Featured Publications
Rest-activity rhythms predict time to hospitalizations and emergency department visits among participants in a randomized control of adults with heart failure and insomnia
Jeon S, Conley S, Hollenbeak C, O'Connell M, Wang Z, Tocchi C, Redeker N. Rest-activity rhythms predict time to hospitalizations and emergency department visits among participants in a randomized control of adults with heart failure and insomnia. Sleep Medicine 2023, 108: 1-7. PMID: 37301192, PMCID: PMC10336725, DOI: 10.1016/j.sleep.2023.05.019.Peer-Reviewed Original ResearchConceptsRest-activity rhythmED visitsHeart failureEmergency departmentCircadian quotientEarly hospitalizationWrist actigraphyEarly ED visitsChronic heart failureLow ejection fractionFirst cardiac eventCox proportional hazardsEffects of insomniaCognitive behavioral therapyComposite eventsNYHA classHF patientsCardiac eventsCPAP useSevere painEjection fractionMale sexSevere insomniaHospitalizationInsomnia severityTrajectory of self-care in people with stable heart failure and insomnia after two self-care interventions
Conley S, Jeon S, Andrews L, Breazeale S, Hwang Y, O'Connell M, Linsky S, Redeker N. Trajectory of self-care in people with stable heart failure and insomnia after two self-care interventions. Patient Education And Counseling 2022, 105: 3487-3493. PMID: 36088189, DOI: 10.1016/j.pec.2022.09.001.Peer-Reviewed Original ResearchConceptsStable heart failureSelf-care interventionsHeart failureSevere baseline fatigueSelf-care supportSelf-care educationSelf-care groupEffects of CBTCognitive behavioral therapyGroup-based trajectory modelingBaseline fatigueEfficacious interventionsHealthcare providersSecondary analysisInsomniaBehavioral therapySelf-CareChi-squareDemographic characteristicsInterventionT-testFunctional performanceAdultsTrajectory modelingFailureCognitive behavioral therapy for insomnia has sustained effects on insomnia, fatigue, and function among people with chronic heart failure and insomnia: the HeartSleep Study
Redeker NS, Yaggi HK, Jacoby D, Hollenbeak CS, Breazeale S, Conley S, Hwang Y, Iennaco J, Linsky S, Nwanaji-Enwerem U, O’Connell M, Jeon S. Cognitive behavioral therapy for insomnia has sustained effects on insomnia, fatigue, and function among people with chronic heart failure and insomnia: the HeartSleep Study. Sleep 2021, 45: zsab252. PMID: 34657160, PMCID: PMC8754495, DOI: 10.1093/sleep/zsab252.Peer-Reviewed Original ResearchConceptsChronic heart failureSix-minute walk distanceStable heart failureHeart failureInsomnia severityWalk distanceSleep characteristicsSelf-reported sleep latencyGeneral linear mixed modelSelf-reported sleep characteristicsMonths of treatmentSelf-management educationSelf-management programSleep hygiene educationCognitive behavioral therapyEjection fractionPrimary outcomeDaytime symptomsExcessive daytimePhysical functionDaytime sleepinessSleep latencyMild insomniaSleep qualitySleep efficiencyLatent Transition Analysis of the Symptom Experience of Cancer Patients Undergoing Chemotherapy
Jeon S, Sikorskii A, Given BA, Given CW, Redeker NS. Latent Transition Analysis of the Symptom Experience of Cancer Patients Undergoing Chemotherapy. Nursing Research 2019, 68: 91-98. PMID: 30540701, PMCID: PMC6399048, DOI: 10.1097/nnr.0000000000000332.Peer-Reviewed Original ResearchConceptsSymptom experienceCancer patientsYoung adultsEmotional role functioningTreatment-related symptomsClass A patientsBetter physical functionAdult cancer patientsGeneral health perceptionRandomized clinical trialsClustering of symptomsPatients' symptom experiencesSymptom management interventionsLatent transition analysisNumber of symptomsQuality of lifeLess comorbidityA patientsSymptom managementPhysical functionClinical trialsHealth perceptionMultiple symptomsRole functioningPatients' membership
2021
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study
Xiao C, Beitler JJ, Peng G, Levine ME, Conneely KN, Zhao H, Felger JC, Wommack EC, Chico CE, Jeon S, Higgins KA, Shin DM, Saba NF, Burtness BA, Bruner DW, Miller AH. Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study. Cancer 2021, 127: 3361-3371. PMID: 34027995, DOI: 10.1002/cncr.33641.Peer-Reviewed Original ResearchConceptsC-reactive proteinIL-6 levelsEpigenetic age accelerationNeck cancerInterleukin-6Inflammatory markersHigher epigenetic age accelerationLower C-reactive proteinAge accelerationHigher C-reactive proteinMultidimensional Fatigue Inventory-20Poor functional outcomeBlood DNA methylationMonths postradiotherapyAdvanced diseaseConcurrent chemoradiationMost patientsDistant metastasisFunctional outcomeSevere fatigueTreatment completionRadiation therapyPatientsGreater fatigueInflammation
2020
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Xiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.Peer-Reviewed Original ResearchConceptsCancer-related fatigueGut microbiomePilot studyHigh-fatigue groupLow-fatigue groupsGut-brain axisMultidimensional Fatigue InventoryGut microbiota patternBrain healthCancer patientsFatigue InventoryNeck cancerPurposeRecent evidenceStool samplesImmune responseMicrobiota patternsGut microbiotaInflammationOne monthBrain functionPatientsConclusionsOur resultsFatty acid synthesisEPIC BeadChipDNA methylation changesPilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes
Xiao C, Beitler JJ, Higgins KA, Chico CE, Withycombe JS, Zhu Y, Zhao H, Lin IH, Li F, Jeon S, Irwin M, Bruner DW, Miller AH, Gary R. Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes. Brain Behavior And Immunity 2020, 88: 184-192. PMID: 32330594, PMCID: PMC7415514, DOI: 10.1016/j.bbi.2020.04.044.Peer-Reviewed Original ResearchConceptsExercise groupInflammatory markersChair standNeck cancerBiceps curlSoluble TNF receptor IIMultidimensional Fatigue Inventory-20Tumor necrosis factor αPilot studyResistance exercise interventionTNF receptor IIPlasma interleukin-6Anti-inflammatory effectsC-reactive proteinPhysical function measuresIL1 receptor antagonistHand grip strengthNecrosis factor αIntensity-modulated radiotherapyStandard careExercise interventionWalk distanceRadiotherapy regimenHNC patientsMean age
2019
Daytime and Nighttime Sleep Characteristics and Pain Among Adults With Stable Heart Failure.
