Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma
Fanok MH, Sun A, Fogli LK, Narendran V, Eckstein M, Kannan K, Dolgalev I, Lazaris C, Heguy A, Laird ME, Sundrud MS, Liu C, Kutok J, Lacruz RS, Latkowski JA, Aifantis I, Ødum N, Hymes KB, Goel S, Koralov SB. Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 2017, 138: 1116-1125. PMID: 29128259, PMCID: PMC5912980, DOI: 10.1016/j.jid.2017.10.028.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaHigh-throughput transcriptional profilingJAK/STATT cell receptor engagementT cellsGenetic perturbationsTranscriptome analysisTranscriptional profilingConditional geneDeep sequencingCytokine signalingTumor genomesMalignant T cellsCellular etiologyHeterogeneous landscapesReceptor engagementSmall animal modelsCommon variantsMycosis fungoidesKey cytokineAntigenic stimulationT lymphocytesLymphoma pathogenesisMouse model