2020
Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells
Hu D, Tjon E, Andersson K, Molica G, Pham M, Healy B, Murugaiyan G, Pochet N, Kuchroo V, Bokarewa M, Weiner H. Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30639-30648. PMID: 33203678, PMCID: PMC7720234, DOI: 10.1073/pnas.2007935117.Peer-Reviewed Original ResearchMeSH KeywordsAntirheumatic AgentsArthritis, RheumatoidBiomarkersCD4 AntigensCD4-Positive T-LymphocytesCytokinesGene ExpressionGene Expression ProfilingHumansInflammation MediatorsReceptors, CCR6Receptors, CXCR3RNA, Small InterferingSignal TransductionTh17 CellsTumor Necrosis Factor-alphaUpstream Stimulatory FactorsConceptsAnti-TNF therapyRefractory rheumatoid arthritisRheumatoid arthritisTh17 cellsT cellsProinflammatory cytokinesHigh-throughput gene expression analysisIL-17-producing Th17 cellsSignature genesDistinct gene expression profilesTranscription factor T-betProinflammatory cytokine IL-17ATranscription factor USF2Cytokines IL-17APathogenic Th17 cellsGene expression profilesGene expression analysisGranulocyte-macrophage colony-stimulating factorPotential therapeutic approachShort hairpin RNAColony-stimulating factorRA patientsIL-17ATh17 responsesExpression analysis
2017
Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nature Communications 2017, 8: 1600. PMID: 29150604, PMCID: PMC5693957, DOI: 10.1038/s41467-017-01571-8.Peer-Reviewed Original ResearchConceptsPathogenic Th17 cellsTh17 cellsExperimental autoimmune encephalomyelitisMultiple sclerosisTh1/17 cellsPro-inflammatory TH17 cellsExpression of CXCR3Human autoimmune diseasesIL10 gene expressionEffect of treatmentMolecular signaturesBlood IFNAutoimmune encephalomyelitisAutoimmune diseasesHealthy controlsDistinct transcriptional profilesT cellsGene signatureReduced expressionHigh expressionTranscriptional signatureSignature genesSclerosisIL10IFN