2021
Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports 2021, 34: 108777. PMID: 33657370, PMCID: PMC8009559, DOI: 10.1016/j.celrep.2021.108777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCRISPR-Cas SystemsDependovirusFemaleGene EditingGene Expression RegulationGenetic Association StudiesHEK293 CellsHumansInterleukinsMaleMAP Kinase Kinase KinasesMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionSTAT3 Transcription FactorConceptsOptic nerve crushRetinal ganglion cellsRegeneration-associated genesShort hairpin RNAIL-22Neural repairCentral nervous system traumaNeurological deficits persistNervous system traumaNerve crushAxonal damageAxonal regenerationGanglion cellsSystem traumaInflammatory responseCNS regenerationDeficits persistAxonal growthHairpin RNAConcurrent activationTranscription 3Cell-autonomous factorsKinase pathwaySignal transducerRepair
2019
Rorβ regulates selective axon-target innervation in the mammalian midbrain
Byun H, Lee HL, Liu H, Forrest D, Rudenko A, Kim IJ. Rorβ regulates selective axon-target innervation in the mammalian midbrain. Development 2019, 146: dev171926. PMID: 31332038, PMCID: PMC6679361, DOI: 10.1242/dev.171926.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral posterior nucleusLong-range neuronal connectionsSuperior colliculusNeuronal connectionsMammalian midbrainLateral geniculate nucleusThalamic nucleiAxonal projectionsGeniculate nucleusMidbrain centerPosterior nucleusMammalian brainInnervationRORβMidbrainDevelopmental mediatorTranscription factorsColliculusOpposite phenotypeNeuronsBrain
2017
Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury
Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WB. Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Reports 2017, 18: 2687-2701. PMID: 28297672, PMCID: PMC5389739, DOI: 10.1016/j.celrep.2017.02.058.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemFunctional recoveryIntact neuronsAdult mammalian central nervous systemPartial spinal cord injuryInjury-induced sproutingUnilateral brainstem lesionsGreater functional recoverySpontaneous functional recoveryCorticospinal motor neuronsCorticospinal tract axonsMammalian central nervous systemWild-type miceNew synapse formationGrowth modulatorsAdjacent injuryBrainstem lesionsCord injuryFunctional deficitsIntact circuitryCNS neuronsMotor neuronsCircuit plasticityNervous system
2015
Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling. Neuron 2015, 85: 1244-1256. PMID: 25754821, PMCID: PMC4391013, DOI: 10.1016/j.neuron.2015.02.017.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsDownregulation of PTENGanglion cellsInsulin-like growth factor-1Mouse retinal ganglion cellsAdministration of osteopontinAbility of RGCsSubtype-specific differencesGrowth factor-1Effect of osteopontinAxonal regenerationIGF-1High mTORSurvival rateΑRGCsMTOR pathwayPromising agentAxotomyMTOR signalingDistinct subsetsFactor 1Existence of subpopulationsInjuryOsteopontinDownregulation
2010
Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers
Kim IJ, Zhang Y, Meister M, Sanes JR. Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers. Journal Of Neuroscience 2010, 30: 1452-1462. PMID: 20107072, PMCID: PMC2822471, DOI: 10.1523/jneurosci.4779-09.2010.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsEarly postnatal stagesRGC subsetsSuperior colliculusSubset of RGCsRetinal ganglion cell dendritesPostnatal stagesGanglion cell dendritesInner plexiform layerLateral geniculate nucleusDevelopment of RGCsSpecific sublaminaeDistinct functional signaturesSubpial zoneGanglion cellsPlexiform layerCell dendritesAxonal projectionsDendritic arborsGeniculate nucleusSubtype-specific featuresAxonal arborsRetinorecipient layersMouse transgenic linesDiffuse pattern