2023
Provider Perceptions of Oxygenation Strategies for Critically Ill Trauma Patients With and Without Moderate-to-Severe Traumatic Brain Injury
Dylla L, Douin D, Cwik J, Steinwand A, Rice J, Jackson C, Anderson E, Higgins H, Monte A, Ginde A. Provider Perceptions of Oxygenation Strategies for Critically Ill Trauma Patients With and Without Moderate-to-Severe Traumatic Brain Injury. Military Medicine 2023, 188: 166-175. PMID: 37948260, PMCID: PMC11022338, DOI: 10.1093/milmed/usad076.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsCritical care providersTraumatic brain injuryCare providersTrauma patientsSupplemental oxygenNon-TBI patientsCross-sectional surveyUniversity of Colorado HospitalCase-based scenariosProviders' perceptionsProvider practicesCritically ill TBI patientsProviders' viewsOxygen useProvider typeAdministration of supplemental oxygenTargeted educationAssociated with increased mortalityBrain injuryOxygen saturation thresholdsModerate-to-severeSupplemental oxygen useFisher's exact testCritically ill patients
2021
A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial
Dylla L, Douin D, Anderson E, Rice J, Jackson C, Bebarta V, Lindsell C, Cheng A, Schauer S, Ginde A. A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. Trials 2021, 22: 784. PMID: 34749762, PMCID: PMC8574946, DOI: 10.1186/s13063-021-05688-6.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsImplementation trialStatistical analysis planMultimodal interventionTrauma patientsTraining periodStudy protocolTargeted normoxiaVentilator-free daysOne-month training periodGlasgow Outcome ScoreAnalysis planLevel 1 trauma centerCombat casualty careUsual carePre-implementationInjured trauma patientsSupplemental oxygenPost-implementationReduced logistical burdensIntervention phaseOutcome measuresCasualty careMulticenter clusterOutcome scoresA quasiexperimental study of targeted normoxia in critically ill trauma patients
Dylla L, Anderson E, Douin D, Jackson C, Rice J, Schauer S, Neumann R, Bebarta V, Wright F, Ginde A. A quasiexperimental study of targeted normoxia in critically ill trauma patients. Journal Of Trauma And Acute Care Surgery 2021, 91: s169-s175. PMID: 33797494, PMCID: PMC9709909, DOI: 10.1097/ta.0000000000003177.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsPostintervention subjectsPostintervention periodTrauma patientsTargeted normoxiaIntervention increased adherenceSupplemental oxygenChronic Health Evaluation II scoreEmergency department arrivalNeurosurgical intensive care unitMilitary trauma patientsIntensive care unitCOnsensus-basedQuasiexperimental studyPostinterventionLevels of FiO2Acute PhysiologyPatient timeII scoreClinical outcomesMm HgTherapeutic/care managementAvoidance of hypoxiaReduce morbidityPrimary outcome
2020
Retrospective analysis of the hemodynamic consequences of prehospital supplemental oxygen in acute stroke
Dylla L, Cushman J, Abar B, Benesch C, Jones C, O'Banion M, Adler D. Retrospective analysis of the hemodynamic consequences of prehospital supplemental oxygen in acute stroke. The American Journal Of Emergency Medicine 2020, 38: 2125-2129. PMID: 33069547, PMCID: PMC7704903, DOI: 10.1016/j.ajem.2020.07.021.Peer-Reviewed Original ResearchConceptsMean arterial pressureCerebral blood flowHemodynamic profileSupplemental oxygenRetrospective analysisHemodynamic consequencesOxygen saturationPrehospital oxygen saturationAcute strokePeripheral vascular resistanceLevels of supplemental oxygenAcademic comprehensive stroke centerSubjects' medical records.Comprehensive stroke centerClinical characteristicsAcute stroke patientsVascular resistanceArterial pressureMultivariate linear regressionMultivariate analysisImprove stroke outcomesMedical recordsGuidelines-Stroke registryPenumbral tissueBlood flow