2024
Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity
Matsumoto N, Barson D, Liang L, Crair M. Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity. Science 2024, 385: eadh7814. PMID: 39146415, DOI: 10.1126/science.adh7814.Peer-Reviewed Original ResearchConceptsSpontaneous activitySpontaneous retinal wavesAxonal connectionsPatterns of correlated activityNeonatal miceEvidence in vivoRetinal wavesPostsynaptic neuronsNeuronal activityIn vivoAxonal arborsAxonal processesAxonsRetinocollicular axonsNeural connectionsIndividual axonsMorphological changesSubcellular precisionEndogenous pattern
2022
Brainstem serotonin neurons selectively gate retinal information flow to thalamus
Reggiani J, Jiang Q, Barbini M, Lutas A, Liang L, Fernando J, Deng F, Wan J, Li Y, Chen C, Andermann M. Brainstem serotonin neurons selectively gate retinal information flow to thalamus. Neuron 2022, 111: 711-726.e11. PMID: 36584680, PMCID: PMC10131437, DOI: 10.1016/j.neuron.2022.12.006.Peer-Reviewed Original ResearchConceptsVisual information streamsRetinal ganglion cell typesBrainstem serotonin neuronsFiber photometry recordingsGanglion cell typesTwo-photon calcium imagingSerotonin neuronsVisual thalamusGlutamate releaseSerotonergic axonsRGC axonsSerotonin axonsThalamocortical neuronsAxon stimulationAwake micePresynaptic terminalsCalcium imagingOptogenetic stimulationCalcium activityLocal visual stimuliAxonsThalamusBoutonsVisual stimuliNeurons
2018
A Fine-Scale Functional Logic to Convergence from Retina to Thalamus
Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C, Andermann ML. A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell 2018, 173: 1343-1355.e24. PMID: 29856953, PMCID: PMC6003778, DOI: 10.1016/j.cell.2018.04.041.Peer-Reviewed Original ResearchConceptsAxonal boutonsRetinal ganglion cellsTwo-photon calciumImage-forming visionClusters of boutonsVisual thalamusGanglion cellsRetinal axonsBouton clustersThalamusMouse thalamusIndividual axonsDifferent axonsFeature selectivityBoutonsFine-scale organizationAxonsDendritic domainsUltrastructural analysisRetina