2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
2012
Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery
Fields RJ, Cheng CJ, Quijano E, Weller C, Kristofik N, Duong N, Hoimes C, Egan ME, Saltzman WM. Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. Journal Of Controlled Release 2012, 164: 41-48. PMID: 23041278, PMCID: PMC3625648, DOI: 10.1016/j.jconrel.2012.09.020.Peer-Reviewed Original ResearchConceptsTransfection efficiencyPDNA loadingNovel nanoparticle systemPlasmid DNA loadingGene delivery vehiclesGene therapy applicationsPlasmid DNA deliverySurface coatingSurface chargePBAE polymerCoated nanoparticlesNanoparticle systemsLiposomal vectorsUnmodified particlesDNA deliveryDNA loadingPDNA deliveryTherapy applicationsCellular internalizationDelivery vehiclesUnmodified NPsPBAEIntracellular uptakeBlended particlesNanoparticles