2024
Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon
Yadem A, Armstrong J, Sarimollaoglu M, Kiki Massa C, Ndifo J, Menyaev Y, Mbe A, Richards K, Wade M, Zeng Y, Chen R, Zhou Q, Meten E, Ntone R, Tchuedji Y, Ullah S, Galanzha E, Eteki L, Gonsu H, Biris A, Suen J, Boum Y, Zharov V, Parikh S. Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon. Nature Communications 2024, 15: 9228. PMID: 39455558, PMCID: PMC11511992, DOI: 10.1038/s41467-024-53243-z.Peer-Reviewed Original ResearchConceptsClearance of parasitemiaDetection of malariaMalaria-infected red blood cellsDiagnosed symptomatic casesCross-sectional cohortUncomplicated malariaMalaria diagnosticsMalaria infectionRed blood cellsSymptomatic casesTarget antigenAsymptomatic reservoirCameroonian adultsFlow cytometer platformBlood samplesReservoir of infectionBlood cellsLack sensitivityLongitudinal cohortMolecular assaysMalariaIRBCPoint-of-careCohortQuantitative PCR
2019
Comparison on simultaneous capillary and venous parasite density and genotyping results from children and adults with uncomplicated malaria: a prospective observational study in Uganda
Lehane A, Were M, Wade M, Hamadu M, Cahill M, Kiconco S, Kajubi R, Aweeka F, Mwebaza N, Li F, Parikh S. Comparison on simultaneous capillary and venous parasite density and genotyping results from children and adults with uncomplicated malaria: a prospective observational study in Uganda. BMC Infectious Diseases 2019, 19: 559. PMID: 31242863, PMCID: PMC6595677, DOI: 10.1186/s12879-019-4174-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAIDS-Related Opportunistic InfectionsAnimalsAntimalarialsArtemether, Lumefantrine Drug CombinationCapillariesChildChild, PreschoolDrug MonitoringFemaleGenotypeGenotyping TechniquesHIVHIV InfectionsHumansInfantMalaria, FalciparumMaleMiddle AgedParasite LoadParasitemiaPlasmodium falciparumUgandaVeinsYoung AdultConceptsTime of presentationVenous blood smearsProspective observational studyParasite densityVenous compartmentBlood smearsVenous samplesObservational studyMSP-2Uncomplicated Plasmodium falciparum malariaTrial registrationThe trialPlasmodium falciparum malariaResultsTwo hundred twentyMalaria parasite densityClinical research settingResearch settingsUncomplicated malariaArtemether-lumefantrineFalciparum malariaParasite genotypingBland-Altman analysisHundred twentyMalaria diagnosisNew infectionsGold standard method