2020
The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size
Deng S, Silimon R, Balakrishnan M, Bothe I, Juros D, Soffar D, Baylies M. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. Developmental Biology 2020, 469: 12-25. PMID: 32980309, PMCID: PMC8279456, DOI: 10.1016/j.ydbio.2020.09.014.Peer-Reviewed Original ResearchConceptsActin thin filamentsFlightless IRegulate thin filament lengthContractile unit of muscleControl actin dynamicsActin polymerization factorsThin filamentsDrosophila flight muscleMyosin thick filamentsThin filament lengthSarcomere sizeActin regulatorsActin dynamicsFlight musclesThick filamentsActinMuscle developmentFilament lengthContractile unitsPolymerization factorsFunction of muscle fibersFilamentsSarcomereRegulationFormin
2016
Diaphanous regulates SCAR complex localization during Drosophila myoblast fusion
Deng S, Bothe I, Baylies M. Diaphanous regulates SCAR complex localization during Drosophila myoblast fusion. Fly 2016, 10: 178-186. PMID: 27314572, PMCID: PMC5036928, DOI: 10.1080/19336934.2016.1195938.Peer-Reviewed Original ResearchConceptsArp2/3 activationMyoblast fusionFusion siteSCAR activityDrosophila myoblast fusionBranched actin networksRegulate actin dynamicsActin cytoskeletal rearrangementDrosophila to manExtra View articleLoss of SCARCell-cell fusionOrganizing actinActin dynamicsActin rearrangementActin networkCytoskeletal rearrangementsSite of fusionMultinucleated muscle cellsActinComplex localizationDrosophilaWaspsView articleModel system
2014
PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development 2014, 141: 2289-2301. PMID: 24821989, PMCID: PMC4034421, DOI: 10.1242/dev.100743.Peer-Reviewed Original ResearchMeSH KeywordsActin-Related Protein 2-3 ComplexActinsAnimalsCell CommunicationCell MembraneCytoskeletonDrosophila melanogasterGene Expression Regulation, DevelopmentalGenotypeMuscle Fibers, SkeletalMutationMyoblastsPhosphatidylinositol 4,5-DiphosphatePhospholipidsRac GTP-Binding ProteinsSignal TransductionConceptsF-actinRegulation of F-actin dynamicsActivator of actin polymerizationFusion siteF-actin fociMyoblast fusionF-actin dynamicsRegulation of actinCell-cell fusionActin regulatorsActin fociActin remodelingActin polymerizationPhosphoinositide PI(4,5)P2Regulates localizationCytoskeleton signalingOpposing membranesPI(4,5)P2ActinImpaired fusionArp2/3Receptor engagementCytoskeletonRegulationEnrichment