Conley S, Feder SL, Jeon S, Redeker NS. Daytime and Nighttime Sleep Characteristics and Pain Among Adults With Stable Heart Failure. The Journal Of Cardiovascular Nursing 2019, 34: 390-398. PMID: 31365442, PMCID: PMC6690780, DOI: 10.1097/jcn.0000000000000593.Peer-Reviewed Original ResearchConceptsPoor sleep qualityHeart failureSleep medicationSleep characteristicsDaytime sleepinessSleep qualitySleep durationSelf-reported poor sleep qualityPittsburgh Sleep Quality IndexMore sleep medicationsStable heart failureBodily pain scaleSleep Quality IndexCross-sectional studyPresence of insomniaLong sleep durationNighttime sleep characteristicsSpecific sleep characteristicsSleep Habits QuestionnaireNocturnal sleep characteristicsPain scaleSymptom burdenMore painSleep disturbancesInsomnia symptomsEndocrine Therapy–Related Symptoms and Quality of Life in Female Cancer Survivors in the Yale Fitness Intervention Trial
Park S, Knobf M, Jeon S. Endocrine Therapy–Related Symptoms and Quality of Life in Female Cancer Survivors in the Yale Fitness Intervention Trial. Journal Of Nursing Scholarship 2019, 51: 317-325. PMID: 30874369, DOI: 10.1111/jnu.12471.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsQuality of lifeTherapy-related symptomsExercise intervention groupAromatase inhibitorsEndocrine therapyCancer survivorsExercise interventionIntervention groupBreast Cancer Prevention Trial Symptom ChecklistFunctional assessmentControl groupCancer Therapy-Endocrine SubscalePrevious large clinical trialsEndocrine therapy groupMild symptom distressCancer Therapy-GeneralExercise control groupLarge clinical trialsAdjuvant chemotherapyAdjuvant therapyHormonal therapyExercise groupIntervention trialsWeight management
2018
Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease
Conley S, Jeon S, Proctor DD, Sandler RS, Redeker NS. Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease. Journal Of Nursing Scholarship 2018, 50: 473-481. PMID: 29971936, PMCID: PMC6120775, DOI: 10.1111/jnu.12409.Peer-Reviewed Original ResearchConceptsSymptom cluster membershipInflammatory bowel diseaseSymptom burdenBowel diseaseLower symptom burdenPsychological symptoms groupSymptom management optionsHigh symptom burdenRetrospective longitudinal studyLatent transition analysisActive diseaseClinical factorsPain interferenceColitis FoundationSleep disturbancesCluster membershipHigh burdenMultiple symptomsSymptom groupsPhysical symptomsPsychological symptomsLow burdenSymptom clustersLongitudinal changesSymptoms
2004
Effect of a Cognitive Behavioral Intervention on Reducing Symptom Severity During Chemotherapy
Given C, Given B, Rahbar M, Jeon S, McCorkle R, Cimprich B, Galecki A, Kozachik S, Brady A, Fisher-Malloy MJ, Courtney K, Bowie E. Effect of a Cognitive Behavioral Intervention on Reducing Symptom Severity During Chemotherapy. Journal Of Clinical Oncology 2004, 22: 507-516. PMID: 14752074, DOI: 10.1200/jco.2004.01.241.Peer-Reviewed Original ResearchConceptsSupportive care medicationsCognitive-behavioral interventionsSymptom severitySupportive medicationsCare medicationsConventional careBehavioral interventionsExperimental interventionCommunity cancer centerProportion of patientsSymptom Severity IndexBaseline symptom severityStage of cancerHigher symptom severityExperimental groupPrimary outcomeChemotherapy protocolsCancer CenterSeverity scoreMedical recordsTreatment statusPatientsMedicationsSolid tumorsChemotherapy