2022
Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy
Koundal S, Gandhi S, Khushu S. Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy. Biomarkers 2022, 27: 562-567. PMID: 35532034, DOI: 10.1080/1354750x.2022.2076152.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersHypoxiaMagnetic Resonance SpectroscopyMetabolomicsProton Magnetic Resonance SpectroscopyRatsConceptsHypobaric hypoxiaHypobaric hypoxia equivalentSerum metabolic changesPreclinical rat modelAmino acid metabolitesHigh-altitude hypoxiaHypoxia equivalentRat modelMetabolic alterationsHealth problemsKetone bodiesMultivariate analysisAcid metabolitesAltitude hypoxiaSerum samplesEarly detectionMetabolic changesHypoxiaMetabolism of membranePresent findingsSerumAlterationsCellular bioenergeticsPresent studyEnvironmental hypoxia
2015
“Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia
Koundal S, Gandhi S, Kaur T, Mazumder A, Khushu S. “Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia. OMICS A Journal Of Integrative Biology 2015, 19: 757-765. PMID: 26669710, DOI: 10.1089/omi.2015.0155.Peer-Reviewed Original ResearchConceptsHypobaric hypoxiaSports medicineHypobaric hypoxia exposurePreclinical rat modelHigh altitude medicineAltitude medicineCell membrane metabolismUse of metabolomicsUrinary metabolomeHepatic functionLiver histopathologyRat modelLiver functioningHypoxia exposureHealth problemsMultivariate analysisPotential biomarkersAttendant health problemsTCA cycle metabolitesBiomarker studiesHypoxiaUrine samplesTaurine metabolismMembrane metabolismCycle metabolites