Featured Publications
Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment
Herrin J, Abraham NS, Yao X, Noseworthy PA, Inselman J, Shah ND, Ngufor C. Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment. JAMA Network Open 2021, 4: e2110703. PMID: 34019087, PMCID: PMC8140376, DOI: 10.1001/jamanetworkopen.2021.10703.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnticoagulantsAntifibrinolytic AgentsAtrial FibrillationClinical Decision-MakingCohort StudiesCross-Sectional StudiesFemaleFibrinolytic AgentsGastrointestinal HemorrhageHumansMachine LearningMaleMiddle AgedMyocardial IschemiaPredictive Value of TestsRetrospective StudiesRisk AssessmentThienopyridinesUnited StatesVenous ThromboembolismYoung AdultConceptsGastrointestinal bleedingIschemic heart diseaseCross-sectional studyThienopyridine antiplatelet agentAntithrombotic treatmentVenous thromboembolismAntiplatelet agentsRandom survival forestStudy cohortAtrial fibrillationValidation cohortHeart diseaseHAS-BLED risk scoreRetrospective cross-sectional studyCox proportional hazards regressionHAS-BLED scorePrior GI bleedPatients 18 yearsCohort of patientsEntire study cohortProportional hazards regressionOptumLabs Data WarehouseMedicare Advantage enrolleesPositive predictive valueRisk prediction model
2020
Risk of Systemic Adverse Events after Intravitreal Bevacizumab, Ranibizumab, and Aflibercept in Routine Clinical Practice
Maloney MH, Payne SR, Herrin J, Sangaralingham LR, Shah ND, Barkmeier AJ. Risk of Systemic Adverse Events after Intravitreal Bevacizumab, Ranibizumab, and Aflibercept in Routine Clinical Practice. Ophthalmology 2020, 128: 417-424. PMID: 32781110, DOI: 10.1016/j.ophtha.2020.07.062.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsBevacizumabCerebrovascular DisordersDrug-Related Side Effects and Adverse ReactionsFemaleHemorrhageHospitalizationHumansIntravitreal InjectionsMaleMyocardial InfarctionRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetinal DiseasesRetrospective StudiesRisk AssessmentVascular Endothelial Growth Factor AConceptsNeovascular age-related macular degenerationRetinal venous occlusive diseaseDiabetic retinal diseaseSystemic serious adverse eventsAnti-VEGF injectionsAnti-VEGF agentsMajor bleedingAcute myocardial infarctionCause hospitalizationCerebrovascular diseaseRoutine clinical practiceMyocardial infarctionIntravitreal bevacizumabTreatment initiationAdverse eventsPropensity score-weighted Cox proportional hazards modelClinical practiceLarge U.S. administrative claims databaseRisk of MICox proportional hazards modelU.S. administrative claims databaseAge-related macular degenerationRisk-adjusted effectSystemic safety profileRetrospective cohort study
2019
Risk of Readmission After Discharge From Skilled Nursing Facilities Following Heart Failure Hospitalization: A Retrospective Cohort Study
Weerahandi H, Li L, Bao H, Herrin J, Dharmarajan K, Ross JS, Kim KL, Jones S, Horwitz LI. Risk of Readmission After Discharge From Skilled Nursing Facilities Following Heart Failure Hospitalization: A Retrospective Cohort Study. Journal Of The American Medical Directors Association 2019, 20: 432-437. PMID: 30954133, PMCID: PMC6486375, DOI: 10.1016/j.jamda.2019.01.135.Peer-Reviewed Original ResearchConceptsSkilled nursing facilitiesSNF dischargeRetrospective cohort studySNF lengthHeart failureHF hospitalizationComposite outcomeCohort studyNursing facilitiesService beneficiaries 65Heart failure hospitalizationRisk of readmissionHazard rate ratiosFailure hospitalizationUnplanned readmissionHF diagnosisHospital dischargePostdischarge outcomesSNF stayMedicare patientsMedicare feeHome transitionPatientsReadmissionDay 3
2018
Seasonal Variation in Readmission Risk for Patients Hospitalized with Cardiopulmonary Conditions
Blecker S, Kwon JY, Herrin J, Grady JN, Horwitz LI. Seasonal Variation in Readmission Risk for Patients Hospitalized with Cardiopulmonary Conditions. Journal Of General Internal Medicine 2018, 33: 599-601. PMID: 29464475, PMCID: PMC5910346, DOI: 10.1007/s11606-017-4299-0.Peer-Reviewed Original Research
2017
Impact of a Shared Decision Making Intervention on Health Care Utilization: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial
