Liangwen Zhong, PhD
Associate Research Scientist in Genetics
Research & Publications
Biography
Coauthors
Selected Publications
- Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation.Feng L, Barrows D, Zhong L, Mätlik K, Porter EG, Djomo AM, Yau I, Soshnev AA, Carroll TS, Wen D, Hatten ME, Garcia BA, Allis CD. Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation. BioRxiv 2023 PMID: 37808786, DOI: 10.1101/2023.09.29.560141.
- Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells.Zhong L, Gordillo M, Wang X, Qin Y, Huang Y, Soshnev A, Kumar R, Nanjangud G, James D, David Allis C, Evans T, Carey B, Wen D. Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells. Protein Cell 2023, 14: 591-602. PMID: 37029701, DOI: 10.1093/procel/pwad008.
- Self-patterning of human stem cells into post-implantation lineagesPedroza M, Gassaloglu S, Dias N, Zhong L, Hou T, Kretzmer H, Smith Z, Sozen B. Self-patterning of human stem cells into post-implantation lineages. Nature 2023, 622: 574-583. PMID: 37369348, PMCID: PMC10584676, DOI: 10.1038/s41586-023-06354-4.
- A Spatiotemporal Compartmentalization of Glucose Metabolism Guides Mammalian Gastrulation Progression.Cao D, Zhong L, Hemalatha A, Bergmann J, Cox AL, Greco V, Sozen B. A Spatiotemporal Compartmentalization of Glucose Metabolism Guides Mammalian Gastrulation Progression. BioRxiv 2023 PMID: 37333168, DOI: 10.1101/2023.06.06.543780.
- Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability.Guo P, Liu Y, Geng F, Daman AW, Liu X, Zhong L, Ravishankar A, Lis R, Barcia Durán JG, Itkin T, Tang F, Zhang T, Xiang J, Shido K, Ding BS, Wen D, Josefowicz SZ, Rafii S. Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature Cell Biology 2022, 24: 99-111. PMID: 34961794, PMCID: PMC9166935, DOI: 10.1038/s41556-021-00795-7.
- Exogenous insulin-like growth factor 1 accelerates growth and maturation of follicles in human cortical xenografts and increases ovarian output in mice.Man L, Lustgarten Guahmich N, Kallinos E, Park L, Caiazza B, Khan M, Liu ZY, Patel R, Torres C, Lekovich J, Zhong L, Bodine R, Wen D, Zaninovic N, Schattman G, Rosenwaks Z, James D. Exogenous insulin-like growth factor 1 accelerates growth and maturation of follicles in human cortical xenografts and increases ovarian output in mice. F S Sci 2021, 2: 237-247. PMID: 35560275, DOI: 10.1016/j.xfss.2021.07.002.
- Generation of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells.Qin Y, Wong B, Zhong L, Geng F, Parada LF, Wen D. Generation of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells. CRISPR J 2021, 4: 147-154. PMID: 33567216, DOI: 10.1089/crispr.2020.0074.
- A homozygous FANCM frameshift pathogenic variant causes male infertility.Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y, Shi Q. A homozygous FANCM frameshift pathogenic variant causes male infertility. Genet Med 2019, 21: 62-70. PMID: 29895858, DOI: 10.1038/s41436-018-0015-7.
- MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.Jiang H, Gao Q, Zheng W, Yin S, Wang L, Zhong L, Ali A, Khan T, Hao Q, Fang H, Sun X, Xu P, Pandita TK, Jiang X, Shi Q. MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice. PLoS Genet 2018, 14: e1007300. PMID: 29795555, DOI: 10.1371/journal.pgen.1007300.
- miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor.Chu B, Zhong L, Dou S, Wang J, Li J, Wang M, Shi Q, Mei Y, Wu M. miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor. J Mol Cell Biol 2015, 7: 12-22. PMID: 25635127, DOI: 10.1093/jmcb/mjv006.
- SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining.Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q. SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining. Nucleic Acids Res 2013, 41: D1055-62. PMID: 23193286, DOI: 10.1093/nar/gks1186.