2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsTrends and predictors of Quality of Life in lung cancer survivors
Bade B, Zhao J, Li F, Tanoue L, Lazowski H, Alfano C, Silvestri G, Irwin M. Trends and predictors of Quality of Life in lung cancer survivors. Lung Cancer 2024, 191: 107793. PMID: 38640687, DOI: 10.1016/j.lungcan.2024.107793.Peer-Reviewed Original ResearchConceptsFunctional Assessment of Cancer Therapy - LungNon-small cell lung cancerHR-QOL scoresLung cancer survivorsHR-QOLAdvanced stage non-small cell lung cancerEarly-stage non-small cell lung cancerStage non-small cell lung cancerQuality of lifeCancer survivorsPhysical activityCell lung cancerEarly-stage diseasePredictors of quality of lifeHealth-related quality of lifeFollow-upHealth-related qualityHealthy weight maintenancePerformance statusAdvanced-stage non-small cell lung cancerLung cancerClinical significanceAssociated with older ageDiagnosed NSCLCTreatment-related side effects
2023
Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeath
2022
Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline
Ligibel JA, Bohlke K, May AM, Clinton SK, Demark-Wahnefried W, Gilchrist SC, Irwin ML, Late M, Mansfield S, Marshall TF, Meyerhardt JA, Thomson CA, Wood WA, Alfano CM. Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline. Journal Of Clinical Oncology 2022, 40: 2491-2507. PMID: 35576506, DOI: 10.1200/jco.22.00687.Peer-Reviewed Original ResearchConceptsWeight loss interventionCancer treatmentSystematic reviewNeutropenic dietPreoperative exerciseLoss interventionActive treatmentResistance exerciseLung cancerWeight managementActive cancer treatmentIntentional weight lossPatient-reported outcomesRisk of infectionQuality of lifeTypes of cancerCurative intentASCO guidelinesHospital stayPostoperative lengthTreatment toxicityOncology providersAdvanced cancerCochrane LibraryCardiorespiratory fitnessOral Cyanobacteria and Hepatocellular Carcinoma
Hernandez BY, Zhu X, Risch HA, Lu L, Ma X, Irwin ML, Lim JK, Taddei TH, Pawlish KS, Stroup AM, Brown R, Wang Z, Wong LL, Yu H. Oral Cyanobacteria and Hepatocellular Carcinoma. Cancer Epidemiology Biomarkers & Prevention 2022, 31: 221-229. PMID: 34697061, PMCID: PMC8755591, DOI: 10.1158/1055-9965.epi-21-0804.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusHepatocellular carcinomaRisk factorsLiver diseaseHCC casesOral microbiomeU.S. case-control studyIndependent risk factorChronic liver diseaseFatty liver diseaseHCC risk factorsGut microbial alterationsType 2 diabetesCase-control studyLiver cancer developmentNSAID useAspirin useC virusB virusHCC riskNegative historyOral samplesSignificant associationCancer development
2021
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage IPrediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. International Journal Of Cancer 2021, 149: 1067-1075. PMID: 33963766, PMCID: PMC8282739, DOI: 10.1002/ijc.33676.Peer-Reviewed Original ResearchConceptsOvarian cancer-specific mortalityCancer-specific mortalityNurses' Health StudyPhysical activityHazard ratioOvarian cancerHealth StudyWeek 1MET-hours/weekLow-grade serous tumorsLeisure-time physical activityPostdiagnosis physical activityRisk of deathEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsTime physical activityOvarian cancer diagnosisBetter prognosisSerous tumorsCancer survivalInverse associationLarge cohortDiagnosisCancer diagnosis
2020
Racial/Ethnic Disparities in Screening for and Awareness of High Cholesterol Among Pregnant Women Receiving Prenatal Care
Mszar R, Gopal DJ, Chowdary R, Smith CL, Dolin CD, Irwin ML, Soffer D, Nemiroff R, Lewey J. Racial/Ethnic Disparities in Screening for and Awareness of High Cholesterol Among Pregnant Women Receiving Prenatal Care. Journal Of The American Heart Association 2020, 10: e017415. PMID: 33345544, PMCID: PMC7955491, DOI: 10.1161/jaha.120.017415.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular disease risk factorsCardiovascular disease risk factorsNon-Hispanic black womenNon-Hispanic white womenDisease risk factorsPregnant womenObstetrician/gynecologistsPrenatal careLipid screeningRisk factorsHigh cholesterolYoung womenBackground Atherosclerotic cardiovascular diseaseTraditional cardiovascular risk factorsWhite womenCardiovascular risk factorsPreventive care servicesRacial/Ethnic DisparitiesAtherosclerotic cardiovascular diseaseRisk factor awarenessPrimary care physiciansEthnic disparities persistPennsylvania Health SystemBlack womenMaternal dyslipidemiaAssociation of relative dose intensity with BMI and pathologic complete response in patients treated with neoadjuvant chemotherapy for breast cancer
