2024
JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells
Wang L, Yukselten Y, Nuwagaba J, Sutton R. JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. Science Advances 2024, 10: eadl0368. PMID: 38507500, PMCID: PMC10954213, DOI: 10.1126/sciadv.adl0368.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsT cellsCCR5 expressionPrimary CD4<sup>+</sup> T cellsCD4+ T cellsHuman CD4+ T cellsHuman primary CD4<sup>+</sup> T cellsGlucocorticoid-regulated kinase 1HIV cure agendaHIV co-receptorsSignaling pathwayCCR5 levelsJAK/STAT inhibitor tofacitinibViremic patientsHIV patientsHIV infectionInhibitor tofacitinibJAK/STAT signaling pathwayCCR5Co-receptorHIVProtein levelsCCR2/CCR5Adverse effectsDown-regulation
2018
Identification and characterization of HIV positive Ethiopian elite controllers in both Africa and Israel
Kiros Y, Elinav H, Gebreyesus A, Gebremeskel H, Azar J, Chemtob D, Abreha H, Elbirt D, Shahar E, Chowers M, Turner D, Grossman Z, Haile A, Sutton R, Maayan S, Wolday D. Identification and characterization of HIV positive Ethiopian elite controllers in both Africa and Israel. HIV Medicine 2018, 20: 33-37. PMID: 30318718, PMCID: PMC6510948, DOI: 10.1111/hiv.12680.Peer-Reviewed Original ResearchConceptsStable CD4 countsElite controllersCD4 countAntiretroviral treatmentIsraeli cohortAfrican cohortART-naïve subjectsHIV elite controllersLarge African cohortHIV-positive patientsUndetectable viral loadCells/μLWarrants further investigationEthiopian patientsViral loadOverall prevalenceCohortPatientsPrevalenceFirst cohortUnique subgroupPossible environmental factorsSignificant differencesHomogenous populationSelection bias