2023
Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee P, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro H, Ju H, Liao C, Tieze S, Rigo F, Jafar-Nejad P, Lim J. Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Journal Of Clinical Investigation 2023, 133: e138207. PMID: 37384409, PMCID: PMC10425213, DOI: 10.1172/jci138207.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisTDP-43-related neurodegenerationNeurodegenerative disordersTransactive response DNA-binding protein 43Sporadic amyotrophic lateral sclerosisDNA-binding protein 43Subset of patientsTDP-43 speciesTDP-43 inclusionsDistinct mouse modelsTDP-43 proteinopathyFamilial amyotrophic lateral sclerosisNemo-like kinaseMultiple neurodegenerative disordersAutophagy/lysosome pathwayTDP-43-positive aggregatesALS patientsALS casesSporadic ALSPharmacological reductionProtein 43Lateral sclerosisMouse modelParkinson's diseaseTDP-43BioSentinel: Validating Sensitivity of Yeast Biosensors to Deep Space Relevant Radiation
Liddell L, Gentry D, Gilbert R, Marina D, Tieze S, Padgen M, Akiyama K, Keenan K, Bhattacharya S, Santa Maria S. BioSentinel: Validating Sensitivity of Yeast Biosensors to Deep Space Relevant Radiation. Astrobiology 2023, 23: 648-656. PMID: 37052477, PMCID: PMC10254971, DOI: 10.1089/ast.2022.0124.Peer-Reviewed Original Research
2020
BioSentinel: Long-Term Saccharomyces cerevisiae Preservation for a Deep Space Biosensor Mission
Santa Maria SR, Marina DB, Tieze S, Liddell LC, Bhattacharya S. BioSentinel: Long-Term Saccharomyces cerevisiae Preservation for a Deep Space Biosensor Mission. Astrobiology 2020, 23: 617-630. PMID: 31905002, PMCID: PMC10254977, DOI: 10.1089/ast.2019.2073.Peer-Reviewed Original Research