Genetic Variation in the Mitochondrial Glycerol‐3‐Phosphate Acyltransferase Is Associated With Liver Injury
Hakim A, Moll M, Brancale J, Liu J, Lasky‐Su J, Silverman EK, Vilarinho S, Jiang ZG, Pita‐Juárez Y, Vlachos IS, Zhang X, Åberg F, Afdhal NH, Hobbs BD, Cho MH. Genetic Variation in the Mitochondrial Glycerol‐3‐Phosphate Acyltransferase Is Associated With Liver Injury. Hepatology 2021, 74: 3394-3408. PMID: 34216018, PMCID: PMC8639615, DOI: 10.1002/hep.32038.Peer-Reviewed Original ResearchMeSH KeywordsAcetyltransferasesChemical and Drug Induced Liver InjuryGenetic Association StudiesGenetic VariationGenome-Wide Association StudyHumansMitochondria, LiverConceptsAlcohol-associated liver diseaseChronic liver diseaseLiver diseaseLiver injuryAlanine aminotransferaseAspartate aminotransferaseElevated body mass indexLevels of ALTDose-dependent riskFatty liver diseaseBody mass indexAlkaline phosphataseMass General Brigham BiobankWeekly alcohol consumptionGenetic variantsMitochondrial glycerol-3-phosphate acyltransferaseLiver biochemistryHDL cholesterolLDL cholesterolTotal cholesterolMass indexRevision codesVLDL productionGlycerol-3-phosphate acyltransferaseTotal bilirubin