2024
Long-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, PMCID: PMC11413720, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskSelf-Change from Alcohol Problems among Racially and Ethnically Minoritized Adults: A Systematic Review
Haeny A, Schick M, Crouch M, Bautista T, Chowdhary A, McKenley C, Funaro M. Self-Change from Alcohol Problems among Racially and Ethnically Minoritized Adults: A Systematic Review. Current Addiction Reports 2024, 11: 818-837. DOI: 10.1007/s40429-024-00591-x.Peer-Reviewed Original ResearchSelf-changeAlcohol problemsProcess of self-changeREM groupRelevant constructsMultiracial groupsRacial identityFormal treatmentNative groupsNative HawaiiansLatin groupAlaska Native communitiesAlaska Native groupsREMPacific IslandersAlcoholNative communitiesAdultsSystematic reviewSystematic literature reviewHealing strategiesAntipsychotic agents in anxiety disorders: An umbrella review
Garakani A, Buono F, Salehi M, Funaro M, Klimowicz A, Sharma H, Faria C, Larkin K, Freire R. Antipsychotic agents in anxiety disorders: An umbrella review. Acta Psychiatrica Scandinavica 2024, 149: 295-312. PMID: 38382649, DOI: 10.1111/acps.13669.Peer-Reviewed Original ResearchSecond-generation antipsychoticsFirst-generation antipsychoticsGeneralized anxiety disorderStudies of antipsychoticsAnxiety disordersAntipsychotic agentsEfficacy of first-generation antipsychoticsTreatment of anxiety disordersEfficacy of antipsychotic agentsMeta-analysesAntidepressant treatmentNonantipsychotic medicationsAntipsychoticsFirst-line treatmentAnxietyComparing monotherapyUmbrella reviewDisordersQuetiapineSystematic reviewSide effectsAMSTAR-2Off-labelAPA PsycInfoCINAHL CompleteCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINE
2023
Outcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testA Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents
Aneni K, Meyer J, Funaro M, Pegram D, Umutoni F, Gomati de la Vega I, Jiao M, Fernandes C, Onyeaka H, Baiden P, Camenga D. A Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents. Current Addiction Reports 2023, 10: 378-395. DOI: 10.1007/s40429-023-00508-0.Peer-Reviewed Original ResearchSubstance useTobacco useLarge effect sizesSystematic reviewDigital interventionsEffect sizeSystematic literature searchBooster sessionsPrevention servicesPacific Islander groupsTrial studySignificant effect sizePrevent Substance UseMeta-AnalysisCannabis useLiterature searchAlcohol useEthnic distributionInterventionSignificant reductionAdolescentsMultiple sessionsEfficacyCannabisNative American adolescentsBiomarkers as prognostic determinants of epilepsy after post-acute central nervous system insults: a systematic review and meta-analysis (P3-5.017)
Misra S, Khan E, Lam T, Mazumder R, Eldem E, Gururangan K, Hickman L, Goswami V, Funaro M, Montaner J, Quinn T, Liebeskind D, Mishra N. Biomarkers as prognostic determinants of epilepsy after post-acute central nervous system insults: a systematic review and meta-analysis (P3-5.017). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203165.Peer-Reviewed Original ResearchMortality and functional outcomes in patients with post-stroke epileptic seizures: a systematic review and meta-analysis (S45.006)
Misra S, Vazquez J, Eldem E, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Yasuda C, Liebeskind D, Kasner S, Mishra N. Mortality and functional outcomes in patients with post-stroke epileptic seizures: a systematic review and meta-analysis (S45.006). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203419.Peer-Reviewed Original ResearchEvaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis
Aneni K, Gomati de la Vega I, Jiao M, Funaro M, Fiellin L. Evaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis. Progress In Brain Research 2023, 279: 1-36. PMID: 37661161, DOI: 10.1016/bs.pbr.2023.02.002.Peer-Reviewed Original Research
2022
Examining weight bias before and/or after bariatric surgery: A systematic review
