2024
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Ghovanloo M, Effraim P, Tyagi S, Zhao P, Dib-Hajj S, Waxman S. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications Biology 2024, 7: 120. PMID: 38263462, PMCID: PMC10805714, DOI: 10.1038/s42003-024-05781-x.Peer-Reviewed Original ResearchConceptsDorsal root ganglionDorsal root ganglion neuronal excitabilityDorsal root ganglion neuronsNeuronal excitabilityCurrent-clamp analysisSteady-state inactivationVoltage-dependent sodiumSlow inactivated stateAutomated patch clamp platformMultielectrode array recordingsNav currentsNeuropathic painSodium currentRoot ganglionGanglion neuronsSlow inactivationInactivated stateCurrent inhibitorsIon channelsNeuronsInhibitory effectCannabinolArray recordingsEndocannabinoidCannabinoid
2020
Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels
Fouda MA, Ghovanloo M, Ruben PC. Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels. British Journal Of Pharmacology 2020, 177: 2932-2946. PMID: 32077098, PMCID: PMC7279989, DOI: 10.1111/bph.15020.Peer-Reviewed Original ResearchConceptsHigh glucoseOxidative stressHigh glucose-induced oxidative stressCardiac voltage-gated sodium channelGlucose-induced oxidative stressReactive oxygen speciesCardiac sodium channel isoformChannel inhibitory effectVoltage-gated sodium channelsSteady-state fast inactivationHigh glucose conditionsSodium channel isoformsAction potential modellingDeleterious effectsCardiovascular complicationsDiabetic patientsAction potentialsCell viability assaysArrhythmiasMajor causeInhibitory effectChannel isoformsCannabidiolGlucose conditionsSodium channels
2018
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. Journal Of Biological Chemistry 2018, 293: 16546-16558. PMID: 30219789, PMCID: PMC6204917, DOI: 10.1074/jbc.ra118.004929.Peer-Reviewed Original ResearchConceptsAnticonvulsant effectsVoltage-dependent sodium currentsPotassium channelsSafety of cannabidiolNav channelsCentral nervous system targetsEffects of cannabidiolNervous system targetsVoltage-dependent currentsVoltage-gated potassium channelsVoltage-clamp electrophysiologyAntiepileptic effectClinical efficacyCase reportAlters membrane fluidityIPSC-neuronsTherapeutic mechanismSodium currentHEK-293 cellsReceptor pathwayΔ9-tetrahydrocannabinolInhibitory effectCannabidiolChannel excitabilitySodium channels