Schaffer JT, Hess EP, Hollander JE, Kline JA, Torres CA, Diercks DB, Jones R, Owen KP, Meisel ZF, Demers M, Leblanc A, Inselman J, Herrin J, Montori VM, Shah ND. Impact of a Shared Decision Making Intervention on Health Care Utilization: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial. Academic Emergency Medicine 2017, 25: 293-300. PMID: 29218817, DOI: 10.1111/acem.13355.Peer-Reviewed Original ResearchConceptsHealth care utilizationLength of stayCare utilizationObservation unit admissionUnit admissionChest painED visitsIntervention armStudy armsIndex emergency department visitLow-risk chest painOverall health care utilizationSecondary analysisBilling dataIndex ED visitAcute coronary syndromeEmergency department visitsCardiac imaging testsCardiac stress testingPlanned secondary analysisHealth care systemInitial EDPragmatic multicenterCardiac testingCoronary syndrome
2016
Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial
Hess EP, Hollander JE, Schaffer JT, Kline JA, Torres CA, Diercks DB, Jones R, Owen KP, Meisel ZF, Demers M, Leblanc A, Shah ND, Inselman J, Herrin J, Castaneda-Guarderas A, Montori VM. Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial. The BMJ 2016, 355: i6165. PMID: 27919865, PMCID: PMC5152707, DOI: 10.1136/bmj.i6165.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAftercareAmbulatory CareAttitude of Health PersonnelChest PainChoice BehaviorConflict, PsychologicalDecision MakingDecision Support TechniquesEmergency Service, HospitalFemaleHealth Knowledge, Attitudes, PracticeHospital UnitsHospitalizationHumansMaleMiddle AgedMyocardial InfarctionObservationPatient Acceptance of Health CarePatient ParticipationPatient SatisfactionRisk AssessmentTrustConceptsAcute coronary syndromeMajor adverse cardiac eventsAdverse cardiac eventsCardiac testingCoronary syndromeChest painUsual careCardiac eventsPatient knowledgeLow-risk chest painPossible acute coronary syndromeDecision aid armFurther cardiac testingRandomized pragmatic trialRisk chest painUsual care armObservation unitProportion of patientsRate of admissionCare armSecondary outcomesPrimary outcomePrimary complaintTRIAL REGISTRATIONEmergency cliniciansDevelopment and validation of a simple risk score to predict 30‐day readmission after percutaneous coronary intervention in a cohort of medicare patients
Minges KE, Herrin J, Fiorilli PN, Curtis JP. Development and validation of a simple risk score to predict 30‐day readmission after percutaneous coronary intervention in a cohort of medicare patients. Catheterization And Cardiovascular Interventions 2016, 89: 955-963. PMID: 27515069, PMCID: PMC5397364, DOI: 10.1002/ccd.26701.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlgorithmsDecision Support TechniquesFemaleHumansLogistic ModelsMaleMedicareMultivariate AnalysisOdds RatioPatient ReadmissionPercutaneous Coronary InterventionPredictive Value of TestsRegistriesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsRisk of readmissionPCI patientsRisk scoreMultivariable logistic regression modelRisk score developmentDays of dischargeSimple risk scoreTime of dischargeModel c-statisticLogistic regression modelsStepwise selection modelCathPCI RegistryHospital dischargeReadmission ratesClinical factorsRevascularization proceduresValidation cohortC-statisticReadmissionHigh riskMedicare feeLower riskService claimsPatientsCohort
2015
Do Non-Clinical Factors Improve Prediction of Readmission Risk? Results From the Tele-HF Study
Krumholz HM, Chaudhry SI, Spertus JA, Mattera JA, Hodshon B, Herrin J. Do Non-Clinical Factors Improve Prediction of Readmission Risk? Results From the Tele-HF Study. JACC Heart Failure 2015, 4: 12-20. PMID: 26656140, PMCID: PMC5459404, DOI: 10.1016/j.jchf.2015.07.017.Peer-Reviewed Original ResearchConceptsReadmission ratesPatient-reported informationHeart failureHealth statusReadmission riskC-statisticRisk scorePsychosocial variablesMedical record abstractionWeeks of dischargeReadmission risk modelNon-clinical factorsCandidate risk factorsReadmission risk predictionRecord abstractionClinical variablesPatient interviewsMedical recordsRisk factorsPatientsPsychosocial informationPsychosocial characteristicsTelephone interviewsRisk predictionScores
2014
Effect of Age on Survival Between Open Repair and Surveillance for Small Abdominal Aortic Aneurysms
