2015
Integrating smoking cessation and alcohol use treatment in homeless populations: study protocol for a randomized controlled trial
Ojo-Fati O, John F, Thomas J, Joseph AM, Raymond NC, Cooney NL, Pratt R, Rogers CR, Everson-Rose SA, Luo X, Okuyemi KS. Integrating smoking cessation and alcohol use treatment in homeless populations: study protocol for a randomized controlled trial. Trials 2015, 16: 385. PMID: 26320081, PMCID: PMC4552980, DOI: 10.1186/s13063-015-0858-z.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeekly individual sessionsHomeless smokersIntensive smoking interventionAlcohol abuse treatmentSmoking cessation clinical trialCessation interventionsBehavioral therapyAlcohol outcomesCessation clinical trialIndividual sessionsSmoking outcomesAbuse treatmentAlcohol interventionsSmoking cessation interventionSmoking cessationSmoking ratesSmoking abstinenceAlcohol use treatmentSmoking interventionsIntensive smokingEvidence-based smoking cessation interventionsGroup sessionsUse treatmentCigarette smoking ratesConcurrent Alcohol and Tobacco Treatment: Effect on Daily Process Measures of Alcohol Relapse Risk
Cooney NL, Litt MD, Sevarino KA, Levy L, Kranitz LS, Sackler H, Cooney JL. Concurrent Alcohol and Tobacco Treatment: Effect on Daily Process Measures of Alcohol Relapse Risk. Journal Of Consulting And Clinical Psychology 2015, 83: 346-358. PMID: 25622198, PMCID: PMC4380705, DOI: 10.1037/a0038633.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionSmoking treatmentCessation interventionsSmoking abstinenceProcess measuresAlcohol treatmentOutpatient alcohol treatment programAlcohol-dependent smokersDaily smoking abstinenceAlcohol relapse riskOutpatient alcohol treatmentLow alcohol consumptionAlcohol treatment programsDependent smokersRelapse riskAlcohol abstinenceWaiting listInteractive voice response systemSmoking outcomesAlcohol consumptionCSC participantsVoice response systemIVR assessmentsTreatment programDaily assessment
2012
Prospective Analysis of Early Lapse to Drinking and Smoking Among Individuals in Concurrent Alcohol and Tobacco Treatment
Holt LJ, Litt MD, Cooney NL. Prospective Analysis of Early Lapse to Drinking and Smoking Among Individuals in Concurrent Alcohol and Tobacco Treatment. Psychology Of Addictive Behaviors 2012, 26: 561-572. PMID: 22023022, PMCID: PMC3336035, DOI: 10.1037/a0026039.Peer-Reviewed Original ResearchConceptsConcurrent alcoholPositive moodSmoking treatmentSmoking lapseLower positive moodEcological momentary assessment methodsOutpatient substance abuse clinicsMomentary assessment methodsQuantity/frequencyNegative affectLow confidenceEMA measuresAffective statesEMA ratingsHigher urgeTobacco treatmentSmoking urgesEarly lapseInitial lapseSubstance abuse clinicsLapse riskNicotine withdrawalBaseline measuresInitial smokingCurrent study
2009
Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum
Cooney NL, Cooney JL, Perry BL, Carbone M, Cohen EH, Steinberg HR, Pilkey DT, Sevarino K, Oncken CA, Litt MD. Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum. Addiction 2009, 104: 1588-1596. PMID: 19549054, PMCID: PMC2753831, DOI: 10.1111/j.1360-0443.2009.02624.x.Peer-Reviewed Original ResearchConceptsActive nicotine patchNicotine patchPlacebo gumNicotine gumSmoking cessationDouble-blind placebo-controlled clinical trialAlcohol treatmentPlacebo-controlled clinical trialBetter smoking outcomesCombination nicotine patchTransdermal nicotine patchDouble-blind conditionsSubstance abuse clinicsMonthly booster sessionsCombination nicotine replacementNicotine replacementCessation treatmentTobacco smokersLarge trialsCombination therapyMore cigarettesMedication conditionActive gumClinical trialsBooster sessions