Bennett BL, Lawson JL, Funaro MC, Ivezaj V. Examining weight bias before and/or after bariatric surgery: A systematic review. Obesity Reviews 2022, 23: e13500. PMID: 36053042, DOI: 10.1111/obr.13500.Peer-Reviewed Original ResearchConceptsBariatric surgeryWeight biasPeer-reviewed quantitative studiesRisk of biasBariatric populationMedical sequelaeHigh riskSurgeryBehavioral sequelaeSystematic reviewFuture patientsGreater riskWeight stigmaSequelaePatientsRiskSample of individualsPresent studyMost studiesNegative correlatesRigorous researchReviewStudyRacial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA
Jordan A, Quainoo S, Nich C, Babuscio TA, Funaro MC, Carroll KM. Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA. The Lancet Psychiatry 2022, 9: 660-675. PMID: 35752192, DOI: 10.1016/s2215-0366(22)00160-2.Peer-Reviewed Original ResearchConceptsSubstance use outcomesTreatment initiationJoanna Briggs Institute appraisal toolsSystematic reviewSubstance use disordersSignificant differencesSubstance use treatmentDissemination of treatmentUncontrolled trialsClinical trialsBaseline differencesStudy qualityInclusion criteriaUse disordersRCTsNarrative synthesisSocial determinantsUse treatmentAppraisal toolLatinx adultsEthnic differencesEthnic populationsOutcomesTrialsLatinx populationsEvidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review
Putta N, Hansen CE, Funaro MC, Campbell M, Essajee S, Mbori-Ngacha D, Frimpong S, Wang SY, Paintsil E. Evidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review. PLOS ONE 2022, 17: e0269063. PMID: 35709211, PMCID: PMC9202933, DOI: 10.1371/journal.pone.0269063.Peer-Reviewed Original ResearchConceptsSystematic reviewPrimary health care settingsService delivery interventionsMeta-analysis protocolPairs of reviewersHealth care providersEvidence-based service deliveryPreferred Reporting ItemsHealth care settingsRandom-effects modelComprehensive search strategyImmunologic outcomesPregnant womenCochrane LibraryTreatment optionsDelivery interventionsRetention of childrenInclusion criteriaCare settingsCare providersHIVRegistration numberReporting ItemsCare deliveryNarrative synthesisAn umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol
Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol. PLOS ONE 2022, 17: e0269772. PMID: 35709149, PMCID: PMC9202921, DOI: 10.1371/journal.pone.0269772.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsSerotonin-norepinephrine reuptake inhibitorsUse of antipsychoticsLong-term riskAnxiety disordersReuptake inhibitorsUmbrella reviewSide effectsPanic disorderSystematic reviewNon-antipsychotic medicationsUse of quetiapineFirst-line treatmentSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsEvidence of efficacyCommon psychiatric disordersTraditional pharmacologic treatmentTreatment of anxietyAdjunctive treatmentPharmacologic treatmentTricyclic antidepressantsAntipsychoticsPsychiatric disordersSocial anxiety disorderPrescription Stimulants and the Risk of Psychosis
Gallagher KE, Funaro MC, Woods SW. Prescription Stimulants and the Risk of Psychosis. Journal Of Clinical Psychopharmacology 2022, 42: 308-314. PMID: 35489031, DOI: 10.1097/jcp.0000000000001552.Peer-Reviewed Original ResearchConceptsObservational studySystematic reviewPsychosis riskCohort studyPrescription stimulantsRetrospective cohort studyProspective cohort studyCase-control studySelf-controlled case seriesInternational Prospective RegisterLongitudinal observational studyMeta-Analyses (PRISMA) guidelinesRisk of psychosisPreferred Reporting ItemsLarge-scale observational studyMPH exposureCase seriesTherapeutic dosesProspective RegisterBias assessmentEligible studiesPsychotic eventsLower riskPsychotic symptomsReporting Items
2021
Which Maturation Indicator is Most Accurate in Predicting Cessation of Facial Growth? A Systematic Review of the Literature
