2023
Approaches to pandemic prevention – the chromatin vaccine
Zhang J, Askenase P, Jaenisch R, Crumpacker C. Approaches to pandemic prevention – the chromatin vaccine. Frontiers In Immunology 2023, 14: 1324084. PMID: 38143744, PMCID: PMC10739501, DOI: 10.3389/fimmu.2023.1324084.Peer-Reviewed Original ResearchConceptsEffective vaccineViral infectionCoronavirus diseaseImmunodeficiency syndromeHIV DNASuccessful vaccinePolio vaccineHIV integrationVaccineNext pandemicViral replicationIneffective vaccinesInfectionEpisomal formFuture pandemicsCurrent pandemicPandemic preventionPreventionPandemicEnd productsEpigenetic silencingSyndromeDiseaseHuman population
2007
c-Jun NH2-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection
Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection. Infection And Immunity 2007, 76: 308-316. PMID: 17998313, PMCID: PMC2223674, DOI: 10.1128/iai.00599-07.Peer-Reviewed Original ResearchConceptsIFN-gamma productionA. phagocytophilum infectionPhagocytophilum infectionIFN-gammaJnk2-null miceNatural killer T cellsA. phagocytophilumKiller T cellsIFN-gamma releaseIFN-gamma secretionGamma interferon productionT cell agonistsAnaplasma phagocytophilum infectionT cellsEarly eradicationGamma interferonInterferon productionInfectionC-Jun NH2-terminal kinase-2Inhibitory effectElevated levelsMiceAnaplasma phagocytophilumPhagocytophilumKinase 2