2008
Dose-dependent reduction of hazardous alcohol use in a placebo-controlled trial of naltrexone for smoking cessation
O'Malley SS, Krishnan-Sarin S, McKee SA, Leeman RF, Cooney NL, Meandzija B, Wu R, Makuch RW. Dose-dependent reduction of hazardous alcohol use in a placebo-controlled trial of naltrexone for smoking cessation. The International Journal Of Neuropsychopharmacology 2008, 12: 589-597. PMID: 18796184, PMCID: PMC3094855, DOI: 10.1017/s146114570800936x.Peer-Reviewed Original ResearchConceptsHazardous drinkingSmoking cessationFavorable side effect profileDose-ranging clinical trialAlcohol useEffects of NTXPlacebo-controlled trialDose-ranging trialSide effect profileTransdermal nicotine patchOpiate antagonist naltrexoneDose-dependent reductionComponent of treatmentHazardous alcohol useOral NTXSecondary outcomesNicotine patchPrimary outcomeAntagonist naltrexoneCombination therapyClinical trialsBaseline predictorsOral preparationsHazardous drinkersNTX
2007
Concurrent Brief Versus Intensive Smoking Intervention During Alcohol Dependence Treatment
Cooney NL, Litt MD, Cooney JL, Pilkey DT, Steinberg HR, Oncken CA. Concurrent Brief Versus Intensive Smoking Intervention During Alcohol Dependence Treatment. Psychology Of Addictive Behaviors 2007, 21: 570-575. PMID: 18072840, PMCID: PMC2702144, DOI: 10.1037/0893-164x.21.4.570.Peer-Reviewed Original ResearchConceptsAlcohol-dependent smokersIntensive treatment groupTreatment groupsAbstinence ratesDependent smokersSmoking interventionsIntensive smoking cessation interventionIntensive smoking interventionNicotine patch therapySmoking cessation interventionOutpatient substance abuse treatment programsIntensive outpatient substance abuse treatment programSubstance abuse treatment programsCounseling sessionsAlcohol dependence treatmentBreath carbon monoxideQuit dateCessation interventionsPatch therapySmoking cessationDependence treatmentTobacco abstinenceSmoking treatmentTreatment assignmentTreatment programAlcohol and Tobacco Cessation in Alcohol-Dependent Smokers: Analysis of Real-Time Reports
Cooney NL, Litt MD, Cooney JL, Pilkey DT, Steinberg HR, Oncken CA. Alcohol and Tobacco Cessation in Alcohol-Dependent Smokers: Analysis of Real-Time Reports. Psychology Of Addictive Behaviors 2007, 21: 277-286. PMID: 17874878, PMCID: PMC2702146, DOI: 10.1037/0893-164x.21.3.277.Peer-Reviewed Original ResearchConceptsAlcohol-dependent smokersHigher urgeRelapse episodesLimited-strength modelCue-reactivity modelAlcohol-tobacco interactionsElectronic diary assessmentMultiple substance useCoping ModelRelapse precipitantsTobacco treatmentTobacco cessationAlcohol urgesSmoking episodesDiary assessmentsSmoking behaviorConcurrent alcoholSubstance useReal-time reportsED dataSmokersMoodEpisodesUrgeTreatment
2003
Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers
Cooney JL, Cooney NL, Pilkey DT, Kranzler HR, Oncken CA. Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers. Addiction 2003, 98: 913-921. PMID: 12814497, DOI: 10.1046/j.1360-0443.2003.00337.x.Peer-Reviewed Original ResearchConceptsNicotine deprivationSmoking urgesSelf-reported urgeAcute nicotine deprivationNon-deprived stateDay treatment programAlcohol-dependent smokersNeutral cuesMood inductionCue presentationCue exposureSubjects designTreatment programLaboratory sessionsUrgeRisk of relapseSessionsAlcoholic smokersSmoking cessationHeavy smokersAlcoholic patientsAcute effectsEarly recoverySmokersCuesCoping Skills and Treatment Outcomes in Cognitive-Behavioral and Interactional Group Therapy for Alcoholism
