2024
Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice
Qi Q, Zhang H, Jin Z, Wang C, Xia M, Chen B, Lv B, Peres Diaz L, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L, Schneeberger M, Yu X. Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. Nature Metabolism 2024, 6: 1601-1615. PMID: 39030389, DOI: 10.1038/s42255-024-01068-x.Peer-Reviewed Original ResearchConceptsHost metabolismGLP-1 productionGut microbiotaUnfolded protein responseMicrobiota-derived metabolitesIntestinal L cellsInhibit mitochondrial respirationDiet-induced metabolic disordersGut hormone glucagon-like peptide 1Hormone glucagon-like peptide 1Intestinal symbiontsProtein responseGLP-1Male miceGLP-1 secretionMitochondrial respirationGene expressionL cellsGutGlucagon-like peptide 1Production of hydrogen sulfideMicrobiotaPathogenesis of metabolic syndromeGLP-1 levelsDesulfovibrio
2019
Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients
Riera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.Peer-Reviewed Original ResearchConceptsBlunt abdominal trauma patientsAbdominal trauma patientsFree fluidTrauma patientsUpper quadrantPredictive valueLevel I pediatric trauma centerPediatric trauma centerRetrospective chart reviewRight upper quadrantFAST examinationNegative predictive valuePositive predictive valueNegative likelihood ratioChart reviewBAT patientsMedian ageTrauma centerUpper abdomenIntraperitoneal fluidMAIN OUTCOMEPhysiologic amountsTrauma (FAST) examinationPatientsFocused assessment
2018
Reasons for parental withdrawal of care in a pediatric intensive care unit in China
Ho K, Wang X, Chen L. Reasons for parental withdrawal of care in a pediatric intensive care unit in China. PLOS ONE 2018, 13: e0199419. PMID: 30044777, PMCID: PMC6059386, DOI: 10.1371/journal.pone.0199419.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitClinical improvementCare unitDisease severityNon-withdrawal groupMean hospital chargesDay of deathICU stayHospital stayHospital chargesWithdrawal groupMedical costsMedical carePatientsCareSubstantial proportionAdmissionStaySubstantial numberSeverityLower disease severityFinancial hardshipLarge proportionDays
2017
“What do you know?”——knowledge among village doctors of lead poisoning in children in rural China
Huang R, Ning H, Baum CR, Chen L, Hsiao A. “What do you know?”——knowledge among village doctors of lead poisoning in children in rural China. BMC Public Health 2017, 17: 895. PMID: 29169343, PMCID: PMC5701361, DOI: 10.1186/s12889-017-4895-2.Peer-Reviewed Original ResearchConceptsVillage doctorsLead poisoningResultsA totalMultifaceted interventionsBackgroundThis studyPrevention strategiesCollege-level educationConclusionsThis studyLevel educationPoor knowledgeRural childrenPrevention measuresChildrenDoctorsQuestionnaire-based surveyPoisoningRural ChinaRural populationTest questionnaireClear needQuestionnaireAnnual incomeMethodsA
2016
Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED
Whitney RE, Santucci K, Hsiao A, Chen L. Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED. The American Journal Of Emergency Medicine 2016, 34: 1573-1575. PMID: 27289438, DOI: 10.1016/j.ajem.2016.05.075.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisPediatric emergency department (ED) visitsPOC testingEmergency department visitsLength of stayCost of admissionRandomized control trialChemistry testingCost-effective analysisDecision analysis modelCare testingDepartment visitsPediatric EDElectrolyte testingAdmission ratesSerum testingClinical assessmentControl trialMean savingsDegree of dehydrationPatientsCost savingsChildrenTrialsPayers
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosisUltrasound Evaluation of Skull Fractures in Children
Riera A, Chen L. Ultrasound Evaluation of Skull Fractures in Children. Pediatric Emergency Care 2012, 28: 420-425. PMID: 22531195, DOI: 10.1097/pec.0b013e318252da3b.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolDiagnosis, DifferentialFeasibility StudiesFemaleFollow-Up StudiesHumansInfantInfant, NewbornMalePilot ProjectsPoint-of-Care SystemsPredictive Value of TestsProspective StudiesROC CurveSkull FracturesTomography, X-Ray ComputedTrauma Severity IndicesUltrasonographyConceptsAcute closed head injuryClosed head injurySkull fractureBedside ultrasoundPediatric emergency medicineCT scanUrban tertiary care children's hospitalPredictive valueTertiary care children's hospitalTest characteristicsUnnecessary CT scansClinical decision rulePediatric emergency departmentEmergency medicineComputed tomography scanNegative predictive valuePositive predictive valueMonths of trainingMedian ageChildren's HospitalUltrasound evaluationEmergency departmentHead injuryBedside ultrasonographyTomography scan
