2024
Rho-Kinase Is Differentially Expressed in the Adipose Tissue of Rodent and Human in Response to Aging, Sex, and Acute Exercise
Muñoz V, Vieira R, Katashima C, Gaspar R, Lino M, dos Santos Trombeta J, Duft R, Macêdo A, da Silva A, Ropelle E, de Moura L, Cintra D, Chacon-Mikahil M, Cavaglieri C, Pauli J. Rho-Kinase Is Differentially Expressed in the Adipose Tissue of Rodent and Human in Response to Aging, Sex, and Acute Exercise. The Journals Of Gerontology Series A 2024, 79: glae001. PMID: 38197701, DOI: 10.1093/gerona/glae001.Peer-Reviewed Original ResearchWhite adipose tissueAcute physical exerciseBrown adipose tissueAdipose tissueFemale rodentsInflammatory markersPhysical exerciseROCK activityInguinal white adipose tissueHuman white adipose tissueHigh-fat dietRho-kinasePossible therapeutic targetAcute exerciseAdipokine productionImpaired thermogenesisEndocrine functionMetabolism improvementTherapeutic targetAdipose depotsHuman preadipocytesROCK2 expressionMetabolic stressPreadipocyte differentiationCell senescence
2020
Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats
Muñoz V, Gaspar R, Esteca M, Baptista I, Vieira R, da Silva A, de Moura L, Cintra D, Ropelle E, Pauli J. Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats. Mechanisms Of Ageing And Development 2020, 186: 111213. PMID: 32032622, DOI: 10.1016/j.mad.2020.111213.Peer-Reviewed Original ResearchConceptsMiddle-aged ratsSoleus musclePhysical exerciseGlucose homeostasisAge-related metabolic disordersSkeletal muscle glucose uptakeSkeletal muscleImpaired glucose homeostasisType 2 diabetesMuscle glucose uptakeInsulin receptor substrate-1 phosphorylationWhole-body glucose homeostasisROCK activitySkeletal muscle fiber typesMuscle fiber typesInsulin resistanceSedentary ratsHigh insulinDifferent skeletal muscle fiber typesMetabolic disordersMetabolism-related genesPharmacological inhibitionRatsGlucose uptakeMuscle