Litt MD, Kadden RM, Cooney NL, Kabela E. Coping Skills and Treatment Outcomes in Cognitive-Behavioral and Interactional Group Therapy for Alcoholism. Journal Of Consulting And Clinical Psychology 2003, 71: 118-128. PMID: 12602432, DOI: 10.1037/0022-006x.71.1.118.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentCoping skillsCoping skills trainingInteractional group therapySpecific treatment elementsCognitive behavioralBetter drinking outcomesGroup treatmentGroup therapyInterpersonal relationshipsDrinking outcomesTreatment elementsInteractional therapySkillsAlcohol-dependent menAlcohol dependenceSignificant predictorsDependent menTreatment outcomesTreatmentTherapyOutcomesGreater increaseTrainingDrinking
2002
In Vivo Assessment of the Effects of Smoking Cessation in Alcoholic Smokers
Cooney NL, Litt MD, Cooney JL. In Vivo Assessment of the Effects of Smoking Cessation in Alcoholic Smokers. Alcohol Clinical And Experimental Research 2002, 26: 1952-1953. PMID: 12500133, DOI: 10.1111/j.1530-0277.2002.tb02516.x.Peer-Reviewed Original ResearchScreening for health behaviors in ambulatory clinical settings Does smoking status predict hazardous drinking?
Kranzler HR, Amin H, Cooney NL, Cooney JL, Burleson JA, Petry N, Oncken C. Screening for health behaviors in ambulatory clinical settings Does smoking status predict hazardous drinking? Addictive Behaviors 2002, 27: 737-749. PMID: 12201381, DOI: 10.1016/s0306-4603(01)00206-4.Peer-Reviewed Original ResearchConceptsCurrent smoking statusSmoking statusFagerstrom Tolerance QuestionnaireHazardous drinkingCurrent smokersAlcohol consumptionCurrent alcohol consumptionAmbulatory clinical settingCurrent smokingPast smokersDental patientsMale genderYears of educationSmoking behaviorHealth behaviorsYounger ageMajority of studiesClinical settingScreening instrumentSmokersSmokingTolerance QuestionnairePast historySignificant predictorsDrinking
2001
Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients
Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.Peer-Reviewed Original ResearchConceptsCue-induced cravingAlcohol-dependent patientsTryptophan depletionAlcohol cue-induced cravingDouble-blind fashionPlasma free tryptophanAbstinent alcoholic patientsAmino acid drinkActive tryptophan depletionAlcoholic patientsSerotonin synthesisAcid drinkSober alcoholicsAlcoholic individualsPrecursor tryptophanCue exposurePatientsAlcohol useAbstinent alcoholic individualsCravingFree tryptophanAlcohol cuesTest dayGreater increaseSimilar drinksThe Role of Craving in Alcohol Use, Dependence, and Treatment
Flannery B, Roberts A, Cooney N, Swift R, Anton R, Rohsenow D. The Role of Craving in Alcohol Use, Dependence, and Treatment. Alcohol Clinical And Experimental Research 2001, 25: 299-308. PMID: 11236847, DOI: 10.1111/j.1530-0277.2001.tb02213.x.Peer-Reviewed Original Research
2000
Reactivity to alcohol‐related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics
Litt M, Cooney N, Morse P. Reactivity to alcohol‐related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics. Addiction 2000, 95: 889-900. PMID: 10946438, DOI: 10.1046/j.1360-0443.2000.9568896.x.Peer-Reviewed Original ResearchConceptsAlcohol-related stimuliSubstance abuse treatment programsGreater mood disturbancePredictors of alcoholGreater alcohol dependenceIntensive outpatient programAlcohol-dependent veteransHome environmentLater drinkingMood statesMood disturbanceCravingCorrelational designAnxiety scoresDrinking frequencyTreatment programHand-held computersLaboratory sessionsOutpatient programAlcohol dependenceLaboratory settingParticipantsRatingsUrgeModest correlation
1999
CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?
Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcohol Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.Peer-Reviewed Original ResearchConceptsAlcohol-dependent patientsHealthy controlsEndorphin levelsCSF levelsMonoamine metabolitesCSF measuresHealthy subjectsNorepinephrine metabolite MHPGLower CSF levelsBeta-endorphin levelsEarly-onset patientsCerebrospinal fluid levelsLate-onset patientsCentral neurotransmitter systemsCSF monoamine metabolitesDopamine metabolite HVAAlcohol cue exposureAlcohol-dependent individualsCue-Induced CravingAlcohol cue reactivityLumbar punctureMetabolite HVANeurotransmitter systemsMonoaminergic dysregulationMetabolite MHPG
1998
Compliance with Treatment and Follow‐up Protocols in Project MATCH: Predictors and Relationship to Outcome
Mattson M, Del Boca F, Carroll K, Cooney N, DiClemente C, Donovan D, Kadden R, McRee B, Rice C, Rycharik R, Zweben A. Compliance with Treatment and Follow‐up Protocols in Project MATCH: Predictors and Relationship to Outcome. Alcohol Clinical And Experimental Research 1998, 22: 1328-1339. PMID: 9756050, DOI: 10.1111/j.1530-0277.1998.tb03916.x.Peer-Reviewed Original ResearchConceptsStrongest baseline predictorsMultisite clinical trialProject MATCHClinicians/investigatorsPatient-treatment matchingTreatment complianceClinical trialsBaseline predictorsDrinking outcomesTherapy sessionsTreatment deliveryResearch protocolTreatment environmentFollowHigh rateTreatmentFuture studiesResearch followCompliancePredictorsAttendance dataPrevious studiesPatientsTherapyTrialsInternal Validity of Project MATCH Treatments: Discriminability and Integrity
Carroll K, Connors G, Cooney N, DiClemente C, Donovan D, Kadden R, Longabaugh R, Rounsaville B, Wirtz P, Zweben A. Internal Validity of Project MATCH Treatments: Discriminability and Integrity. Journal Of Consulting And Clinical Psychology 1998, 66: 290-303. PMID: 9583332, DOI: 10.1037/0022-006x.66.2.290.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapyCognitive-behavioral treatmentProject MATCHDay hospital treatmentPatient-treatment interactionsAlcoholics Anonymous (AA) involvementInternal validityStudy treatmentHospital treatmentIntensive treatmentTreatment doseAlcohol-dependent participantsIntensive inpatientAlcoholism treatmentEnhancement therapyNonspecific aspectsTherapeutic allianceTreatmentOutpatientsParticipantsManual guidelinesHigh levelsInpatientsTherapyAftercareDose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics
Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, Stetson P, Trevisan LA, Charney DS. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. JAMA Psychiatry 1998, 55: 354-360. PMID: 9554431, DOI: 10.1001/archpsyc.55.4.354.Peer-Reviewed Original ResearchEcological Momentary Assessment (EMA) With Treated Alcoholics: Methodological Problems and Potential Solutions
Litt M, Cooney N, Morse P. Ecological Momentary Assessment (EMA) With Treated Alcoholics: Methodological Problems and Potential Solutions. Health Psychology 1998, 17: 48-52. PMID: 9459069, DOI: 10.1037/0278-6133.17.1.48.Peer-Reviewed Original Research
1997
Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP)
Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.Peer-Reviewed Original ResearchConceptsHealthy subjectsAcoustic startle responseEthanol withdrawalStartle responseStartle magnitudeStartle amplitudeRandomized orderAcoustic startle magnitudeChronic alcoholic patientsSerotonin partial agonistDouble-blind conditionsAcoustic startle amplitudeNumber of episodesMale healthy subjectsΑ2-adrenergic antagonistTest dayMale patientsPlacebo dayAlcoholic patientsIntravenous infusionNoradrenergic functionYohimbine effectAlcohol detoxificationDrug infusionPreclinical studies