Filardo G, Lederle FA, Ballard DJ, Hamilton C, da Graca B, Herrin J, Sass DM, Johnson GR, Powell JT. Effect of Age on Survival Between Open Repair and Surveillance for Small Abdominal Aortic Aneurysms. The American Journal Of Cardiology 2014, 114: 1281-1286. PMID: 25159236, DOI: 10.1016/j.amjcard.2014.07.055.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmImmediate open repairAsymptomatic abdominal aortic aneurysmSmall abdominal aortic aneurysmsOpen repairAortic aneurysmEffect of ageFirst-line management strategyPooled patient-level dataNonclinical risk factorsUnited Kingdom Small Aneurysm TrialPatient-level dataLack of benefitSignificant differencesAneurysm TrialRisk factorsTreatment groupsPatientsAneurysmsLack of differenceTrialsSurvivalAgeWomenManagement trialsEffectiveness of the head CT choice decision aid in parents of children with minor head trauma: study protocol for a multicenter randomized trial
Hess EP, Wyatt KD, Kharbanda AB, Louie JP, Dayan PS, Tzimenatos L, Wootton-Gorges SL, Homme JL, RN L, LeBlanc A, Westphal JJ, Shepel K, Shah ND, Branda M, Herrin J, Montori VM, Kuppermann N. Effectiveness of the head CT choice decision aid in parents of children with minor head trauma: study protocol for a multicenter randomized trial. Trials 2014, 15: 253. PMID: 24965659, PMCID: PMC4081461, DOI: 10.1186/1745-6215-15-253.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDiverse emergency departmentsMinor head traumaCranial CT scanHead traumaEmergency departmentCT scanUsual careHealthcare utilizationParents of childrenImportant traumatic brain injuryMethods/designThisProportion of patientsBlunt head traumaHospital billing recordsPatient-centered outcomesClinical prediction ruleAvailable diagnostic optionsHead CT scanDecision aidElectronic medical recordsClinician surveyMulticenter trialMedical recordsRisk factorsEffectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial
Anderson RT, Montori VM, Shah ND, Ting HH, Pencille LJ, Demers M, Kline JA, Diercks DB, Hollander JE, Torres CA, Schaffer JT, Herrin J, Branda M, Leblanc A, Hess EP. Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial. Trials 2014, 15: 166. PMID: 24884807, PMCID: PMC4031497, DOI: 10.1186/1745-6215-15-166.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAngina, UnstableCardiology Service, HospitalClinical ProtocolsCommunicationConflict, PsychologicalDecision Support TechniquesEmergency Service, HospitalHealth Knowledge, Attitudes, PracticeHealth ResourcesHumansMyocardial InfarctionPatient Education as TopicPhysician-Patient RelationsPredictive Value of TestsPrognosisResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsUnited StatesVideo RecordingConceptsAdvanced cardiac testingAcute coronary syndromeDiverse emergency departmentsEmergency departmentCardiac testingHealthcare utilizationLow-risk chest pain patientsLow-risk chest painMajor adverse cardiac eventsMethods/designThisAdverse cardiac eventsLow-risk patientsProportion of patientsChest pain patientsCommon reason patientsEmergency department patientsPatient-clinician discussionsHospital billing recordsPatient-centered outcomesElectronic medical recordsAvailable management optionsDecision aidChest painCoronary syndromeUsual care
2012
Assessing the Impact of a Cooperative Group Trial on Breast Cancer Care in the Medicare Population
Soulos PR, Yu JB, Roberts KB, Raldow AC, Herrin J, Long JB, Gross CP. Assessing the Impact of a Cooperative Group Trial on Breast Cancer Care in the Medicare Population. Journal Of Clinical Oncology 2012, 30: 1601-1607. PMID: 22393088, PMCID: PMC3383112, DOI: 10.1200/jco.2011.39.4890.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBreast NeoplasmsCombined Modality TherapyDisease-Free SurvivalFemaleHumansLife ExpectancyMastectomy, SegmentalMedicareNeoplasm InvasivenessNeoplasm StagingPrognosisRadiotherapy, AdjuvantRisk AssessmentSEER ProgramSurvival AnalysisTreatment OutcomeUnited StatesConceptsUse of RTAdjuvant radiation therapyRadiation therapyOlder womenRT useLife expectancyBreast cancerMedicare populationEnd Results-Medicare dataStage I breast cancerStrata of ageCooperative group trialsI breast cancerBreast cancer careStrata of patientsHealth system characteristicsLog-binomial regressionShort life expectancySample of womenTreatment guidelinesCancer careInclusion criteriaGroup trialsMedicare beneficiariesClinical practice
