2024
The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume
2023
A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists
Beddok A, Lim R, Thariat J, Shih H, Fakhri G. A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists. Cancers 2023, 15: 4906. PMID: 37894273, PMCID: PMC10605284, DOI: 10.3390/cancers15204906.Peer-Reviewed Original ResearchProton therapyRadiation therapyRadiation oncologistsIntensity-modulated proton therapyNon-oncologistsNon-radiation oncologistsImage-guided RTFollow-upExternal beam therapyArc therapyThree-dimensional conformal RTCT simulationPatient alignmentTarget volumeIntensity-modulated RTRT planningCompletion of RTPotential late effects of treatmentMedical physicistsLifelong follow-upLate effects of treatmentPatient follow-upBeam therapyNon-radiativeOptimize treatment outcomes
2022
Automation of generative adversarial network-based synthetic data-augmentation for maximizing the diagnostic performance with paranasal imaging
Kong H, Kim J, Moon H, Park H, Kim J, Lim R, Woo J, Fakhri G, Kim D, Kim S. Automation of generative adversarial network-based synthetic data-augmentation for maximizing the diagnostic performance with paranasal imaging. Scientific Reports 2022, 12: 18118. PMID: 36302815, PMCID: PMC9613909, DOI: 10.1038/s41598-022-22222-z.Peer-Reviewed Original ResearchConceptsSynthetic data augmentationData augmentationLack of training dataConventional data augmentationDeep learning methodsTraining dataLearning methodsPipeline approachAlgorithm trainingGraphical dataAutomationWaters' view radiographsModel performanceAutomated pipelinePerformancePerformance parametersAlgorithmDatasetAugmentationDataMethodPipelineRulesIndustrial workersHuman biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal modelsACT: Semi-supervised Domain-Adaptive Medical Image Segmentation with Asymmetric Co-training
Liu X, Xing F, Shusharina N, Lim R, Jay Kuo C, El Fakhri G, Woo J. ACT: Semi-supervised Domain-Adaptive Medical Image Segmentation with Asymmetric Co-training. Lecture Notes In Computer Science 2022, 13435: 66-76. PMID: 36780245, PMCID: PMC9911133, DOI: 10.1007/978-3-031-16443-9_7.Peer-Reviewed Original ResearchSemi-supervised domain adaptationUnsupervised domain adaptationSemi-supervised learningMedical image segmentationDomain adaptationDomain shiftLabel supervisionTarget domainImage segmentationDomain dataLeverage different knowledgePseudo-label noiseSignificant domain shiftSupervised joint trainingLabeled source domainUnlabeled target dataUnlabeled target domainLabeled target samplesTarget domain dataSource domain dataState-of-the-artMRI segmentation taskSubstantial performance gainsPseudo-labelsLabel noiseJoint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Piccardo A, Albert N, Borgwardt L, Fahey F, Hargrave D, Galldiks N, Jehanno N, Kurch L, Law I, Lim R, Lopci E, Marner L, Morana G, Young Poussaint T, Seghers V, Shulkin B, Warren K, Traub-Weidinger T, Zucchetta P. Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3852-3869. PMID: 35536420, PMCID: PMC9399211, DOI: 10.1007/s00259-022-05817-6.Peer-Reviewed Original ResearchConceptsAmino acid positron emission tomographyPositron emission tomographyPaediatric neuro-oncologyEuropean Society for Paediatric Oncology (SIOPENeuro-oncologyLevel of evidenceBrain tumor groupPositron emission tomography imagingEvidence-based recommendationsPaediatric patientsTumor groupResponse assessmentClinician guidelinesPaediatric gliomasBrain gliomasImaging specialistsEmission tomographyRadiolabeled amino acidsConsensus opinionEANMPaediatric oncologyPET radiopharmaceuticalsGliomaNuclear medicineOncologySNMMI procedure standard/EANM practice guideline on pediatric [99mTc]Tc-DMSA renal cortical scintigraphy: an update
Vali R, Armstrong I, Bar-Sever Z, Biassoni L, Borgwardt L, Brown J, Grant F, Mandell G, Majd M, Nadel H, Ng T, Roca-Bielsa I, Rohringer T, Santos A, Seghers V, Shaikh N, Ted Treves S, Zaffino-Nevrotski T, Zucchetta P, Lim R. SNMMI procedure standard/EANM practice guideline on pediatric [99mTc]Tc-DMSA renal cortical scintigraphy: an update. Clinical And Translational Imaging 2022, 10: 173-184. DOI: 10.1007/s40336-022-00484-x.Peer-Reviewed Original ResearchEuropean Association of Nuclear MedicineRenal cortical scintigraphyCortical scintigraphyStandard of careImprove patient careEvidence-based recommendationsProfessional medical associationsLevel of trainingLevel of evidenceMedicine careTechnology subsequent to publicationPatient careLegal standard of careMedicine physiciansNuclear medicineMedicine practicePractice guidelinesDiagnostic nuclear medicine imagingCareComplexity of human conditionsExpert consensusMedical professionalsNuclear medicine physiciansPractice medicineMedical AssociationThe role of renal contour change in the diagnosis of cortical scarring after urinary tract infection.