2010
Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis
Chen L, Hsiao A, Langhan M, Riera A, Santucci KA. Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis. Academic Emergency Medicine 2010, 17: 1042-1047. PMID: 21040104, PMCID: PMC3058669, DOI: 10.1111/j.1553-2712.2010.00873.x.Peer-Reviewed Original ResearchMeSH KeywordsAortaChildChild, PreschoolCohort StudiesDehydrationDiarrheaEmergency Service, HospitalFemaleFluid TherapyGastroenteritisHemodynamicsHumansInfantInfusions, IntravenousLinear ModelsMaleObserver VariationPilot ProjectsPoint-of-Care SystemsProspective StudiesReproducibility of ResultsSeverity of Illness IndexUltrasonography, DopplerVena Cava, InferiorConceptsInferior vena cavaIVC/Ao ratioPediatric emergency departmentAo diametersAcute gastroenteritisAo ratioBedside ultrasound measurementAcute weight lossProspective observational studyResolution of symptomsAorta diameter ratioAcute care settingInterrater reliabilityPairs of investigatorsPearson correlation coefficientSignificant dehydrationGood interrater reliabilityEmergency departmentIntravascular volumeBedside USVena cavaBedside ultrasoundObservational studyCare settingsProspective identification
2007
Use of Ultrasound Measurement of the Inferior Vena Cava Diameter as an Objective Tool in the Assessment of Children with Clinical Dehydration
Chen L, Kim Y, Santucci KA. Use of Ultrasound Measurement of the Inferior Vena Cava Diameter as an Objective Tool in the Assessment of Children with Clinical Dehydration. Academic Emergency Medicine 2007, 14: 841-845. PMID: 17898246, DOI: 10.1197/j.aem.2007.06.040.Peer-Reviewed Original ResearchConceptsIVC/Ao ratioInferior vena cavaAo ratioInferior vena cava diameterUrban pediatric emergency departmentMean differenceUS measurementsProspective observational studyVena cava diameterPediatric emergency departmentWeight-matched controlsYears of ageIntravenous rehydrationClinical evidenceClinical dehydrationEmergency departmentVena cavaAssessment of childrenObservational studyDehydrated childrenUltrasonography measurementsUltrasound measurementsRank testObjective toolChildrenDiagnosis and Guided Reduction of Forearm Fractures in Children Using Bedside Ultrasound
Chen L, Kim Y, Moore CL. Diagnosis and Guided Reduction of Forearm Fractures in Children Using Bedside Ultrasound. Pediatric Emergency Care 2007, 23: 528-531. PMID: 17726410, DOI: 10.1097/pec.0b013e318128f85d.Peer-Reviewed Original ResearchConceptsPediatric emergency medicine physiciansForearm fracturesEmergency medicine physiciansBedside ultrasoundMedicine physiciansUltrasound-guided reductionUrban pediatric EDInitial success ratePediatric EDPostreduction radiographsRadiograph findingsCommon injuriesUltrasound findingsUltrasound guidanceForearm bonesUltrasound diagnosisPatientsStudy periodDiagnosisUltrasoundSuccess rateUltrasound unitFluoroscopy unitChildrenRadiographs
2006
Incidence and Predictors of Serious Bacterial Infections Among 57- to 180-Day-Old Infants
Hsiao AL, Chen L, Baker MD. Incidence and Predictors of Serious Bacterial Infections Among 57- to 180-Day-Old Infants. Pediatrics 2006, 117: 1695-1701. PMID: 16651326, DOI: 10.1542/peds.2005-1673.Peer-Reviewed Original ResearchConceptsSerious bacterial illnessWhite blood cell countDirect fluorescent antibodyBlood cell countPositive direct fluorescent antibodyCell countOlder infantsEtiology of feverHeight of feverOlder febrile infantsSerious bacterial infectionsRespiratory syncytial virusMonths of ageFebrile infantsPneumococcal diseaseBacterial meningitisVaccine eraRespiratory virusesProspective studySyncytial virusLumbar punctureUrine testsBacterial illnessNasal swabsFever
2005
Utility of Bedside Bladder Ultrasound Before Urethral Catheterization in Young Children
Chen L, Hsiao AL, Moore CL, Dziura JD, Santucci KA. Utility of Bedside Bladder Ultrasound Before Urethral Catheterization in Young Children. Pediatrics 2005, 115: 108-111. PMID: 15629989, DOI: 10.1542/peds.2004-0738.Peer-Reviewed Original ResearchConceptsPediatric emergency medicine physiciansAmount of urineUrethral catheterizationEmergency medicine physiciansBedside ultrasoundSufficient urineMedicine physiciansUrban pediatric emergency departmentIntervention phasePediatric emergency departmentPediatric emergency physiciansSuccess rateObservation phaseSimple noninvasive procedureSubsequent ultrasoundBladder ultrasoundFirst catheterizationUnsuccessful proceduresUrine cultureEmergency departmentIntervention periodInvasive testingEmergency physiciansCatheterizationUncomfortable procedure