2024
Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Osei J, Vaccarino V, Wang M, Shah A, Lampert R, Li L, Ko Y, Pearce B, Kutner M, Garcia E, Piccinelli M, Raggi P, Bremner J, Quyyumi A, Sun Y, Ahmed H, Haddad G, Daaboul O, Roberts T, Stefanos L, Correia L, Shah A. Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease. Circulation Cardiovascular Imaging 2024, 17: e016596. PMID: 38868952, PMCID: PMC11187646, DOI: 10.1161/circimaging.124.016596.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaLow heart rate variabilityAssociated with MSIMICoronary artery diseaseAssociated with higher oddsStable coronary artery diseaseStress-induced myocardial ischemiaAutonomic dysfunctionLow-frequency heart rate variabilityArtery diseaseHeart rate variabilityHigher oddsHigher heart rate variabilityResponse to stressIndicator of autonomic dysfunctionMyocardial ischemiaSpeech stressorAssociated with adverse cardiovascular outcomesMultivariate logistic regression modelAssociation of autonomic dysfunctionAdverse cardiovascular outcomesLogistic regression modelsBlack participantsHolter monitoringClinical factors
2005
Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators Results from the Triggers of Ventricular Arrhythmias (TOVA) study
Whang W, Albert CM, Sears SF, Lampert R, Conti JB, Wang PJ, Singh JP, Ruskin JN, Muller JE, Mittleman MA, Investigators T. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators Results from the Triggers of Ventricular Arrhythmias (TOVA) study. Journal Of The American College Of Cardiology 2005, 45: 1090-1095. PMID: 15808769, DOI: 10.1016/j.jacc.2004.12.053.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseVT/VFSymptoms of depressionVentricular arrhythmiasSevere depressionAnderson-Gill proportional hazards modelsArrhythmia studiesImplantable cardioverter defibrillator patientsEpidemiologic Studies Depression ScaleCardioverter-defibrillator patientsFatal ventricular arrhythmiasProportional hazards modelRisk of shockCAD patientsFirst shockAppropriate shocksArtery diseaseICD dischargesICD patientsRecurrent episodesMultiple confoundersElevated riskSevere symptomsDepression severityHazards model
2004
Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function
Vashist A, Arrighi J, Lampert R, Burg M, Soufer R. Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function. Journal Of Nuclear Cardiology 2004, 11: s21. DOI: 10.1016/j.nuclcard.2004.06.068.Peer-Reviewed Original ResearchChronic coronary artery diseaseRegional LV dysfunctionMyocardial ischemiaParasympathetic withdrawalLV dysfunctionChronic chronic coronary artery diseaseMental stress ischemiaRate-pressure productCoronary artery diseaseGreater parasympathetic withdrawalHigh-frequency powerStress ischemiaArtery diseaseNon-invasive imagingMPI defectsSympathovagal balanceIndividual patientsSPECT-MPIIschemiaMyocardial perfusionNoninvasive evaluationPatientsMental arithmetic taskAutonomic responsesSPECT defects