2022
Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging
Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1813-1826. PMID: 35673963, PMCID: PMC9536121, DOI: 10.1177/0271678x221105668.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral Small Vessel DiseasesGlymphatic SystemHumansMagnetic Resonance ImagingRatsRats, Inbred WKYStrokeConceptsSmall vessel diseaseCerebral small vessel diseaseT2W magnetic resonance imagesSHRSP ratsPerivascular spacesClinical relevanceMagnetic resonance imagesVessel diseaseSeverity of SVDGadoteric acidWistar-Kyoto control ratsHypertensive stroke-prone ratsStroke-prone ratsHuman post-mortem tissueT2-weighted magnetic resonance imagesMonths of ageT1-weighted imagingMagnetic resonance imagingPost-mortem tissueVivo magnetic resonance imagingPrimary endpointHyperintense lesionsProne ratsWKY ratsUnderlying pathophysiology
2020
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System
Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Van Nostrand W, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A. Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System. Scientific Reports 2020, 10: 1990. PMID: 32029859, PMCID: PMC7004986, DOI: 10.1038/s41598-020-59045-9.Peer-Reviewed Original Research
2015
Investigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T
Koundal S, Gandhi S, Kaur T, Trivedi R, Khushu S. Investigation of prolonged hypobaric hypoxia-induced change in rat brain using T2 relaxometry and diffusion tensor imaging at 7T. Neuroscience 2015, 289: 106-113. PMID: 25592421, DOI: 10.1016/j.neuroscience.2014.12.049.Peer-Reviewed Original ResearchConceptsCorpus callosumDiffusion tensor imagingHH exposureADC valuesEdema formationT2 relaxometryGroups of ratsApparent diffusion coefficient (ADC) changesCytotoxic edema formationHypoxia-induced changesWater diffusion changesCytotoxic edemaHippocampal regionRat brainHH groupT2 valuesIron depositionTensor imagingRatsMagnetic resonance imaging modalitiesImaging modalitiesDiffusion changesHippocampusDiffusion tensorMRI modalities