyStudies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy
Koundal S, Gandhi S, Khushu S. Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy. Biomarkers 2022, 27: 562-567. PMID: 35532034, DOI: 10.1080/1354750x.2022.2076152.Peer-Reviewed Original ResearchConceptsHypobaric hypoxiaHypobaric hypoxia equivalentSerum metabolic changesPreclinical rat modelAmino acid metabolitesHigh-altitude hypoxiaHypoxia equivalentRat modelMetabolic alterationsHealth problemsKetone bodiesMultivariate analysisAcid metabolitesAltitude hypoxiaSerum samplesEarly detectionMetabolic changesHypoxiaMetabolism of membranePresent findingsSerumAlterationsCellular bioenergeticsPresent studyEnvironmental hypoxiaPublisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2022, 2: 454-454. PMID: 37118076, DOI: 10.1038/s43587-022-00223-x.Peer-Reviewed Original ResearchImpaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience 2022, 25: 458-473. PMID: 35379995, PMCID: PMC9664907, DOI: 10.1038/s41593-022-01043-3.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusCerebral ventricular dilatationPrimary defectNeuroepithelial cell differentiationRisk genesCerebrospinal fluid homeostasisWhole-exome sequencingNeuroepithelial stem cellsCortical hypoplasiaReduced neurogenesisVentricular dilatationVentricular enlargementCH mutationsPrenatal hydrocephalusDisease heterogeneityBrain surgeryCSF circulationHydrocephalusGenetic subtypesFluid homeostasisNeuroepithelial cellsNovo mutationsBrain transcriptomicsStem cellsCell differentiation
2020
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System
Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Van Nostrand W, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A. Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System. Scientific Reports 2020, 10: 1990. PMID: 32029859, PMCID: PMC7004986, DOI: 10.1038/s41598-020-59045-9.Peer-Reviewed Original Research
2017
Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study
Singh K, Trivedi R, Verma A, D'souza M, Koundal S, Rana P, Baishya B, Khushu S. Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study. NMR In Biomedicine 2017, 30 PMID: 28759166, DOI: 10.1002/nbm.3764.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryDay 1Metabolic alterationsDay 5Moderate traumatic brain injuryPathological processesN-acetylaspartate levelsTrauma-induced changesSeverity of injuryProton magnetic resonance spectroscopy dataRat hippocampusGlutamine/glutamateHippocampus regionTBI groupAltered metabolitesHigher cognitive functionsCognitive functionInjuryMetabolic irregularitiesAmino acid metabolismCitric acid cycle intermediatesAltered levelsMetabolic profileOxidative stress
2015
“Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia
Koundal S, Gandhi S, Kaur T, Mazumder A, Khushu S. “Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia. OMICS A Journal Of Integrative Biology 2015, 19: 757-765. PMID: 26669710, DOI: 10.1089/omi.2015.0155.Peer-Reviewed Original ResearchConceptsHypobaric hypoxiaSports medicineHypobaric hypoxia exposurePreclinical rat modelHigh altitude medicineAltitude medicineCell membrane metabolismUse of metabolomicsUrinary metabolomeHepatic functionLiver histopathologyRat modelLiver functioningHypoxia exposureHealth problemsMultivariate analysisPotential biomarkersAttendant health problemsTCA cycle metabolitesBiomarker studiesHypoxiaUrine samplesTaurine metabolismMembrane metabolismCycle metabolitesInvestigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T
Koundal S, Gandhi S, Kaur T, Trivedi R, Khushu S. Investigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T. Neuroscience 2015, 289: 106-113. PMID: 25592421, DOI: 10.1016/j.neuroscience.2014.12.049.Peer-Reviewed Original ResearchConceptsCorpus callosumDiffusion tensor imagingHH exposureADC valuesEdema formationT2 relaxometryGroups of ratsApparent diffusion coefficient (ADC) changesCytotoxic edema formationHypoxia-induced changesWater diffusion changesCytotoxic edemaHippocampal regionRat brainHH groupT2 valuesIron depositionTensor imagingRatsMagnetic resonance imaging modalitiesImaging modalitiesDiffusion changesHippocampusDiffusion tensorMRI modalities
2014
Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T
Koundal S, Gandhi S, Kaur T, Khushu S. Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T. NMR In Biomedicine 2014, 27: 341-347. PMID: 24395642, DOI: 10.1002/nbm.3068.Peer-Reviewed Original ResearchConceptsAcute hypobaric hypoxiaHypobaric hypoxiaRat brainHH exposureCA2/CA3 regionDays of normoxiaMetabolite levelsProcess of demyelinationMyo-inositol levelsDays post exposureVivo 1H MRSEarly risk assessmentGlutamatergic neuronsNeurometabolic changesAstrocyte metabolismCA3 regionN-acetylaspartateHippocampus regionMetabolic alterationsPost exposureMetabolic changesNormoxiaBrainFourth dayFirst day