Muniz G, Charron M, Lim R, Shammas A, Liu H, Shaikh N. The role of renal contour change in the diagnosis of cortical scarring after urinary tract infection. Am J Nucl Med Mol Imaging 2022, 12: 41-43. PMID: 35295886, PMCID: PMC8918400.Peer-Reviewed Original ResearchUrinary tract infectionRenal scarringTract infectionsRenal contourDiagnosis of renal scarringPermanent renal scarringProspective clinical trialFollow-up scansNuclear medicine physiciansTechnetium-99mPresence of abnormalitiesRIVUR studyContour abnormalitiesCortical scarringClinical trialsTechnetium-99Medicine physiciansGold standardEligibility criteriaScarsContour changesAbnormalitiesDiagnosisInfectionChildren
2021
Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas
Marin T, Zhuo Y, Lahoud R, Tian F, Ma X, Xing F, Moteabbed M, Liu X, Grogg K, Shusharina N, Woo J, Lim R, Ma C, Chen Y, El Fakhri G. Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas. Radiotherapy And Oncology 2021, 167: 269-276. PMID: 34808228, PMCID: PMC8934266, DOI: 10.1016/j.radonc.2021.09.034.Peer-Reviewed Original ResearchConceptsGross tumor volumeRadiation therapy treatment planningGross tumor volume contoursGross tumor volume delineationTherapy treatment planningIntra-observer variabilityConsensus contoursGTV contoursPre-operative CT imagesSoft tissue sarcomasRadiation oncologistsTumor volumeBone sarcomasTreatment planningAccurate contoursCT imagesDelineation procedureSarcomaSoft tissueConfidence levelRadiationPatientsHausdorff distanceMultiple contoursX-rayDetecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians
Petibon Y, Fahey F, Cao X, Levin Z, Sexton‐Stallone B, Falone A, Zukotynski K, Kwatra N, Lim R, Bar‐Sever Z, Chemli Y, Treves S, Fakhri G, Ouyang J. Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians. Medical Physics 2021, 48: 4249-4261. PMID: 34101855, DOI: 10.1002/mp.15033.Peer-Reviewed Original ResearchConceptsSingle-photon emission computed tomographyLow back painLumbar lesionsPediatric patientsTc-MDPEvaluate low back painCause of low back painTc-MDP scanLesion-presentEmission computed tomographyConvolutional neural networkClinical likelihoodBack painInterreader variabilityDeep convolutional neural networkLumbar locationLesionsStress lesionsFocal lesionsDeep learningPatientsLumbar stressPhysiciansDL systemsLROC studiesValidation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH)
Lim R, Shailam R, Hulett R, Skrinar A, Nixon A, Williams A, Nixon M, Thacher T. Validation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH). Bone 2021, 148: 115964. PMID: 33878504, DOI: 10.1016/j.bone.2021.115964.Peer-Reviewed Original ResearchConceptsRickets Severity ScaleInter-rater reliabilityGlobal Impression of ChangeX-linked hypophosphatemiaIntra-raterImpression of ChangeRadiographic Global Impression of ChangeGlobal scoreRGI-CModerate to almost perfect agreementStandardized response meanIntra-rater reliabilityAlmost perfect agreementWeighted kappa valuesResponse meanChange scoresStanding heightBaseline to weekLeg scoreHealing of ricketsSeverity ScalePerfect agreementRickets severityBurosumab treatmentKappa values
