2018
Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial
D'Souza DC, Cortes-Briones J, Creatura G, Bluez G, Thurnauer H, Deaso E, Bielen K, Surti T, Radhakrishnan R, Gupta A, Gupta S, Cahill J, Sherif MA, Makriyannis A, Morgan PT, Ranganathan M, Skosnik PD. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The Lancet Psychiatry 2018, 6: 35-45. PMID: 30528676, DOI: 10.1016/s2215-0366(18)30427-9.Peer-Reviewed Original ResearchConceptsPF-04457845Cannabis withdrawal symptomsFatty acid amide hydrolaseCannabis withdrawalPlacebo groupAdverse eventsCannabis useWithdrawal symptomsFatty acid amide hydrolase inhibitorSerious adverse eventsPhase 2a trialWeeks of treatmentTreatment of cannabisCannabis use disorderSelf-reported cannabis useDSM-IV criteriaTreatment-related differencesTHC-COOH concentrationsAnandamide concentrationsTreat populationPrimary endpointPill countHospital admissionNovel FAAH inhibitorsSelf-reported cannabis
2011
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox HC, Anderson GM, Tuit K, Hansen J, Kimmerling A, Siedlarz KM, Morgan PT, Sinha R. Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings. Alcohol Clinical And Experimental Research 2011, 36: 351-360. PMID: 21919922, PMCID: PMC3243763, DOI: 10.1111/j.1530-0277.2011.01628.x.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcoholismAnxietyBlood PressureCuesDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodEmotionsFemaleHemodynamicsHumansHypothalamo-Hypophyseal SystemImaginationMalePituitary-Adrenal SystemPrazosinSecondary PreventionStress, PsychologicalConceptsCue-induced alcohol cravingNegative emotionsAlcohol-dependent individualsBlunted HPA responseAlcohol cravingAlcohol cuesStress dysregulationTreatment-seeking alcohol-dependent individualsCue-induced alcoholAlcohol cue exposureCue-Induced CravingImagery exposureBlood pressureHPA responseLower alcohol cravingCue exposureRelapse susceptibilityPreliminary efficacy studyEmotionsPrazosin groupPlacebo groupCravingCounterbalanced orderControl conditionAnxiety