Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nature Communications 2017, 8: 1600. PMID: 29150604, PMCID: PMC5693957, DOI: 10.1038/s41467-017-01571-8.Peer-Reviewed Original ResearchConceptsPathogenic Th17 cellsTh17 cellsExperimental autoimmune encephalomyelitisMultiple sclerosisTh1/17 cellsPro-inflammatory TH17 cellsExpression of CXCR3Human autoimmune diseasesIL10 gene expressionEffect of treatmentMolecular signaturesBlood IFNAutoimmune encephalomyelitisAutoimmune diseasesHealthy controlsDistinct transcriptional profilesT cellsGene signatureReduced expressionHigh expressionTranscriptional signatureSignature genesSclerosisIL10IFN