2020
Dietl crisis: Presentation and imaging findings in a 7-year-old boy
Lahoud R, Esker W, Thurston S, Kohanski M, Elder J, Lim R. Dietl crisis: Presentation and imaging findings in a 7-year-old boy. Radiology Case Reports 2020, 16: 555-559. PMID: 33384756, PMCID: PMC7772522, DOI: 10.1016/j.radcr.2020.12.048.Peer-Reviewed Original ResearchMagnetic resonance urographySevere left hydronephrosisDietl's crisisLeft hydronephrosisTime-to-peak enhancementIntermittent ureteropelvic junction obstructionUreteropelvic junction obstructionFollow-up USColicky abdominal painAberrant blood vesselsSurgical pyeloplastySymptomatic resolutionAbdominal painRare entityRecurrent episodesComplete resolutionImaging findingsRecurrent episodes of colicky abdominal painEmergency departmentHydronephrosisBlood vesselsUltrasoundMultiple visitsDiagnosisPublished literatureSNMMI Procedure Standard/EANM Practice Guideline on Pediatric 18F-FDG PET/CT for Oncology 1.0
Vali R, Alessio A, Balza R, Borgwardt L, Bar-Sever Z, Czachowski M, Jehanno N, Kurch L, Pandit-Taskar N, Parisi M, Piccardo A, Seghers V, Shulkin B, Zucchetta P, Lim R. SNMMI Procedure Standard/EANM Practice Guideline on Pediatric 18F-FDG PET/CT for Oncology 1.0. Journal Of Nuclear Medicine 2020, 62: 99-110. PMID: 33334912, PMCID: PMC8679588, DOI: 10.2967/jnumed.120.254110.Peer-Reviewed Original ResearchConceptsEuropean Association of Nuclear MedicineF-FDG PET/CTF-FDGComputerized tomographyTechnology subsequent to publicationEvidence-based recommendationsLevel of trainingNuclear medicineLevel of evidenceDiagnostic nuclear medicine imagingPractice of medicineComplexity of human conditionsMedicine careStandard of careScience of nuclear medicineLegal standard of careCourse of actionMedicine practiceConsensus processPractice guidelinesSociety of Nuclear MedicinePediatric oncologyMedical professionalsClinician guidelinesApplications of nuclear medicineCorticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial
Shaikh N, Shope T, Hoberman A, Muniz G, Bhatnagar S, Nowalk A, Hickey R, Michaels M, Kearney D, Rockette H, Charron M, Lim R, Majd M, Shalaby-Rana E, Kurs-Lasky M, Cohen D, Wald E, Lockhart G, Pohl H, Martin J. Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Pediatric Nephrology 2020, 35: 2113-2120. PMID: 32556960, PMCID: PMC7529851, DOI: 10.1007/s00467-020-04622-3.Peer-Reviewed Original ResearchConceptsFebrile urinary tract infectionUrinary tract infectionAdjuvant systemic corticosteroidsKidney scarringSystemic corticosteroidsTract infectionsInitiate urinary tract infectionReducing kidney scarringEfficacy of corticosteroidsMethodsChildren aged 2Absolute risk reductionRandomized to corticosteroidsMonths to 6Statistically significant differencePlacebo groupAdjuvant corticosteroidsCorticosteroidsKidney scansPlaceboSignificant differenceAged 2ScarsKidneyInfectionMonthsReducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults.