2009
The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial
Carling CL, Kristoffersen DT, Flottorp S, Fretheim A, Oxman AD, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial. PLOS Medicine 2009, 6: e1000140. PMID: 19707579, PMCID: PMC2726763, DOI: 10.1371/journal.pmed.1000140.Peer-Reviewed Original ResearchConceptsSore throatVisual analog scaleBenefits of antibioticsVAS scoresRelative importance scoresDay threeDuration of symptomsTreatment effectsConsequence of treatmentProportion of peopleDetailed patient informationAntibiotic prescriptionsSymptom reliefRandomized trialsAnalog scaleAdult volunteersHealth programsSymptomsLogistic regressionAverage durationPatient informationMost participantsTrialsAntibioticsSignificant differences
2008
How Should the Impact of Different Presentations of Treatment Effects on Patient Choice Be Evaluated? A Pilot Randomized Trial
Carling C, Kristoffersen DT, Herrin J, Treweek S, Oxman AD, Schünemann H, Akl EA, Montori V. How Should the Impact of Different Presentations of Treatment Effects on Patient Choice Be Evaluated? A Pilot Randomized Trial. PLOS ONE 2008, 3: e3693. PMID: 19030110, PMCID: PMC2585274, DOI: 10.1371/journal.pone.0003693.Peer-Reviewed Original Research
2007
Quality Of Care For Acute Myocardial Infarction At Urban Safety-Net Hospitals
Ross JS, Cha SS, Epstein AJ, Wang Y, Bradley EH, Herrin J, Lichtman JH, Normand SL, Masoudi FA, Krumholz HM. Quality Of Care For Acute Myocardial Infarction At Urban Safety-Net Hospitals. Health Affairs 2007, 26: 238-248. PMID: 17211034, DOI: 10.1377/hlthaff.26.1.238.Peer-Reviewed Original ResearchAcute DiseaseAgedAged, 80 and overFemaleHealth Care SurveysHealth Services AccessibilityHospital MortalityHospitals, UrbanHumansMaleMedicareMyocardial InfarctionPatient AdmissionPatient TransferProspective Payment SystemQuality of Health CareReimbursement, Disproportionate ShareRetrospective StudiesRisk AssessmentUnited StatesVulnerable Populations
2006
Hospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality
Bradley EH, Herrin J, Elbel B, McNamara RL, Magid DJ, Nallamothu BK, Wang Y, Normand SL, Spertus JA, Krumholz HM. Hospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality. JAMA 2006, 296: 72-78. PMID: 16820549, DOI: 10.1001/jama.296.1.72.Peer-Reviewed Original ResearchMeSH KeywordsAgedCenters for Medicare and Medicaid Services, U.S.Cross-Sectional StudiesHospital MortalityHospitalsHumansJoint Commission on Accreditation of Healthcare OrganizationsMedicareMyocardial InfarctionOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesRisk AssessmentUnited StatesConceptsAcute myocardial infarctionMortality rateMyocardial infarctionProcess measuresAngiotensin-converting enzyme inhibitor useRisk-standardized mortality ratesShort-term mortality rateBeta-blocker useEnzyme inhibitor useHospital performanceHospital-level variationShort-term mortalityQuality process measuresAspirin useCessation counselingHospital outcomesInhibitor useAMI patientsNational registryMedication measuresTherapy measuresHospital qualityInfarctionMedicaid ServicesJoint CommissionEffect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortality
2002
The relation between methods and recommendations in clinical practice guidelines for hypertension and hyperlipidemia.
Fretheim A, Williams JW, Oxman AD, Herrin J. The relation between methods and recommendations in clinical practice guidelines for hypertension and hyperlipidemia. The Journal Of Family Practice 2002, 51: 963-8. PMID: 12485552.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedEvaluation Studies as TopicEvidence-Based MedicineFamily PracticeFemaleGuideline AdherenceHealth Planning GuidelinesHumansHyperlipidemiasHypertensionMaleMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Quality of Health CareRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexVirginiaConceptsClinical practice guidelinesPractice guidelinesDrug selectionTreatment thresholdSpecialty societiesInitial drug selectionCholesterol screeningGuideline developersSystematic reviewHypertensionHyperlipidemiaAggressive recommendationsGuidelinesWide variationGuideline methodsRecommendationsCriteria