Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells
Hu D, Tjon E, Andersson K, Molica G, Pham M, Healy B, Murugaiyan G, Pochet N, Kuchroo V, Bokarewa M, Weiner H. Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30639-30648. PMID: 33203678, PMCID: PMC7720234, DOI: 10.1073/pnas.2007935117.Peer-Reviewed Original ResearchMeSH KeywordsAntirheumatic AgentsArthritis, RheumatoidBiomarkersCD4 AntigensCD4-Positive T-LymphocytesCytokinesGene ExpressionGene Expression ProfilingHumansInflammation MediatorsReceptors, CCR6Receptors, CXCR3RNA, Small InterferingSignal TransductionTh17 CellsTumor Necrosis Factor-alphaUpstream Stimulatory FactorsConceptsAnti-TNF therapyRefractory rheumatoid arthritisRheumatoid arthritisTh17 cellsT cellsProinflammatory cytokinesHigh-throughput gene expression analysisIL-17-producing Th17 cellsSignature genesDistinct gene expression profilesTranscription factor T-betProinflammatory cytokine IL-17ATranscription factor USF2Cytokines IL-17APathogenic Th17 cellsGene expression profilesGene expression analysisGranulocyte-macrophage colony-stimulating factorPotential therapeutic approachShort hairpin RNAColony-stimulating factorRA patientsIL-17ATh17 responsesExpression analysis