Tabari A, Gee M, Singh R, Lim R, Nimkin K, Primak A, Schmidt B, Kalra M. Reducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults. American Journal Of Roentgenology 2020, 214: 1199-1205. PMID: 32286868, DOI: 10.2214/ajr.19.22231.Peer-Reviewed Original ResearchConceptsSingle-energy CTContrast material volumeDS-DECTDual-energy CTRadiation doseThird-generation dual-source CT scannerDual-source dual-energy CTDual-source CT scannerContrast volume reductionCT dose descriptorsMean patient ageApplications of dual-energy CTContrast medium volumeWeight-matched patientsYoung adultsReduce radiation doseLow radiation doseCohen's kappa testConsecutive childrenPatient ageRadiological findingsDose descriptorsPatient demographicsRetrospective studyKappa test18 F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis of suspected paraneoplastic syndromes: A retrospective analysis
Bresler R, Schroeder H, Chow D, Lim R. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis of suspected paraneoplastic syndromes: A retrospective analysis. World Journal Of Nuclear Medicine 2020, 19: 124-130. PMID: 32939199, PMCID: PMC7478297, DOI: 10.4103/wjnm.wjnm_48_19.Peer-Reviewed Original ResearchF-FDG PET/CTSuspected paraneoplastic syndromeNegative predictive valueParaneoplastic syndromeF-FDGF-fluorodeoxyglucose positron emission tomography/computed tomographyWhole-body <sup>18</sup>F-FDG PET/CTClinical presentation of tumorsPositron emission tomography/computed tomographySingle-center retrospective studyPredictive valueEmission tomography/computed tomographyPresentation of tumorsFollow-up timeElectronic chart reviewPositive predictive valueFollow-up periodSigns and symptomsAncillary diagnostic proceduresDiagnostic imaging toolTomography/computed tomographyF-fluorodeoxyglucoseClinical presentationDiagnostic challengeRetrospective study
2019
Development and validation of image quality scoring criteria (IQSC) for pediatric CT: a preliminary study
Padole A, Sagar P, Westra S, Lim R, Nimkin K, Kalra M, Gee M, Rehani M. Development and validation of image quality scoring criteria (IQSC) for pediatric CT: a preliminary study. Insights Into Imaging 2019, 10: 95. PMID: 31549234, PMCID: PMC6757090, DOI: 10.1186/s13244-019-0769-8.Peer-Reviewed Original ResearchCT examsVentriculoperitoneal (VP) shuntBoard-certified pediatric radiologistsMedian image quality scorePediatric CT examinationsPediatric CT examsAdequate image qualityImage quality scoresRoutine abdomenRoutine chestPediatric CTScoring criteriaCT examinationsPediatric radiologistsInterobserver agreementInterobserver variabilityAssessment of image qualityImage qualityKidney stonesVentriculoperitonealScoring scaleRadiologistsScoresExamQuality scoresIs Availability of 99mTc-DMSA Insufficient to Meet Clinical Needs in the United States? A Survey.
Lim R, Bar-Sever Z, Treves S. Is Availability of 99mTc-DMSA Insufficient to Meet Clinical Needs in the United States? A Survey. Journal Of Nuclear Medicine 2019, 60: 14n-16n. PMID: 31371622.Peer-Reviewed Original ResearchPET/MR Imaging: Current Updates on Pediatric Applications
Kwatra N, Lim R, Gee M, States L, Vossough A, Lee E. PET/MR Imaging: Current Updates on Pediatric Applications. Magnetic Resonance Imaging Clinics Of North America 2019, 27: 387-407. PMID: 30910104, DOI: 10.1016/j.mric.2019.01.012.Peer-Reviewed Original ResearchClinical significance of incidentally discovered renal cysts in pediatric patients
Botwin A, Phewplung T, Wu K, Lim R, Traum A, Gee M. Clinical significance of incidentally discovered renal cysts in pediatric patients. Abdominal Radiology 2019, 44: 2835-2840. PMID: 30972430, DOI: 10.1007/s00261-019-02017-z.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePediatric patientsRenal cystsFamily historyClinical significanceCyst groupRisk of autosomal dominant polycystic kidney diseaseDiagnosis of autosomal dominant polycystic kidney diseaseAssociated with higher incidenceMethodsA retrospective searchFollow-up imagingDominant polycystic kidney diseaseSearch of radiology reportsMaximum cyst diameterStatistically significant elevationPolycystic kidney diseaseNo malignancyRetrospective search of radiology reportsCyst evaluationBilateral cystsCyst sizeFollow-up studyCyst characteristicsCyst diameterImaging predictors