2024
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedonia
2017
Posttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria
Spitzer EG, Zuromski KL, Davis MT, Witte TK, Weathers F. Posttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria. Suicide And Life-Threatening Behavior 2017, 48: 105-115. PMID: 28261858, DOI: 10.1111/sltb.12341.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorder (PTSD) symptom clustersPTSD symptom clustersSymptom clustersSpecific PTSD symptom clustersSix-factor Anhedonia modelTrauma-exposed undergraduatesInterpersonal-psychological theoryDSM-5 criteriaAcquired CapabilitySuppressor variableCommonality analysisAnhedonia modelBivariate correlationsSuicideComplex relationshipAnhedoniaFacetsUndergraduatesRelationshipStructure coefficientsFindingsTheory