Reategui A, Phillips S, Khetpal S, Parsaei Y, Funaro M, Mukherjee T, Lopez J, Steinbacher DM. Which Maturation Indicator is Most Accurate in Predicting Cessation of Facial Growth? A Systematic Review of the Literature. Journal Of Craniofacial Surgery 2021, 33: 764-768. PMID: 34611106, DOI: 10.1097/scs.0000000000008253.Peer-Reviewed Original ResearchConceptsSystematic reviewJoanna Briggs Institute Critical Appraisal ChecklistQuality of evidenceMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsCritical Appraisal ChecklistGrowth maturationSkeletal maturity indicatorsCohort studyPediatric patientsSurgical timingProspective studySurgical interventionInclusion criteriaMenses onsetPaucity of articlesReporting ItemsAppraisal ChecklistSkeletal maturityPredictive indicatorSystematic searchGoogle ScholarLack of consensusFacial growthA systematic review of the association between sleep health and stress biomarkers in children
Ordway MR, Condon EM, Basile Ibrahim B, Abel EA, Funaro MC, Batten J, Sadler LS, Redeker NS. A systematic review of the association between sleep health and stress biomarkers in children. Sleep Medicine Reviews 2021, 59: 101494. PMID: 34098244, PMCID: PMC8458225, DOI: 10.1016/j.smrv.2021.101494.Peer-Reviewed Original ResearchConceptsSleep healthSystematic reviewStress biomarkersStress response systemEarly childhoodChildren ages 0Evidence of associationRole of sleepMetabolic outcomesSchool-aged childrenCurrent evidencePRISMA guidelinesNeuroendocrine variablesPhysiologic stressMajority of studiesSleep dimensionsSleepAges 0BiomarkersLongitudinal studyYoung childrenChildrenObjective measuresHealthAdult literatureA systematic review of ketamine for the treatment of depression among older adults
Farheen S, Gupta A, Dhar R, Patadia P, Funaro M, Bhattacharya G, Tampi R. A systematic review of ketamine for the treatment of depression among older adults. American Journal Of Geriatric Psychiatry 2021, 29: s93-s96. DOI: 10.1016/j.jagp.2021.01.089.Peer-Reviewed Educational MaterialsPrimary outcome measureUse of ketamineLate-life depressionTreatment of depressionOlder adultsElectroconvulsive therapyReceptor antagonistLife depressionOutcome measuresCurrent evidenceDepressive symptomsOlder subjectsHamilton Depression Rating Scale scoresN-methyl-D-aspartate receptor antagonistSystematic reviewStudy participantsDepression Rating Scale scoresAdverse effectsBenefits of ketamineTolerability of ketamineCognitive adverse effectsCochrane Central RegisterTreatment-resistant depressionAnti-depressant effectsRelapse of symptoms73936 Developing a Patient-Rated Outcome Measure of Alcohol and Drug Craving: A Systematic Review
Haeny A, Morean M, DeMartini K, Funaro M, O’Malley S. 73936 Developing a Patient-Rated Outcome Measure of Alcohol and Drug Craving: A Systematic Review. Journal Of Clinical And Translational Science 2021, 5: 39-39. PMCID: PMC8827664, DOI: 10.1017/cts.2021.505.Peer-Reviewed Original ResearchPatient-rated outcome measuresOutcome measuresSystematic reviewClinical trialsDrug useStimulant usePatient rated outcome measuresSubstance use disordersEffective treatmentPRISMA guidelinesUse disordersElectronic databasesDrug cravingPotential targetOpioidsCravingFDANicotineTrialsDisordersResults/CannabisReviewFindingsMedicationsIs there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults?
Gupta A, Joshi P, Bhattacharya G, Lehman M, Funaro M, Tampi DJ, Tampi RR. Is there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults? International Psychogeriatrics 2021, 34: 889-903. PMID: 33757611, DOI: 10.1017/s1041610221000235.Peer-Reviewed Educational MaterialsConceptsTreatment of deliriumTotal knee arthroplastyTotal hip arthroplastyPostoperative deliriumUse of anticonvulsantsPerioperative useSpinal surgeryOlder adultsElective total knee arthroplastyElective total hip arthroplastyUse of gabapentinCochrane Central RegisterAnalysis of RCTsPerioperative gabapentinCentral RegisterKnee arthroplastyHip arthroplastyDeliriumCurrent evidenceGabapentinRCTsAnticonvulsantsSystematic reviewArthroplastyComprehensive search