Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation
Duan C, Li B, Liu H, Zhang Y, Yao X, Liu K, Wu X, Mao X, Wu H, Xu Z, Zhong Y, Hu Z, Gong Y, Xu H. Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation. Advanced Science 2024, e2408945. PMID: 39498889, DOI: 10.1002/advs.202408945.Peer-Reviewed Original ResearchCrystal-induced kidney injuryPGC-1aSingle-cell transcriptome sequencingNuclear factor erythroid 2-related factor 2Resistance to ferroptosisKidney injuryTranscriptional coactivatorTranscriptome sequencingRenal tubular epithelial cell injuryCalcium oxalate nephropathyPromoter regionRenal proximal tubular cellsTubular epithelial cell injuryEpithelial cell injuryProximal tubular cellsFactor erythroid 2-related factor 2Erythroid 2-related factor 2Oxalate nephropathyCell ferroptosisSIRT1Crystal nephropathyFerroptosisTubular cellsGPX4 transcriptionTherapeutic target