2023
The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial
Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Musinguzi N, Muzoora C, Bangsberg D, Davis J, Haberer J. The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial. PLOS Global Public Health 2023, 3: e0001813. PMID: 38051699, PMCID: PMC10697590, DOI: 10.1371/journal.pgph.0001813.Peer-Reviewed Original ResearchMedication adherenceControl armAcceptability dataTB medication adherenceTuberculosis medication adherenceDrug-sensitive tuberculosisDaily SMSMixed-methods pilotWeekly SMSElectronic adherence monitorsTB patientsMedian ageMonth 6Primary outcomeClinical outcomesMedian adherencePercent adherencePercentage adherenceSMS remindersStatus disclosureAdherence monitorsAdherence dataAdherence patternsRegistration numberMethods pilot
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosis
2019
Home-based tuberculosis contact investigation in Uganda: a household randomised trial
Davis JL, Turimumahoro P, Meyer AJ, Ayakaka I, Ochom E, Ggita J, Mark D, Babirye D, Okello DA, Mugabe F, Fair E, Vittinghoff E, Armstrong-Hough M, Dowdy D, Cattamanchi A, Haberer JE, Katamba A. Home-based tuberculosis contact investigation in Uganda: a household randomised trial. ERJ Open Research 2019, 5: 00112-2019. PMID: 31367636, PMCID: PMC6661318, DOI: 10.1183/23120541.00112-2019.Peer-Reviewed Original ResearchCommunity health workersTB contact investigationTuberculosis contact investigationContact investigationTB evaluationIndex patientsWorld Health OrganizationIntervention armHousehold tuberculosis contact investigationCare armHousehold contactsPulmonary TBSputum testingCare contactsHIV diagnosisSecondary outcomesHIV testingPrimary outcomeSymptomatic contactsHealth workersMicrobiologic testingHome evaluationIntervention componentsSputumPatients