The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation
Ciovacco WA, Goldberg CG, Taylor AF, Lemieux JM, Horowitz MC, Donahue HJ, Kacena MA. The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. Bone 2008, 44: 80-86. PMID: 18848655, PMCID: PMC2659565, DOI: 10.1016/j.bone.2008.08.117.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsAnimals, NewbornCalciumCell CommunicationCell DifferentiationCell LineCell ProliferationConnexin 43Extracellular SpaceFemaleFlow CytometryGap JunctionsGene Expression RegulationGlycyrrhetinic AcidHumansMegakaryocytesMiceOleic AcidsOsteoblastsPregnancyReverse Transcriptase Polymerase Chain ReactionTritiumConceptsGJ intercellular communicationGene expressionIntercellular communicationGap junctionsOB proliferationMembrane-spanning channelsAbility of megakaryocytesPhosphatase enzymatic activityAlkaline phosphatase enzymatic activityOsteoblast proliferationBone cellsGJ proteinsPotential novel targetSignaling mechanismMatrix proteinsNodule formationEnzymatic activityEnzymatic levelsNovel targetMegakaryocytesDifferentiationOB culturesProteinConnexin 43Proliferation