Usiskin I, Li F, Irwin ML, Cartmel B, Sanft T. Association of relative dose intensity with BMI and pathologic complete response in patients treated with neoadjuvant chemotherapy for breast cancer. Breast Cancer Research And Treatment 2020, 186: 191-197. PMID: 33125620, DOI: 10.1007/s10549-020-05994-8.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseNeoadjuvant chemotherapyBreast cancerDose reductionDose intensityComplete responseLower BMIHigh relative dose intensityDose delaysTreatment tolerabilityPatient adherenceTreatment delayTumor characteristicsCancer HospitalChemotherapy dosesHigher BMIRetrospective studyResultsOur cohortMedical recordsPurposePrevious workChi-square analysisBMICommon reasonAverage ageRisk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case–control study
Shen Y, Risch H, Lu L, Ma X, Irwin ML, Lim JK, Taddei T, Pawlish K, Stroup A, Brown R, Wang Z, Jia W, Wong L, Mayne ST, Yu H. Risk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case–control study. Cancer Causes & Control 2020, 31: 321-332. PMID: 32060838, PMCID: PMC7136513, DOI: 10.1007/s10552-020-01277-1.Peer-Reviewed Original ResearchConceptsRisk of HCCCase-control studyHepatocellular carcinomaRisk factorsHCV infectionHCC riskOdds ratioHepatitis C virus antibodyUnconditional logistic regression modelsElevated HCC riskRapid case ascertainmentC virus antibodyHeavy alcohol intakeConfidence intervalsFamily cancer historyImportant risk factorRandom digit dialingLow socioeconomic statusUnhealthy lifestyle choicesLower household incomeLogistic regression modelsNSAID useAlcohol intakeCigarette smokingHigher BMI
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2012
Obesity and endometrial cancer survival: a systematic review
Arem H, Irwin M. Obesity and endometrial cancer survival: a systematic review. International Journal Of Obesity 2012, 37: 634-639. PMID: 22710929, PMCID: PMC3774112, DOI: 10.1038/ijo.2012.94.Peer-Reviewed Original ResearchConceptsEndometrial cancer survivorsDisease-specific mortalityEndometrial cancerCancer survivorsGeneral populationObesity-related mortalityProgression-free survivalEndometrial cancer survivalBody mass indexPopulation of womenHigh mortality rateMagnitude of associationMultivariate adjustmentHealthy womenMass indexProspective studyCancer survivalInclusion criteriaMEDLINE searchMortality rateObesitySystematic reviewSignificant associationMortalityMeSH keywords
2011
A review of web‐based weight loss interventions in adults
Arem H, Irwin M. A review of web‐based weight loss interventions in adults. Obesity Reviews 2011, 12: e236-e243. PMID: 20804523, PMCID: PMC3086798, DOI: 10.1111/j.1467-789x.2010.00787.x.Peer-Reviewed Original ResearchConceptsWeight lossWeb-based weight loss interventionObesity-related health complicationsWeight loss interventionBurden of diseasePublic health practitionersInternet-delivered interventionsAssociated health consequencesLoss interventionLow adherenceHealthcare costsEfficacious interventionsHealth complicationsObesity ratesControl groupNon-Caucasian participantsHealth consequencesWeight gainHealth practitionersIntervention resultsDefinitive conclusionsPopulation-specific researchPeer-reviewed literatureInterventionMore males
2009
Exercise Improves Body Fat, Lean Mass, and Bone Mass in Breast Cancer Survivors
Irwin ML, Alvarez‐Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, Chung GG, Jones B, Knobf MT, DiPietro L. Exercise Improves Body Fat, Lean Mass, and Bone Mass in Breast Cancer Survivors. Obesity 2009, 17: 1534-1541. PMID: 19629060, PMCID: PMC2841468, DOI: 10.1038/oby.2009.18.Peer-Reviewed Original ResearchConceptsModerate-intensity aerobic exerciseUsual care participantsBreast cancer survivorsMin/weekDual-energy X-ray absorptiometryUsual care groupBone mineral densityCancer survivorsAerobic exerciseCare participantsLean massBody fatBody compositionCare groupBone massYale-New Haven Hospital Tumor RegistryPostmenopausal breast cancer survivorsCurrent physical activity levelsHospital tumor registryAerobic exercise interventionPhysical activity levelsBreast cancer prognosisPercent body fatX-ray absorptiometryBreast cancer diagnosis
