Endothelins in inflammatory neurological diseases
D'Orléans-Juste P, Akide Ndunge O, Desbiens L, Tanowitz HB, Desruisseaux MS. Endothelins in inflammatory neurological diseases. Pharmacology & Therapeutics 2018, 194: 145-160. PMID: 30291906, PMCID: PMC6348026, DOI: 10.1016/j.pharmthera.2018.10.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous systemNeuroinflammatory processesCentral nervous system vasculitisNon-infectious inflammatory processesBlood-brain barrier levelEndothelin-1 antagonistsSynthesis of endothelinInflammatory neurological diseasesMediator/modulatorProgression of neurodegenerationPotent vasoactive compoundsNeuroinflammatory diseasesEndothelin pathwayEndothelin-1Inflammatory processClinical trialsVasoactive compoundsCardiovascular propertiesNervous systemAmino acid peptideNeurological diseasesEndothelial integrityEndothelinAlzheimer's diseaseNeurodegenerative disorders