Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Shvartsur A, Givechian KB, Garban H, Bonavida B. Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma. Journal Of Experimental & Clinical Cancer Research 2017, 36: 62. PMID: 28476134, PMCID: PMC5420138, DOI: 10.1186/s13046-017-0535-z.Peer-Reviewed Original ResearchConceptsRaf-1 kinase inhibitor proteinPatient-derived tumor tissueMultiple myelomaMM cell linesTumor tissueNovel therapeutic molecular targetsVariable clinical responseRKIP overexpressionNovel molecular therapeutic targetsNF-κB pathwayMolecular therapeutic targetsTherapeutic molecular targetsSignificant inverse correlationCell linesComplex heterogeneous diseaseMajority of cancersStage-specific biomarkersMEK/ERK1/2Raf/MEK/ERK1/2Clinical responseOverexpression of FasEffective therapeutic regimeDisease stageMetastatic tumorsPremalignant disease