2024
Is mild dehydration a risk for progression of childhood chronic kidney disease?
Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 39: 3177-3191. PMID: 38632124, PMCID: PMC11413076, DOI: 10.1007/s00467-024-06332-6.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease aetiologyKidney diseaseGraphical abstractA higher resolution versionMild dehydrationRisk of CKD progressionConcentrating capacityChronic kidney disease populationFrequency of dehydrationChildhood chronic kidney diseaseImpact renal functionRisk of complicationsLow fluid intakeAssessment of dehydrationChronic kidney disease outcomesHyperfiltration injuryRandomised controlled trialsArginine vasopressinRenal functionCKD progressionFluid intakeTreatment planningAdequate hydrationRisk factorsControlled trials
2023
Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease
Sandokji I, Xu Y, Denburg M, Furth S, Abraham A, Greenberg J. Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease. Nephron 2023, 148: 1-10. PMID: 37232009, PMCID: PMC10840447, DOI: 10.1159/000530918.Peer-Reviewed Original ResearchChronic kidney diseaseCKD progressionKidney diseaseNovel biomarkersProgression of CKDLong-term adverse outcomesPediatric chronic kidney diseaseKidney function declineGlomerular filtration rateRisk of deathScreening studyCKD pathophysiologyFunction declineKidney biomarkersAdverse outcomesProgression riskFiltration rateClinical managementEarly recognitionClinical trialsPrognostic markerEarly diagnosisHigh riskClinical practicePromising biomarkerAssociation of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adultsBiomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseChronic kidney diseaseEGFR declineCardiac surgeryHeart diseaseUrine uromodulinMedian eGFRIL-18Study visitGraphical abstractA higher resolution versionLong-term chronic kidney diseaseGlomerular filtration rate declineFaster eGFR declineIL-18 concentrationsLower median eGFRSurgical complexity scoreAcyanotic heart diseaseCongenital heart diseaseSubgroup of childrenTubular healthOverall cohortClinical factorsUrine biomarkersKidney diseaseUrinary biomarkers
2022
Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children
Politis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.Peer-Reviewed Original ResearchKidney injury biomarkersInjury biomarkersKidney biomarkersGamma-induced protein 10Glomerular filtration rateBirth cohort studyAlpha-1-microglobulinQuantile sum (WQS) regressionPrenatal metal exposureKidney injuryCohort studyUrinary CdPregnant womenSecond trimesterKidney diseasePrenatal exposureFiltration rateCystatin CUrinary metalsNull associationProtein 10A1MMetal exposureBiomarkersProtein 1