2022
Systemic ventricular strain is abnormal with elevated BMI in adults with congenital heart disease
Adlakha H, Malik P, Donthula R, Rajagopal H, Kan A, Srivastava S, Karnik R, Shenoy R. Systemic ventricular strain is abnormal with elevated BMI in adults with congenital heart disease. Progress In Pediatric Cardiology 2022, 65: 101467. DOI: 10.1016/j.ppedcard.2021.101467.Peer-Reviewed Original ResearchElevated body mass indexBody mass indexCongenital heart diseaseType of CHDTransthoracic echocardiogramEjection fractionACHD patientsCardiac dysfunctionHeart diseaseCircumferential strainSignificant associationLV end-diastolic volumeSubclinical cardiac changesSubclinical myocardial dysfunctionSubset of patientsLeft ventricular hypertrophyMultivariate logistic regressionEnd-diastolic volumeResults Univariate analysisWilcoxon rank sum testRank sum testMedian GCSLifestyle modificationEchocardiographic markersBackground Obesity
2014
Anthracycline-related cardiotoxicity in childhood cancer survivors
Lipshultz SE, Karnik R, Sambatakos P, Franco VI, Ross SW, Miller TL. Anthracycline-related cardiotoxicity in childhood cancer survivors. Current Opinion In Cardiology 2014, 29: 103-112. PMID: 24284979, DOI: 10.1097/hco.0000000000000034.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnthracycline-related cardiotoxicityCardiovascular complicationsAnthracycline treatmentRisk factorsCardioprotective agentGrowth hormone replacement therapyPrevention of cardiotoxicityHormone replacement therapySerious cardiovascular complicationsChildhood cancer survivorsLong-term outcomesUse of biomarkersDosage of anthracyclinesCardiac transplantationCardiac dysfunctionCancer survivorsCardiac injuryClinical manifestationsReplacement therapyEarly recognitionChildhood cancerCardiotoxic effectsΒ-blockersEnzyme inhibitorsCardiotoxicity