2023
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Rodriguez Tirado C, Wang C, Li X, Deng S, Gonzalez J, Johnson N, Xu Y, Metang L, Sundar Rajan M, Yang Y, Yin Y, Hofstad M, Raj G, Zhang S, Lemoff A, He W, Fan J, Wang Y, Wang T, Mu P. UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. Oncogene 2023, 43: 265-280. PMID: 38030789, PMCID: PMC10798893, DOI: 10.1038/s41388-023-02890-5.Peer-Reviewed Original ResearchConceptsAberrant androgen receptorProstate cancerAR ubiquitinationAR degradationAntiandrogen therapyResistance to antiandrogen therapyE2 ubiquitin-conjugating enzymeEnhanced AR signalingAndrogen receptor degradersAR protein levelsProstate cancer patientsUbiquitin-conjugating enzymeResistant tumorsPCa tumorsAR signalingAndrogen receptorAntiandrogen treatmentAntiandrogen resistanceAR proteinReceptor degradationProtein levelsOncogenic proteinsTumorTherapyProtein degradation process
2017
The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Amin E, Liu Y, Deng S, Tan K, Chudgar N, Mayo M, Sanchez-Vega F, Adusumilli P, Schultz N, Jones D. The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. Science Signaling 2017, 10 PMID: 28928239, PMCID: PMC5771642, DOI: 10.1126/scisignal.aah3941.Peer-Reviewed Original ResearchConceptsFocal adhesion kinaseRNA editing enzyme ADARPresence of ADARsAnalysis of gene expression patternsGenome-wide studiesLung adenocarcinoma cellsRNA-binding proteinsCell migration pathwaysGene expression patternsStabilized transcriptsIntron sitesADARProtein abundanceBinding proteinIncreased abundanceExpression patternsMolecular analysisStage I LUAD patientsPharmacological inhibitionProteinMesenchymal propertiesPotential therapeutic applicationsProtein levelsTranscriptionGenes