2008
Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2008, 26: 3958-3964. PMID: 18711185, PMCID: PMC2654316, DOI: 10.1200/jco.2007.15.9822.Peer-Reviewed Original ResearchConceptsPhysical activityBreast cancerHazard ratioLifestyle StudyTotal deathsModerate-intensity physical activityMultivariable hazard ratiosPostdiagnosis physical activityProspective observational studyBreast cancer deathsBreast cancer survivorsMetabolic equivalent hoursRegional breast cancerPostdiagnosis changesPrimary outcomeCancer survivorsPrimary exposureCancer deathInactive womenObservational studyLower riskGreater riskDiagnosisInfluence of preWomen
2005
Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors
Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2881-2888. PMID: 16365005, PMCID: PMC3000615, DOI: 10.1158/1055-9965.epi-05-0185.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast cancer survivorsBody mass indexPhysical activityC-peptideMass indexCancer survivorsInactive breast cancer patientsLow IGF-I levelsIGF-binding protein-3Growth factorHigher C-peptideIIIA breast cancerIGF-I levelsRelationship of obesityLower C-peptideBreast cancer patientsInterview-administered questionnairePhysical activity categoriesBreast cancer prognosisPopulation-based sampleHormones/peptidesLeptin levelsHigher IGFCancer patientsChanges in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors
Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R. Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors. Journal Of Clinical Oncology 2005, 23: 774-782. PMID: 15681521, PMCID: PMC3000612, DOI: 10.1200/jco.2005.04.036.Peer-Reviewed Original ResearchConceptsBody fat changesBody fatBreast cancer diagnosisLifestyle factorsPhysical activityFat changesCancer diagnosisHigher disease stagePopulation-based studyBreast cancer recurrenceBreast cancer prognosisPercent body fatFirst yearLean womenObese womenBaseline visitPotential cofoundersDisease stageLifestyle StudyPostdiagnosis periodCancer recurrenceBreast cancerCancer prognosisFat lossYounger age
2004
Physical activity levels among breast cancer survivors.
Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Physical activity levels among breast cancer survivors. Medicine & Science In Sports & Exercise 2004, 36: 1484-91. PMID: 15354027, PMCID: PMC3000611.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsHispanic breast cancer survivorsLevel of PACancer survivorsPhysical activityWeight gainBlack breast cancer survivorsObese breast cancer survivorsSurveillance Epidemiology End ResultsPostdiagnosis weight gainNegative prognostic factorBreast cancer survivalRecreational physical activityPhysical activity levelsGeneral adult populationBreast cancer prognosisNon-Hispanic whitesCategories of adiposityPrognostic factorsType of sportDisease stageCancer survivalLifestyle StudyBreast cancerPA recommendations
2003
Physical activity levels before and after a diagnosis of breast carcinoma
Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard‐Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma. Cancer 2003, 97: 1746-1757. PMID: 12655532, PMCID: PMC3034406, DOI: 10.1002/cncr.11227.Peer-Reviewed Original ResearchConceptsBody mass indexPhysical activityBreast carcinomaIncident breast carcinomaPopulation-based studyRisk of recurrenceTotal physical activitySport physical activityPrediagnosis levelsAdjuvant treatmentPatient ageMass indexType of sportAdverse outcomesDisease stageTime patientsBaseline interviewBody weightPA levelsWeight gainPatientsDiagnosisCarcinomaWomenChemotherapy
2001
Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy
Irwin M, Ainsworth B, Conway J. Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy. Obesity 2001, 9: 517-525. PMID: 11557832, DOI: 10.1038/oby.2001.68.Peer-Reviewed Original ResearchConceptsBody fatPA recordsEnergy expenditureOverestimation of EESeven-Day Physical Activity RecallEstimation of EEMen 50 yearsBody mass indexHigher body fatnessPhysical activity levelsPhysical activity measuresPhysical activity recallYears of agePA assessment methodsEstimates of EEMass indexActivity recallBody fatnessBody weightOlder agePA levelsActivity measuresPA behaviorAdditional studiesPA measures