Simulating complex patient populations with hierarchical learning effects to support methods development for post-market surveillance
Davis S, Ssemaganda H, Koola J, Mao J, Westerman D, Speroff T, Govindarajulu U, Ramsay C, Sedrakyan A, Ohno-Machado L, Resnic F, Matheny M. Simulating complex patient populations with hierarchical learning effects to support methods development for post-market surveillance. BMC Medical Research Methodology 2023, 23: 89. PMID: 37041457, PMCID: PMC10088292, DOI: 10.1186/s12874-023-01913-9.Peer-Reviewed Original ResearchConceptsSynthetic datasetsData characteristicsFeature distributionGround truthMIMIC-III dataReal-world dataData generation processComplex simulation studiesData relationshipsUser definitionSmall datasetsSimulation requirementsCorrelated featuresWorld dataCustomizable optionsReal-world complexitySynthetic patientsNew algorithmDatasetGeneration processLearningAlgorithmData simulation techniquesLearning effectGeneralizable framework